A5049142333- Microscopic Colitis
- Inflammatory Bowel Disease
- Eosinophilic Esophagitis
- Pregnancy and Medication Impact
- Clostridium difficile and Clostridium perfringens research
- Coenzyme Q10 studies and effects
- Immunodeficiency and Autoimmune Disorders
- Helicobacter pylori-related gastroenterology studies
- Mitochondrial Function and Pathology
- Health Systems, Economic Evaluations, Quality of Life
- Vitamin C and Antioxidants Research
- Diverticular Disease and Complications
- Pharmaceutical studies and practices
- Cytomegalovirus and herpesvirus research
- Adolescent and Pediatric Healthcare
- Reproductive System and Pregnancy
- Hidradenitis Suppurativa and Treatments
- Parasites and Host Interactions
- Mycobacterium research and diagnosis
- Acne and Rosacea Treatments and Effects
- Gastrointestinal disorders and treatments
- Acute Lymphoblastic Leukemia research
- Pharmacological Effects of Natural Compounds
- Biochemical Acid Research Studies
- Cancer Research and Treatments
Stanford University
2018-2025
Harvard University
2015-2016
Massachusetts General Hospital
2016
New York Proton Center
2015
Engineering Associates (United States)
2015
Iowa City Public Library
2015
University of Wisconsin–Madison
2012-2014
One-fifth of patients with Crohn's disease (CD) are primary non-responders to anti-tumor necrosis factor (anti-TNF) therapy, and an estimated 10-15% will fail therapy annually. Little is known about the genetics response anti-TNF therapy. The aim our study was identify genetic factors associated non-response (PNR) loss anti-TNFs in CD.From a prospective registry, we characterized 427 CD their first Patients were designated as achieving response, durable non-durable based on clinical,...
BACKGROUND Clostridium difficile infection (CDI) is the most common healthcare-associated and associated with considerable morbidity. Recurrent CDI a key contributing factor to this Despite an estimated 83,000 recurrences annually in United States, there are few accurate estimates of costs recurrent CDI. OBJECTIVE We performed study (1) identify health consequences including need for repeat hospitalization, intensive care unit (ICU) stay, surgery; (2) determine determinants such costs; (3)...
ABSTRACT Esophageal Crohn's disease is uncommon and difficult to identify, especially in the adult population. In this study, we report a biologic-naïve patient with colonic complicated by recurrent esophageal strictures despite many dilations, who presented our center aspiration pneumonia. He was found have tracheoesophageal fistula as likely etiology. After multidisciplinary discussion, he underwent esophagectomy given severity of his stenosis. The patient's surgical course dysphonia due...
Intestinal infections are common in patients with inflammatory bowel disease (IBD) and may mimic IBD flares. In this study, we estimate the changing incidence of intestinal among hospitalizations assess impact on key hospitalization metrics.The National Inpatient Sample (NIS) was analyzed for from between 1998 2014. were identified using ICD-9-CM codes, each infection calculated Crohn's (CD) ulcerative colitis (UC). Linear logistic regression analyses used to effects duration, charges,...
OBJECTIVE To develop an algorithm using administrative codes, laboratory data, and medication data to identify recurrent Clostridium difficile infection (CDI) examine the sensitivity, specificity, positive negative predictive values, performance of this algorithm. METHODS We identified all patients with 2 or more International Classification Diseases, Ninth Edition, Clinical Modification (ICD-9-CM) codes for CDI (008.45) from January 1 through December 31, 2013. Information on number...
Readmission within 30 days occurs in up to 18% of admitted patients with ulcerative colitis (UC). The importance postdischarge follow-up a gastroenterologist as well the optimal interval is unknown.
Inflammatory bowel disease (IBD) presents unique challenges for young adult men that extend beyond physical symptoms, encompassing psychosocial dimensions affecting all aspects of life. This article draws insights from a roundtable discussion facilitated by the Crohn's and Colitis Young Adults Network (CCYAN), focusing on experiences living with IBD. It sheds light intersections IBD men's sexual reproductive health, fertility, mental well-being while identifying gaps in care. The offers...
age, and since that period it had grown steadily
We report a 73-year-old woman from Dominica with anorexia and weight loss who was found to have strongyloides infection on esophagogastroduodenoscopy subsequently treated 40 μg/kg of ivermectin for 2 days, although most experts recommend 200 μg/kg. An incidental stage 1 endometrial carcinoma found, hysterectomy performed postoperative dexamethasone nausea. Her vomiting worsened, she re-presented the hospital anasarca, severe hyponatremia, oral intolerance. The syndrome inappropriate...
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The UbiB family of kinases represents an estimated 25% the protein kinase‐like (PKL) members in microbial kingdom, and this are required for biosynthesis coenzyme Q from E. coli to humans. We present first structure a member, human mitochondrial kinase ADCK3, which is mutated cerebellar ataxia (ARCA2) associated with deficiency. ADCK3 reveals that signature, invariant KxGQ motif interacts directly active site, close proximity residues important nucleotide binding. Differential scanning...
Defects in Coenzyme Q (Q) biosynthesis cause human disease and may have a significant impact on aging. Particularly, patients with mutations an atypical mitochondrial kinase develop deficiency progressive cerebellar ataxia. However, the mechanisms by which this affects ataxia are unknown. Identifying endogenous substrates of would represent key advance our understanding its function. Toward end, we performed multiple vitro experiments. Radiolabeling mouse lysates 32 P‐ATP revealed lipid...