A5001069596- Head and Neck Cancer Studies
- Telomeres, Telomerase, and Senescence
- Medical Imaging Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- Oral health in cancer treatment
- MicroRNA in disease regulation
- Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Metastasis and carcinoma case studies
- Trace Elements in Health
- Natural product bioactivities and synthesis
- Peptidase Inhibition and Analysis
- Colorectal and Anal Carcinomas
- Virus-based gene therapy research
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Research and Treatments
- Radiation Therapy and Dosimetry
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- HER2/EGFR in Cancer Research
- Prostate Cancer Treatment and Research
- Salivary Gland Disorders and Functions
- Nanoplatforms for cancer theranostics
Zhongnan Hospital of Wuhan University
2015-2025
Wuhan University
2015-2025
China-Japan Friendship Hospital
2024-2025
Shanghai Institute of Materia Medica
2024
University of Chinese Academy of Sciences
2024
Shanghai Institute of Hematology
2022
The First Affiliated Hospital, Sun Yat-sen University
2022
Zhongshan Hospital
2022
Fudan University
2022
Sun Yat-sen University
2022
We have previously demonstrated that clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) acts as a zinc ionophore and induces apoptosis of human cancer cells; however, the mechanisms clioquinol/zinc-induced apoptotic cell death remain to be elucidated further. Using fluorescence-labelled probes, present study has examined intracellular distribution after treatment in cells order identify cellular targets for ionophores. DU 145, prostate line, was chosen model system study, results were confirmed...
We have reported that Chinese herbs Astragalus polysaccharide (APS) can inhibit nuclear factor kappaB (NF-κB) activity during the development of diabetic nephropathy in mice. NF-κB plays important roles genesis, growth, and metastasis cancer. is also involved treatment resistance tumors. Here we investigated antitumor APS human non-small cell lung cells (A549 NCI-H358) related mechanisms action.The dose-effect time-effect were determined cancer line A549 NCI-H358. The inhibition effect on...
The functions of the high mobility group box 1 (HMGB1) in tumor cells include replenishing telomeric DNA and maintaining cell immortality. There is a negative correlation between human telomerase reverse transcriptase (hTERT) radiosensitivity cells. Our aim was to elucidate relationship among HMGB1, telomere homeostasis MCF-7 In this study, we established stably transfected control (MCF-7-NC) HMGB1 knockdown (MCF-7-shHMGB1) lines. expression mRNA relative length were examined by real-time...
Abstract Molecular glue degraders (MGDs) represent a promising strategy for targeted protein degradation within cells. While chemoproteomics has unveiled hundreds of potential MGD targets, very few proteins are degraded by highly selective and potent MGDs. Here, we developed novel glutarimide analog with tetrahydroimidazo[1,2‐ ]pyrazine scaffold that exhibited strong NIMA‐related kinase 7 (NEK7) potential. Further optimization led to the identification LC‐04‐045 as leading NEK7 candidate,...
Molecular glue degraders (MGDs) represent a promising strategy for targeted protein degradation within cells. While chemoproteomics has unveiled hundreds of potential MGD targets, very few proteins are degraded by highly selective and potent MGDs. Here, we developed novel glutarimide analog with tetrahydroimidazo[1,2‐a]pyrazine scaffold that exhibited strong NIMA‐related kinase 7 (NEK7) potential. Further optimization led to the identification LC‐04‐045 as leading NEK7 candidate,...
Antibody-drug conjugates (ADCs) are a transformative approach in breast cancer therapy, offering targeted treatment with reduced toxicity by selectively delivering cytotoxic agents to cells. While ADCs like trastuzumab emtansine (T-DM1), deruxtecan (T-DXd), and sacituzumab govitecan have shown significant efficacy, resistance mechanisms such as antigen loss, impaired internalization, efflux of payloads challenge their effectiveness. This review discusses these explores advanced strategies...
Background Identifying the risk of psoriasis relapse after discontinuing biologics can help optimize treatment strategies, potentially reducing rates and alleviating burden disease management.
