A5103029670- Antibiotic Resistance in Bacteria
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Cytomegalovirus and herpesvirus research
- Infectious Diseases and Mycology
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Polyomavirus and related diseases
- Actinomycetales infections and treatment
- Mycobacterium research and diagnosis
- Transplantation: Methods and Outcomes
- Respiratory viral infections research
- Pneumocystis jirovecii pneumonia detection and treatment
- School Health and Nursing Education
- Antibiotic Use and Resistance
- Asthma and respiratory diseases
- Antimicrobial Resistance in Staphylococcus
- Herpesvirus Infections and Treatments
- Urinary Tract Infections Management
- Pediatric health and respiratory diseases
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Primary Care and Health Outcomes
- Renal Transplantation Outcomes and Treatments
- Parvovirus B19 Infection Studies
Loyola University Chicago
2013-2024
Loyola University Medical Center
2013-2024
University of Washington
2024
University of Illinois Chicago
1987-2012
University of Michigan
2000-2012
Office of Infectious Diseases
2001-2010
Hôpital Xavier Arnozan
2008
University of Nebraska–Lincoln
2006
Michigan Medicine
2001
Michigan Department of Health and Human Services
1985-1999
Clinical characteristics, risks, and outcomes in solid organ transplant (SOT) recipients with zygomycosis the era of modern immunosuppressive newer antifungal agent use have not been defined.In a matched case-controlled study, SOT were prospectively studied. The primary outcome measure was success (complete or partial response) at 90 days.Renal failure (odds ratio [OR], 3.17; P = .010), diabetes mellitus (OR, 8.11; < .001), prior voriconazole and/or caspofungin 4.41; .033) associated higher...
Baseline data obtained from a study of 276 children with asthma 259 low income families were analyzed to test the hypothesis that passive smoking is associated frequency emergency room (ER) visits, hospitalizations, and impaired pulmonary function. The using multiple regression techniques. We controlled for other variables might affect ER including by themselves presence irritants or allergens in child's home. Passive was positively visits (p less than 0.01), but not hospitalizations...
Caregiving tasks reported by family members are summarized based on empirical, review, and service program reports, a categorization of these is presented. Reports education support programs for fmaily caregivers also analyzed. Current evaluation data point only to benefits in short-term, affective domains caregiving. Needed areas demonstration study determine how can yield more long-term include skills development, stages caregiving, characteristics persons likely benefit, empirically-based...
Abstract These updated guidelines from the Infectious Diseases Community of Practice American Society Transplantation review diagnosis, prevention, and management Nocardia infections after solid organ transplantation (SOT). have increased in last two decades, likely due to improved detection identification methods an expanding immunocompromised population. The risk developing nocardiosis varies with type transplanted immunosuppression regimen used. infection most commonly involves lung....
S.A. Grim, L. Proia, R. Miller, M. Alhyraba, A. Costas‐Chavarri, J. Oberholzer, N.M. Clark. A multicenter study of histoplasmosis and blastomycosis after solid organ transplantation. Transpl Infect Dis 2011. All rights reserved Aim. review the clinical presentation, diagnosis, treatment outcomes 30 transplant recipients (SOTRs) with or from 3 Midwestern academic medical centers. Background. The endemic fungal pathogens, Histoplasma capsulatum Blastomyces dermatitidis , may cause severe...
A 53-year-old woman experienced a multidrug-resistant (MDR) Acinetobacter baumannii urinary tract infection 5 months after undergoing kidney and liver transplantation. The tigecycline minimum inhibitory concentration (MIC) for her A. isolate was 1.5 microg/ml; the patient received 2 weeks of therapy with intravenous as 100-mg loading dose followed by 50 mg every 12 hours, no lapses in treatment resolution infection. Three later, MDR isolated from sputum setting clinical evidence pneumonia,...
We sought to determine the impact of timing appropriate antifungal therapy, as assessed by susceptibility results, on patient survival. Patients ≥16 years age with first episodes candidaemia during 2001–09 were included. Clinical data collected retrospectively, including time therapy and The study population included 446 patients [243 (54%) female, mean 53 years] candidaemia, 380 (85%) whom had data. Candida albicans was most common pathogen (221, 50%) followed glabrata (99, 22%),...
Abstract Bacteria within the genus Acinetobacter (principally A. baumannii-calcoaceticus complex [ABC]) are gram-negative coccobacilli that may cause nosocomial infections in critically ill or debilitated patients (particularly ventilator-associated pneumonia and of bloodstream, urinary tract, wounds). Treatment is difficult, as spp. intrinsically resistant to multiple antimicrobial agents, have a remarkable ability acquire new resistance determinants via mechanisms include plasmids,...
The optimal treatment for respiratory syncytial virus (RSV) infection in adult immunocompromised patients is unknown. We assessed the management of RSV and other non-influenza viruses Midwestern transplant centers.A survey assessing strategies viral infections was sent to 13 centers.Multiplex polymerase chain reaction assay used diagnosis 11/12 centers. Eight 12 centers inhaled ribavirin (RBV) some patient populations. Barriers included cost, safety, lack evidence, inconvenience. Six...
Few options are available for cytomegalovirus (CMV) treatment in transplant recipients resistant, refractory, or intolerant to approved agents. Letermovir (LET) is prophylaxis hematopoietic cell (HCT) recipients, but little known about efficacy CMV infection. We conducted an observational study determine the patterns of use and outcome LET infection recipients.Patients who received were identified at 13 centers. Demographic data collected.Twenty-seven solid organ 21 HCT (one dual) from...
OBJECTIVES: This study investigated the relationship between psychosocial and behavioral factors frequency of emergency department visits for childhood asthma. METHODS: Data obtained from a survey parents 445 children who were being treated asthma in room large urban hospital examined. RESULTS: Factors associated with high use included child's younger age, greater number days symptoms asthma, higher medicines prescribed, prior hospitalization lower level parental confidence efficacy...
Journal Article Impact of Self-Management Education on the Functional Health Status Older Adults with Heart Disease Get access N. M. Clark, PhD, PhD 2Department Behavior and Education, School Public Health, University MichiganAnn Arbor, Ml 48109-2029 Search for other works by this author on: Oxford Academic PubMed Google Scholar K. Janz, H. Becker, A. Schork, 3Department Biostatistics, Michigan J. Wheeler, 4Department Services Management Policy, Liang, Dodge, MS, MS S. Keteyian, 5Levine...
Abstract: Immunosuppressive protocols for ABO‐incompatible (ABOI) and positive cross‐match (PCM) solid organ transplant (SOT) recipients have included the use of rituximab (RTX). Infectious complications (IC) been reported after RTX other indications, but not well studied in SOT population. We performed a retrospective review IC occurring within six months ABOI PCM renal transplantation (RT) receiving RTX. Medical records were reviewed bloodstream, lung, gastrointestinal tract, allograft, or...
Fifty-eight solid organ transplant recipients with zygomycosis were studied to assess the presentation, radiographic characteristics, risks for extra-pulmonary dissemination and mortality of pulmonary zygomycosis. Pulmonary was documented in 31 patients (53%) developed a median 5.5 months (interquartile range, 2-11 months) posttransplantation. In all, 74.2% (23/31) had limited lungs 25.8% (8/31) lung disease as part disseminated zygomycosis; cutaneous/soft tissue (50%, 4/8) most common site...