A5066409584- Inflammatory Bowel Disease
- Microscopic Colitis
- Vitamin D Research Studies
- Eosinophilic Esophagitis
- Pregnancy and Medication Impact
- Gut microbiota and health
- Cancer Immunotherapy and Biomarkers
- Autoimmune and Inflammatory Disorders
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal motility and disorders
- Colorectal Cancer Treatments and Studies
- Reproductive System and Pregnancy
- Celiac Disease Research and Management
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Pharmacological Effects of Natural Compounds
- Clostridium difficile and Clostridium perfringens research
- Immune Cell Function and Interaction
- Gastrointestinal Bleeding Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- COVID-19 Clinical Research Studies
- Mycobacterium research and diagnosis
- CAR-T cell therapy research
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal disorders and treatments
Stanford University
2019-2025
Palo Alto University
2022-2024
Stanford Medicine
2019-2024
Chan Zuckerberg Initiative (United States)
2021-2023
Beth Israel Deaconess Medical Center
2016-2020
Harvard University
2016-2020
Baylor College of Medicine
2010
Abstract Background Vitamin D plays a protective role in ulcerative colitis (UC) patients through unclear mechanisms. Cathelicidin is an antimicrobial peptide induced by 1,25(OH)D2. Our goal was to evaluate the link between cathelicidin and vitamin D–associated clinical outcomes UC patients, explore induction of human colon cells, effects intrarectal on murine model colitis. Methods Serum colonic levels were measured correlated with histologic outcomes. Human cells treated 1,25(OH)2D...
Tumor necrosis factor (TNF) is a pleiotropic cytokine that plays critical role in the pathogenesis of immune-mediated diseases including inflammatory bowel disease (IBD). The stability its mRNA transcript, determined part by destabilizing sequences AAUU repeats (ARE) gene region, an important regulator tissue and systemic levels. A deletion ARE region resulted IBD arthritis mice pigs, supporting for human several arthritides. mutation same area mouse genome Genentech scientists (T.Y., M.K.)...
Abstract Background Patient and clinician interest in using diet inflammatory bowel disease (IBD) is strong, but high-quality data limited. Cycles of a short intermittent calorie restricted (IRCD) have been shown to improve metabolic outcomes healthy subjects, how this translates patients with IBD unclear. We conducted randomized control trial assess the effects IRCD on activity Crohn’s (CD). Methods analyzed from 97 mild moderate CD (Crohn’s Disease Activity Index, CDAI 151-450) between...
Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic tumor and associated with poor prognosis treatment response. The microenvironment (TME) recognized as an important factor in metastatic progression across cancers. Despite extensive study of TME PDAC, cellular molecular signaling networks remain poorly understood, largely due to tremendous heterogeneity tumors. While earlier work characterized PDAC immunologically privileged by immune system, recent studies revealed...
Abstract Inflammatory bowel disease (IBD), including both ulcerative colitis and Crohn's disease, is a chronic inflammatory of the gastrointestinal tract that thought to arise from combination environmental, genetic immunological factors. The gut microbiome, diverse ecosystem microorganisms residing in digestive tract, has been proposed play role pathogenesis IBD. There an unmet clinical need for microbiome‐based therapies. This review will discuss landscape therapeutics Microbiome‐targeted...