A5019723041- Medieval Literature and History
- Developmental Biology and Gene Regulation
- Sphingolipid Metabolism and Signaling
- Mycobacterium research and diagnosis
- Drug-Induced Adverse Reactions
- Polysaccharides and Plant Cell Walls
- Reproductive biology and impacts on aquatic species
- Atrial Fibrillation Management and Outcomes
- Communication in Education and Healthcare
- Proteoglycans and glycosaminoglycans research
- Inflammatory Bowel Disease
- Grief, Bereavement, and Mental Health
- Eurasian Exchange Networks
- Byzantine Studies and History
- Contact Dermatitis and Allergies
- Gastrointestinal motility and disorders
- Bone Tissue Engineering Materials
- Helicobacter pylori-related gastroenterology studies
- Historical Studies of British Isles
- Immune Response and Inflammation
- Food Allergy and Anaphylaxis Research
- Clostridium difficile and Clostridium perfringens research
- Blood Coagulation and Thrombosis Mechanisms
- Digestive system and related health
- Biliary and Gastrointestinal Fistulas
University of California, San Diego
2014-2025
National Tsing Hua University
2014-2024
University of Toronto
2022
Bridge University
2022
University of Virginia
2017-2021
Canberra Hospital
2013
ACT Government
2013
St. John's University
2004
The breakdown and release of hyaluronan (HA) from the extracellular matrix has been hypothesized to act as an endogenous signal injury. To test this hypothesis, we generated mice that conditionally overexpressed human hyaluronidase 1 (HYAL1). Mice expressing HYAL1 in skin either during early development or by inducible transient expression exhibited extensive HA degradation, yet displayed no evidence spontaneous inflammation. Further, activated migration promoted loss DCs skin. We...
Tumor necrosis factor (TNF) is a pleiotropic cytokine that plays critical role in the pathogenesis of immune-mediated diseases including inflammatory bowel disease (IBD). The stability its mRNA transcript, determined part by destabilizing sequences AAUU repeats (ARE) gene region, an important regulator tissue and systemic levels. A deletion ARE region resulted IBD arthritis mice pigs, supporting for human several arthritides. mutation same area mouse genome Genentech scientists (T.Y., M.K.)...
Abstract Background Sphingosine-1-phospate (S1P) receptor agonists (eg, ozanimod) desensitize migrating lymphocytes by irreversibly binding to S1P receptors (S1PR) and triggering their proteasomal degradation. Desensitized cannot sense S1P, therefore, halting lymphocyte recirculation. The lyase (SPL) degrades its inhibition disrupts the gradient. We previously found that systemic SPL inhibitors induce central immunosuppression. Here, we examined whether may attenuate colitis without...
ABSTRACT Thyroid hormone is a key regulator of post-embryonic vertebrate development. Skin biomedically important thyroid target organ, but the cellular and molecular mechanisms underlying skin pathologies associated with dysfunction remain obscure. The transparent zebrafish an accessible model system for studying During development zebrafish, scales emerge in from hexagonally patterned array dermal papillae, like other appendages such as feathers hair follicles. We show here that regulates...
Abstract This paper investigates thirteenth‐century perspectives on Mongol imperium from different parts of the world, by comparing Franciscan John Plano Carpini's *History Mongols* and anonymous *Secret History Mongols*, considered authoritative history empire an author close to imperial family. In thirteenth century, ascendency in East facilitated direct farreaching trade, communication, exchange between various world unparalleled before human history. While globalization did not exist...
INTRODUCTION: Probiotic use for management of GI conditions is becoming more popular, as it perceived to be a natural and low-risk therapeutic option. Despite their increasing use, how patients choose probiotics or providers make recommendations has not been well-studied. This survey aims characterize the pattern probiotic by providers. METHODS: Surveys were distributed seen at clinic single tertiary medical center. also who attended regional postgraduate course. Survey questions included...
In passus 15 of the C-text Piers Plowman , Will meets a doctor divinity at feast and is outraged by his simultaneous learning consumption. The mouths doctrinally “unobjectionable” definition Dowel, but accuses him being uncharitable to poor anyway (15.113–16, 76a). What conspicuously gives away emptiness religious discourse, us modern readers as well, enormous appetite this man for “manye sondry metes, mortrewes poddynges, / Brawen bloed gees, bacon colhoppes” (15.66–67).
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