A5008977974- Inflammatory Bowel Disease
- Pregnancy and Medication Impact
- Eosinophilic Esophagitis
- Microscopic Colitis
- Obesity and Health Practices
- Reproductive System and Pregnancy
- Diet and metabolism studies
- Colorectal Cancer Screening and Detection
- Single-cell and spatial transcriptomics
- Bariatric Surgery and Outcomes
- Colorectal Cancer Surgical Treatments
- Vitamin C and Antioxidants Research
- Healthcare cost, quality, practices
- Diverticular Disease and Complications
- Pharmaceutical studies and practices
- Cardiovascular Issues in Pregnancy
- Pregnancy and preeclampsia studies
- Adolescent and Pediatric Healthcare
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 and healthcare impacts
- Birth, Development, and Health
- Hidradenitis Suppurativa and Treatments
- Dietary Effects on Health
- Pharmacology and Obesity Treatment
- Pain Management and Opioid Use
Stanford University
1997-2025
Stanford Medicine
2022
Palo Alto University
2021
Kaiser Permanente Vallejo Medical Center
2007
Colorado State University
2001
Abstract Inflammatory bowel disease (IBD) includes Crohn’s and ulcerative colitis. Each is characterized by a diverse set of potential manifestations, which determine patients’ phenotype. Current understanding phenotype determinants limited, despite increasing prevalence healthcare costs. Diagnosis monitoring requires invasive procedures, such as endoscopy tissue biopsy. Here we report signatures heterogeneity between diagnoses phenotypes. Using mass cytometry, analyze leukocyte subsets,...
Although literature suggests that resistance to TNF inhibitor (TNFi) therapy in patients with ulcerative colitis (UC) is partially linked immune cell populations the inflamed region, there still substantial uncertainty underlying relevant spatial context. Here, we used highly multiplexed immunofluorescence imaging technology CODEX create a publicly browsable tissue atlas of inflammation 42 regions from 29 UC and 5 healthy individuals. We analyzed 52 biomarkers on 1,710,973 spatially resolved...
Abstract Background Patient and clinician interest in using diet inflammatory bowel disease (IBD) is strong, but high-quality data limited. Cycles of a short intermittent calorie restricted (IRCD) have been shown to improve metabolic outcomes healthy subjects, how this translates patients with IBD unclear. We conducted randomized control trial assess the effects IRCD on activity Crohn’s (CD). Methods analyzed from 97 mild moderate CD (Crohn’s Disease Activity Index, CDAI 151-450) between...
Despite incredible growth in systems of care and rapidly expanding therapeutic options for people with inflammatory bowel disease, there are significant barriers that prevent patients from benefiting these advances. These include restrictions the form prior authorization, step therapy, prescription drug coverage. Furthermore, inadequate use multidisciplinary disease specialists limits patient access to high-quality care, particularly medically vulnerable populations. However, opportunities...
Objective Given the increasing evidence that obesity increases risk of developing and dying from malignancy, American Society Clinical Oncology (ASCO) launched an Obesity Initiative in 2013 was designed to increase awareness among oncology providers general public relationship between cancer promote research this area. Recognizing type societal change required impact epidemic will require a broad‐based effort, ASCO hosted “Summit on Addressing through Multidisciplinary Collaboration” 2016....
Inflammatory bowel disease (IBD) reproductive health counseling is associated with higher knowledge, lower voluntary childlessness, greater medication adherence during pregnancy, and improved outcomes of pregnancy. Our aims were to assess knowledge about IBD in a tertiary care patient population.We anonymously surveyed women men ages 18 45 cared for at the Stanford clinic administered CCPKnow questionnaire. STATA was used summarize descriptive statistics compare categorical variables using...
Readmission within 30 days occurs in up to 18% of admitted patients with ulcerative colitis (UC). The importance postdischarge follow-up a gastroenterologist as well the optimal interval is unknown.
Lay Summary We report an association between balsalazide exposure during the development of fertilizing sperm and birth defects in offspring. Exposed offspring were approximately 8 times more likely to have a defect. There no pre-existing reasons suspect such relationship, which should be confirmed other data.
IBD and reproductive health counseling (IBD-RHC) is associated with higher knowledge, lower voluntary childlessness greater medication adherence during pregnancy. Yet prior studies show documentation of IBD-RHC low in both women men, few patients are satisfied advice received on family planning 1. Quantify rates IBD-RHC. 2. Investigate factors 3. Assess knowledge interest further education health. We anonymously surveyed men ages 18-45 over a 6-month period 2018 regarding their histories...
Abstract Ulcerative colitis is a chronic-relapsing inflammatory disease of the large intestine with complex, multifactorial pathogenesis. TNF inhibitors are widely used to suppress immune-mediated tissue damage in ulcerative patients; however, therapy failures common. Predicting inhibitor response requires an understanding architectural features that underlie mucosal inflammation and those responsible for resistance. Here, we highly multiplexed immunofluorescence uncover spatially resolved...