A5101565178- Immunotherapy and Immune Responses
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Aquaculture disease management and microbiota
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
- melanin and skin pigmentation
- Neonatal Respiratory Health Research
- Hypertrophic osteoarthropathy and related conditions
- Cellular transport and secretion
- Mosquito-borne diseases and control
- Systemic Sclerosis and Related Diseases
- Cytomegalovirus and herpesvirus research
- IL-33, ST2, and ILC Pathways
- Cancer-related cognitive impairment studies
- Collagen: Extraction and Characterization
- Telomeres, Telomerase, and Senescence
- Polyomavirus and related diseases
- Molecular Biology Techniques and Applications
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Genetics, Bioinformatics, and Biomedical Research
Gilead Sciences (United States)
2023-2024
Shandong First Medical University
2023
University of California, San Francisco
2016-2021
Purdue University West Lafayette
2008
Collagen-producing cells maintain the complex architecture of lung and drive pathologic scarring in pulmonary fibrosis. Here we perform single-cell RNA-sequencing to identify all collagen-producing normal fibrotic lungs. We characterize multiple subpopulations with distinct anatomical localizations different compartments murine One subpopulation, characterized by expression Cthrc1 (collagen triple helix repeat containing 1), emerges lungs expresses highest levels collagens. Single-cell human...
Fibrosis is a common pathological sequela of tissue injury or inflammation, and major cause organ failure. Subsets fibroblasts contribute to fibrosis in multiple ways, including generating contractile force activate integrin-bound, latent TGFβ secreting excess amounts collagens other extracellular matrix proteins (ECM) that make up pathologic scar. However, the precise fibroblast subsets drive have been poorly understood. In absence well-characterized markers, α-smooth muscle actin (αSMA)...
Transforming growth factor-β (TGFβ) is a key driver of fibrogenesis. Three TGFβ isoforms (TGFβ1, TGFβ2, and TGFβ3) in mammals have distinct functions embryonic development; however, the postnatal pathological roles activation mechanisms TGFβ2 TGFβ3 not been well characterized. Here, we show that latent forms can be activated by integrin-independent lower thresholds compared to TGFβ1. Unlike TGFB1, TGFB2 TGFB3 expression increased human lung liver fibrotic tissues healthy control tissues....
Progressive lung fibrosis is a major cause of mortality in systemic sclerosis (SSc) patients, but the underlying mechanisms remain unclear. We demonstrate that immune complexes (ICs) activate human monocytes to promote fibroblast migration partly via osteopontin (OPN) secretion, which amplified by autocrine monocyte colony stimulating factor (MCSF) and interleukin-6 (IL-6) activity. Bulk single-cell RNA sequencing elevated OPN expression SSc tissue enriched macrophages, partially overlapping...
Compromised regenerative capacity of lung epithelial cells can lead to cellular senescence, which may precipitate fibrosis. While increased markers senescence have been reported in idiopathic pulmonary fibrosis (IPF), the origin and identity these senescent remain unclear, tools characterize context-specific human are lacking. We observed that marker p16 is predominantly localized bronchiolized structures scarred regions IPF systemic sclerosis-associated interstitial disease (SSc-ILD)...
αvβ8 integrin, a key activator of transforming growth factor β (TGF-β), inhibits anti-tumor immunity. We show that potent blocking monoclonal antibody against (ADWA-11) causes suppression or complete regression in syngeneic models squamous cell carcinoma, mammary cancer, colon and prostate especially when combined with other immunomodulators radiotherapy. is expressed at the highest levels CD4+CD25+ T cells tumors, specific deletion β8 from as effective ADWA-11 suppressing tumor growth....
Golgi fragmentation is a common feature in multiple neurodegenerative diseases; however, the precise mechanism that causes remains obscure. A potential link between Cdk5 and Alzheimer's disease (AD) was investigated this study. Because physiologically fragmented during mitosis by Cdc2 kinase current Cdk5-specific chemical inhibitors target as well, development of novel tools to modulate activity essential. These enzyme modulators, created fusing TAT sequence activators an inhibitor peptide,...
