A5078667532- Inflammatory Bowel Disease
- Microscopic Colitis
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Phagocytosis and Immune Regulation
- Pancreatic and Hepatic Oncology Research
- Clostridium difficile and Clostridium perfringens research
- Helicobacter pylori-related gastroenterology studies
- Diagnosis and treatment of tuberculosis
- Medical Imaging Techniques and Applications
- Dementia and Cognitive Impairment Research
- Autoimmune and Inflammatory Disorders
- Healthcare Policy and Management
- COVID-19 Clinical Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Primary Care and Health Outcomes
- Gastrointestinal motility and disorders
- Cardiac Arrest and Resuscitation
- Autoimmune and Inflammatory Disorders Research
- Functional Brain Connectivity Studies
- Liver Diseases and Immunity
- IL-33, ST2, and ILC Pathways
- Alzheimer's disease research and treatments
- Breast Cancer Treatment Studies
University of Colorado Denver
2021-2025
University of Colorado Anschutz Medical Campus
2021-2024
University of Michigan
2017-2021
Michigan Medicine
2017-2021
Paracelsus Medical University
2017
University of Cincinnati Medical Center
2016
Swedish University of Agricultural Sciences
2013
University of California, Los Angeles
2007-2009
Friedrich Schiller University Jena
2003-2006
UCLA Health
2006
INTRODUCTION: A significant proportion of patients with acute severe ulcerative colitis (ASUC) require colectomy. METHODS: Patients ASUC treated upadacitinib and intravenous corticosteroids at 5 hospitals are presented. The primary outcome was 90-day colectomy rate. Secondary outcomes included frequency steroid-free clinical remission, adverse events, all-cause readmissions. RESULTS: Of the 25 upadacitinib, 6 (24%) underwent colectomy, 15 (83%) 18 available data who did not undergo...
<i>Background:</i> Apathy is the most common noncognitive symptom inAlzheimer’s disease (AD). The structural correlates of apathy in AD have not yet been described. <i>Methods:</i> We analyzed magnetic resonance imaging data 35 patients with and without apathy. <i>Results:</i> There was a significant linear association between severity cortical gray matter atrophy bilateral anterior cingulate [Brodmann area (BA) 24; r = 0.39–0.42, p 0.01] left medial...
Background: Alzheimer disease (AD) is the most common form of dementia worldwide.Mild cognitive impairment (MCI) recent terminology for patients with deficiencies in absence functional decline.Most MCI harbor pathologic changes AD and demonstrate transition to at a rate 10% 15% per year.Patients experience progressive brain atrophy.Objective: To analyze structural magnetic resonance imaging data 24 amnestic 25 mild using an advanced 3-dimensional cortical mapping technique.Design:...
Fibrosis is the final common pathway to intestinal failure in Crohn's disease, but no medical therapies exist treat fibrosis. Activated myofibroblasts are key effector cells of fibrosis multiple organ systems, including intestine. AXL a receptor tyrosine kinase that has been implicated fibrogenic pathways involving myofibroblast activation. We aimed investigate as potential target for treatment fibrosis.To establish proof concept, we first analyzed gene expression 2 vivo models and 3 vitro...
Tumor necrosis factor (TNF) is a pleiotropic cytokine that plays critical role in the pathogenesis of immune-mediated diseases including inflammatory bowel disease (IBD). The stability its mRNA transcript, determined part by destabilizing sequences AAUU repeats (ARE) gene region, an important regulator tissue and systemic levels. A deletion ARE region resulted IBD arthritis mice pigs, supporting for human several arthritides. mutation same area mouse genome Genentech scientists (T.Y., M.K.)...
OBJECTIVE Many low-risk unruptured intracranial aneurysms (UIAs) are followed for growth with surveillance imaging. Growth of UIAs likely increases the risk rupture. The incidence and factors UIA or de novo aneurysm formation require further research. authors retrospectively identify annual in an protocol. METHODS Over 11.5-year period, recommended imaging to 192 patients 234 UIAs. was assessed. With logistic regression, patient compliance protocol RESULTS During 621 patient-years follow-up,...
Neutrophils (polymorphonuclear leukocytes, PMNs) comprise a major component of the immune cell infiltrate during acute mucosal inflammation and have an important role in molding inflammatory tissue environment. While PMNs are essential to clearance invading microbes, PMN antimicrobial enzyme myeloperoxidase (MPO) can also promote bystander damage. We hypothesized that blocking MPO would attenuate colitis prevent development chronic by limiting Using dextran sodium sulfate model murine...
Epidemiological studies have shown that ingestion of isoflavone-rich soy products is associated with a reduced risk for the development breast cancer. In present study, we investigated hypothesis genistein modulates expression glutathione S -transferases (GSTs) in human cells, thus conferring protection towards genotoxic carcinogens which are GST substrates. Our approach was to use mammary cell lines MCF-10A and MCF-7 as models non-neoplastic neoplastic epithelial respectively. cells...
The aim of this study was to investigate the longitudinal positron emission tomography (PET) metabolic changes in elderly. Nineteen nondemented subjects (mean Mini-Mental Status Examination 29.4 ± 0.7 SD) underwent two detailed neuropsychological evaluations and resting 2-deoxy-2-[F-18]fluoro-d-glucose (FDG)-PET scan (interval 21.7 3.7 months), baseline structural 3T magnetic resonance (MR) imaging, apolipoprotein E4 genotyping. Cortical PET were analyzed 3-D using cortical pattern matching...
Intestinal fibrosis and subsequent intestinal obstruction are common complications of Crohn's disease (CD). Current therapeutics combat inflammation, but no pharmacological therapy exists for fibrostenotic disease. Pathological persistence activated myofibroblasts is a key driver in CD. In other organ systems, BH-3 mimetic drugs that affect Bcl-2 apoptotic pathways induce apoptosis reduce fibrogenic gene expression, thereby reducing fibrosis.
High-deductible health plans (HDHPs) are increasing in prevalence as a cost control device for slowing care growth by reducing nonessential medical service utilization. High cost-sharing associated with HDHPs can lead to significant financial distress and worse disease outcomes. We hypothesize that chronic patients delaying or foregoing necessary due costs.A retrospective cohort analysis of IBD at risk high utilization continuous enrollment either an HDHP THP from 2009 2016 were identified...
Abstract Background Clostridioides difficile infection (CDI) is a leading cause of health care–associated and may result in organ dysfunction, colectomy, death. Published risk scores to predict severe complications from CDI demonstrate poor performance upon external validation. We hypothesized that building validating model using geographically temporally distinct cohorts would more accurately for CDI. Methods conducted multicenter retrospective cohort study adults diagnosed with After...
Abstract Neutrophil (PMN) infiltration during active inflammation imprints changes in the local tissue environment. Such responses are often accompanied by significant extracellular acidosis that result predictable transcriptional responses. In this study, we explore mechanisms involved inflammatory acidification as a of PMN–intestinal epithelial cell (IEC) interactions. Using recently developed tools, revealed PMN transepithelial migration (TEM)-associated is dependent on total number PMNs...