A5059310727- Clostridium difficile and Clostridium perfringens research
- Microscopic Colitis
- Nosocomial Infections in ICU
- Gut microbiota and health
- Viral gastroenteritis research and epidemiology
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Infection Control in Healthcare
- Healthcare cost, quality, practices
- Antimicrobial Resistance in Staphylococcus
- Neutropenia and Cancer Infections
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Urinary Tract Infections Management
- Mycobacterium research and diagnosis
- Cytomegalovirus and herpesvirus research
- Botulinum Toxin and Related Neurological Disorders
- Antifungal resistance and susceptibility
- Hematopoietic Stem Cell Transplantation
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Streptococcal Infections and Treatments
- Fungal Infections and Studies
- Antibiotic Resistance in Bacteria
- Infection Control and Ventilation
Washington University in St. Louis
2016-2025
Oregon Medical Research Center
2022-2024
Lindsay Unified School District
2022-2024
New York Proton Center
2007-2024
Communities In Schools of Orange County
2022-2024
University of Pittsburgh
2024
Office of Infectious Diseases
2004-2023
Jewish Hospital
2012-2023
European Society of Clinical Microbiology and Infectious Diseases
2023
Manhattan Institute for Policy Research
2023
A panel of experts was convened by the Infectious Diseases Society America (IDSA) and for Healthcare Epidemiology (SHEA) to update 2010 clinical practice guideline on Clostridium difficile infection (CDI) in adults. The update, which has incorporated recommendations children (following adult epidemiology, diagnosis, treatment), includes significant changes management this reflects evolving controversy over best methods diagnosis. remains most important cause healthcare-associated diarrhea...
Abstract A panel of experts was convened by the Infectious Diseases Society America (IDSA) and for Healthcare Epidemiology (SHEA) to update 2010 clinical practice guideline on Clostridium difficile infection (CDI) in adults. The update, which has incorporated recommendations children (following adult epidemiology, diagnosis, treatment), includes significant changes management this reflects evolving controversy over best methods diagnosis. remains most important cause healthcare-associated...
Background. The epidemiology of Clostridium difficile -associated disease (CDAD) is changing, with evidence increased incidence and severity. However, the understanding magnitude reasons for this change currently hampered by lack standardized surveillance methods. Objective Methods. An ad hoc C. working group was formed to develop interim definitions recommendations based on existing literature expert opinion that can help improve CDAD prevention efforts. Definitions Recommendations. A case...
Previously published guidelines are available that provide comprehensive recommendations for detecting and preventing healthcare-associated infections. The intent of this document is to highlight practical in a concise format designed assist acute care hospitals implement prioritize their surgical site infection (SSI) prevention efforts. Refer the Society Healthcare Epidemiology America/Infectious Diseases America “Compendium Strategies Prevent Healthcare-Associated Infections” Executive...
Previously published guidelines are available that provide comprehensive recommendations for detecting and preventing healthcare-associated infections. The intent of this document is to highlight practical in a concise format designed assist acute care hospitals implementing prioritizing their central line–associated bloodstream infection (CLABSI) prevention efforts. Refer the Society Healthcare Epidemiology America/Infectious Diseases America “Compendium Strategies Prevent...
Infectious diseases are important causes of morbidity and mortality in patients with cancer. The NCCN Clinical Practice Guidelines Oncology (NCCN Guidelines) for Prevention Treatment Cancer-Related Infections characterize the major pathogens to which cancer susceptible, a focus on prevention, diagnosis, treatment common opportunistic infections. This portion guidelines highlights sections antifungal antiviral prophylaxis. Antifungal prophylaxis recommendations have expanded over past few...
Previously published guidelines are available that provide comprehensive recommendations for detecting and preventing healthcare-associated infections. The intent of this document is to highlight practical in a concise format designed assist acute care hospitals implementing prioritizing their catheter-associated urinary tract infection (CAUTI) prevention efforts. Refer the Society Healthcare Epidemiology America/Infectious Diseases America “Compendium Strategies Prevent...
Patients with cancer are at increased risk for developing infectious complications during the course of their disease and treatment. The following sections NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) Prevention Treatment Cancer-Related Infections provide an overview factors complications, recommendations categorization, strategies prevention infections high-risk patient populations cancer. Individualized evaluation incorporation preventative measures essential components...
Previously published guidelines are available that provide comprehensive recommendations for detecting and preventing healthcare-associated infections. The intent of this document is to highlight practical in a concise format designed assist acute care hospitals implementing prioritizing their ventilator-associated pneumonia (VAP) prevention efforts. Refer the Society Healthcare Epidemiology America/Infectious Diseases America “Compendium Strategies Prevent Healthcare-Associated Infections”...
Preventable healthcare-associated infections (HAIs) occur in US hospitals. Preventing these is a national priority, with initiatives led by healthcare organizations, professional associations, government and accrediting agencies, legislators, regulators, payers, consumer advocacy groups. To assist acute care hospitals focusing prioritizing efforts to implement evidence-based practices for prevention of HAIs, the Society Healthcare Epidemiology America Infectious Diseases Standards Practice...