Respiratory syncytial virus (RSV) is a significant cause of morbidity and mortality in high-risk populations. Although prophylactic options are available, there no effective oral therapeutics for RSV infection. Obeldesivir (ODV) an orally bioavailable prodrug the nucleoside analog GS-441524, which converted intracellularly to its active triphosphate inhibits RNA polymerase. Here we report potent antiviral activity ODV against geographically temporally diverse A B clinical isolates (EC 50 :...
Epilepsy, a group of chronic brain diseases characterized by different level dysfunction movement, sense, consciousness and autonomic nerve. The most common factors include: genetic factors, injury cell so on. At the molecular level, imbalance between inhibition excitation is considered as concrete mechanism. When ion channels on membrane change, flow ions will be interfered that excitability cells probably leading to epilepsy. Also, when production neurotransmitters goes wrong, normally...
The global demand for collagen is continuously growing over years. Nutritional regulation of quality and deposition in the swim bladder, an ideal source marine product, a promising method improving economic value fish. In this study, to enhance growth efficiency bladder important fish, chu's croaker (Nibea coibor), L9(34) orthogonal array was designed with three levels each factor, which are hydroxyproline (Hyp) key cofactors proline hydroxylation during post-translation modification, such...
MicroRNAs (miRNAs) are endogenous small non-coding RNAs that play important roles in several biological processes, including the regulation of body color. Leopard coral grouper ( Plectropomus leopardus ) is a valuable marine aquaculture fish; however, at present, there no published reports on its early color development. The skin P. undergoes transition from transparent to red 26 days post-hatching (dph) 30 dph. In this study, we performed miRNA sequencing dph (Transparent, PT) and (Red, PR)...
<h3>Background</h3> CD47 is a 'don't eat me' signal that frequently co-opted by tumors to evade phagocytosis tumor associated macrophages (TAM). Investigational agents targeting CD47, such as magrolimab, aim induce of cells. Single cell sequencing data analysis has identified C1QC-TAMs which express complement and pro-phagocytic genes, SPP1-TAMs pro-angiogenic markers. CRC patients with high C1QC low SPP1 scores were shown have longer OS/PFS.<sup>1</sup> Here, we validate the existing gene...
<h3>Background</h3> CD47 is a surface protein that protects cells from macrophage-mediated phagocytosis, and it highly expressed in many cancers. Anti-CD47 antibodies such as Magrolimab have the potential to promote phagocytosis of cancer cells. While expression colorectal cancers (CRC) generally moderate, was reported gene increases CRC liver metastases. However, sample numbers prior studies were limited not known whether treatment affects expression. Here we investigate chemotherapy...
Abstract The αvβ8 integrin is a key activator of transforming growth factor β (TGF β), which has been shown to inhibit anti-tumor immunity. Previous work suggested that on tumor cells could modulate and responses immune checkpoint blockade. We now show potent blocking monoclonal antibody against (ADWA-11) causes suppression or complete regression in syngeneic models squamous cell carcinoma (CCK168), mammary cancer (EMT-6), colon (CT26), prostate (TRAMPC2), especially when it combined with...
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Body colors are an important trait for the survival and reproduction of animals. In this study, transcriptomes related single nucleotide polymorphisms (SNPs) black- red-colored Plectropomus leopardus (Lacépède) were identified to investigate molecules SNP markers associated with body color formation. comparison red- black-colored groups, 489 differential expressed genes (DEGs) detected among them, 236 up- 253 down-regulated found in group. Gene ontology (GO) analysis DEGs showed that...
<h3>Background</h3> Immune checkpoint blockade targeting the PD-1/PD-L1 axis has revolutionized treatment of many solid tumors. PD-L1 expression is known to be modulated by both infiltrating T cells and tumor intrinsic mechanisms. Therapeutics macrophage checkpoints CD47 SIRPα are now being evaluated clinically, but little about how influenced molecular subtypes or presence immune cells, particularly macrophages. <h3>Methods</h3> Formalin fixed paraffin embedded samples primary, resectable...