A 60-year-old male patient underwent a PET/CT scan at our hospital one month ago, which revealed lesion in the right kidney. Four years he had radical surgery for thyroid cancer and neck lymph node dissection another hospital, with postoperative pathology confirming papillary carcinoma. Physical examination no palpable masses bilateral renal regions, tenderness or percussion pain was detected. Laboratory tests indicated mild anemia slight function abnormalities. CT showed round isodense...
Background Diabetic Kidney Disease (DKD) is a serious complication of diabetes, imposing substantial medical burden. The significance N6-methyladenosine (m6A) modification in the pathogenesis DKD has become increasingly prominent. Aim This study aimed to investigate specific expression patterns m6A geneset DKD. Method Bulk RNA, single-cell and spatial transcriptome were utilized clarify hub gene. 3 types machine learning algorithms applied. possible compounds screened based on DSigDB...
Objective: To explore the risk factors of cervical lymph node metastasis in oral squamous cell carcinoma (OSCC) patients with clinical negative nodes(cN0) and provide a reference for treatment.Methods: The data 161 OSCC cN0 were retrospectively analyzed.All underwent extended primary resection combined dissection.The level number confirmed by postoperative pathology.The analyzed univariate multivariate Logistic regression analysis.Results: Thirty-one out cases (19%) metastasis.Among them,...
Abstract The human telomerase reverse transcriptase (hTERT) is highly expressed in a variety of tumors. transforming growth factor beta receptor type II (TGFBR2) downstream protein (TGF-β) which suppresses activity. However, the relevance survival to expression TGFBR2, hTERT or TGFBR2/hTERT has not been previously investigated cervical cancer tissues. Our study showed that patients with low level TGFBR2 were associated poor prognosis (HR = 1.704, P 0.021), but no significant between and...
Background: Radiotherapy is an indispensable part of the multidisciplinary treatment breast cancer (BC). Due to potential for serious side effects from ionizing radiation in cancer, which can adversely affect patient’s quality life, dose often limited. This limitation result incomplete eradication tumors. Methods: In this study, biomimetic copper single-atom catalysts (platelet cell membrane camouflaging, PC) were synthesized with aim improving therapeutic outcomes radiotherapy BC. Following...
The known functions of telomerase in tumor cells include replenishing telomeric DNA and maintaining cell immortality. We have previously shown the existence a negative correlation between human reverse transcriptase (hTERT) radiosensitivity cells. Here we set out to elucidate molecular mechanisms underlying regulation by MCF-7 Toward this aim, yeast two-hybrid (Y2H) screening laryngeal squamous carcinoma radioresistant (Hep2R) cDNA library was first performed search for potential hTERT...
Abstract Background Gene therapy is a promising therapeutic approach for cancer. Targeted expression of desired proteins within the tumor best to reduce toxicity and improve survival. This study establish more effective less toxic gene Methods Combined strategy with recombinant adenovirus expressing horseradish peroxidase (HRP) mediated by human telomerase reverse transcriptase (hTERT) promoter (AdhTERTHRP) murine interleukin-12 (mIL-12) under control Cytomegalovirus (CMV) (AdCMVmIL-12) was...
BackgroundRadiotherapy is one of the major therapeutic strategies in cancer treatment. The telomere-binding protein TPP1 an important component shelterin complex at mammalian telomeres. Our previous reports showed that expression was elevated radioresistant cells, but exact effects and mechanisms on radiosensitivity unclear. Principal FindingsIn this study, we found significantly correlated with radioresistance longer telomere length human colorectal cell lines. Moreover, overexpression...
Abstract The precision and efficiency of the registration megavolt-level electronic portal imaging devices (EPID) images with naked eye in orthogonal window are reduced. This study aims to develop a new algorithm enhanced accuracy efficiency. Ten setup errors different translation rotation were simulated phantom. For each error, one set computer tomography EPID acquired registered traditional method. method was performed by two senior physicists Varian Offline Review software. is basing on...