An abstract is not available for this content so a preview has been provided. Please use the Get access link above information on how to content.
Bezlotoxumab is a human monoclonal antibody against Clostridium difficile toxin B indicated to prevent C. infection (CDI) recurrence (rCDI) in adults at high risk for rCDI. This post hoc analysis of pooled monocolonal antibodies C.difficile therapy (MODIFY) I/II data assessed bezlotoxumab efficacy participants with characteristics associated increased The population was the modified intent-to-treat who received or placebo (n = 1554) by factors rCDI that were prespecified statistical plan:...
Antibiotics are deployed against bacterial pathogens, but their targeting of conserved microbial processes means they also collaterally perturb the commensal microbiome. To understand acute and persistent effects antibiotics on gut microbiota healthy adult volunteers, we quantify microbiome dynamics before, during, 6 months after exposure to 4 commonly used antibiotic regimens. We observe an decrease in species richness culturable bacteria antibiotics, with most microbiomes returning...
Microbiota-based treatments reduce the incidence of recurrent Clostridioides difficile infections (rCDIs), but prospectively collected safety data needed to broaden patient access and protect public health have been limited.We provide cumulative from five prospective clinical trials evaluating fecal microbiota, live-jslm (RBL) - first microbiota-based live biotherapeutic product approved by US Food Drug Administration for preventing rCDI in adults.Integrated analysis includes three phase II...
Previous studies of risk factors for Clostridium difficile-associated disease (CDAD) have been limited by small sample sizes and case-control study designs. Many these were performed during outbreaks CDAD. Colonization pressure use fluoroquinolones, vancomycin, gastric acid suppressors not fully evaluated as The purpose this was to determine endemic CDAD, including CDAD pressure, a modified version colonization pressure.We retrospective cohort 36,086 patients admitted Barnes-Jewish Hospital...
Clinical characteristics, risks, and outcomes in solid organ transplant (SOT) recipients with zygomycosis the era of modern immunosuppressive newer antifungal agent use have not been defined.In a matched case-controlled study, SOT were prospectively studied. The primary outcome measure was success (complete or partial response) at 90 days.Renal failure (odds ratio [OR], 3.17; P = .010), diabetes mellitus (OR, 8.11; < .001), prior voriconazole and/or caspofungin 4.41; .033) associated higher...
Previously published guidelines are available that provide comprehensive recommendations for detecting and preventing healthcare-associated infections. The intent of this document is to highlight practical in a concise format designed assist acute care hospitals implementing prioritizing their Clostridium difficile infection (CDI) prevention efforts. Refer the Society Healthcare Epidemiology America/Infectious Diseases America “Compendium Strategies Prevent Healthcare-Associated Infections”...
ABSTRACT Asymptomatic Clostridium difficile colonization is common in hospitalized patients. Existing C. assay comparisons lack data on severity of diarrhea or patient outcomes, limiting the ability to interpret their results regard diagnosis infection (CDI). The objective this study was measure how including presentation with result impacted performance diagnose CDI. Stool specimens from 150 patients that met inclusion and exclusion criteria were selected. Nine methods detect stool...
The incidence of Clostridium difficile-associated disease (CDAD) is increasing. There are few data on the short-term and long-term attributable costs CDAD. objective this study was to determine acute 180-day inpatient CDAD.We performed a retrospective cohort all patients without operating room who were admitted for > or =48 h Barnes-Jewish Hospital, tertiary care hospital in St. Louis, Missouri, 1 January 2003-31 December 2003 (n = 24,691). Attributable CDAD determined by multivariable...
Previously published guidelines are available that provide comprehensive recommendations for detecting and preventing healthcare-associated infections (HAIs). Our intent in this document is to highlight practical a concise format assist acute care hospitals their efforts prevent transmission of methicillin-resistant Staphylococcus aureus (MRSA). Refer the Society Healthcare Epidemiology America/Infectious Diseases America “Compendium Strategies Prevent Healthcare-Associated Infections”...
Background. Managing recurrent Clostridium difficile infection (CDI) presents a significant challenge for clinicians and patients. Fecal microbiota transplantation (FMT) is highly effective therapy CDI, yet availability of standardized, safe, product has been lacking. Our aim in this study was to assess the safety effectiveness RBX2660 (microbiota suspension), commercially prepared FMT drug manufactured using standardized processes available ready-to-use format. Methods. Patients with at...
Abstract We conducted a retrospective cohort study to compare Clostridium difficile–associated disease rates determined by C. difficile–toxin assays and International Classification of Diseases, 9th Revision (ICD-9) codes. The correlation between toxin assay results ICD-9 codes was good (κ = 0.72, p<0.01). sensitivity the 78% specificity 99.7%.