A5055895362- MicroRNA in disease regulation
- Bone Tissue Engineering Materials
- Circular RNAs in diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Graphene and Nanomaterials Applications
- Adipose Tissue and Metabolism
- Cell Adhesion Molecules Research
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- Cholesterol and Lipid Metabolism
- Cancer, Hypoxia, and Metabolism
- Bone Metabolism and Diseases
- Biomarkers in Disease Mechanisms
- Nanoparticle-Based Drug Delivery
- RNA Research and Splicing
- Receptor Mechanisms and Signaling
- Angiogenesis and VEGF in Cancer
- Bone health and treatments
- Mesenchymal stem cell research
- Surface Modification and Superhydrophobicity
- Peroxisome Proliferator-Activated Receptors
- Telomeres, Telomerase, and Senescence
- Connective tissue disorders research
- Phytochemical Studies and Bioactivities
- Hydrogels: synthesis, properties, applications
Southern University of Science and Technology
2021-2025
Jinan University
2019-2024
Guangdong Medical College
2018-2023
Shenzhen Institutes of Advanced Technology
2023
Orthopaedic Research
2021
A novel sprayable adhesive is established (ZnMet-PF127) by the combination of a thermosensitive hydrogel (Pluronic F127, PF127) and coordination complex zinc metformin (ZnMet). Here we demonstrate that ZnMet-PF127 potently promotes healing traumatic skin defect burn injury promoting cell proliferation, angiogenesis, collagen formation. Furthermore, find ZnMet could inhibit reactive oxygen species (ROS) production through activation autophagy, thereby protecting from oxidative stress induced...
Tissue-engineered hydrogels have received extensive attention as their mechanical properties, chemical compositions, and biological signals can be dynamically modified for mimicking extracellular matrices (ECM). Herein, the synthesis of novel double network (DN) with tunable properties using combinatorial screening methods is reported. Furthermore, nanoengineered (NE) are constructed by addition ultrathin 2D black phosphorus (BP) nanosheets to DN multiple functions ECM microenvironment...
The development of recombinant protein cross-linked injectable hydrogels with good mechanical strength and effective drug loading capacity for bone regeneration is extremely attractive rarely reported. Here, we report the fabrication a smart hydrogel delivery system by incorporating rationally designed T4 lysozyme mutant (T4M) to mediate localized synergistic release Mg2+ Zn2+ repair. Apart from its intrinsic antibacterial properties, T4M bears abundant free amine groups on surface function...
Abstract Postmenopausal osteoporosis is a common bone metabolic disorder characterized by deterioration of the microarchitecture, leading to an increased risk fractures. Recently, circular RNAs (circRNAs) have been demonstrated play pivotal roles in regulating metabolism. However, underlying functions circRNAs metabolism postmenopausal remain obscure. Here, we report that circStag1 critical osteoporosis-related circRNA shows significantly downregulated expression osteoporotic marrow...
Underwater adhesives (UAs) have promising applications in diverse areas. However, traditional UAs several drawbacks such as weak and irreversible adhesion behaviors well poor performance biological environments. To address these challenges, we engineered a novel synthetic adhesive based on dynamic hydrophilic hydrophobic moieties, which shows very strong underwater strength (30–110 kPa) debonding energy (20–100 J/m2) to substrates. Interestingly, the could also be switched reversibly...
The bone marrow microenvironment contains heterogeneous stromal cells, which are critical for remodeling and provide essential supportive roles hematopoietic functions. Although the diversity of PDGFRα+β+ mesenchymal stromal/stem cells (MSCs) get consensus, osteo-lineage (OLCs) that constitute developmental trajectory osteoblasts largely remain unclear. Here, we construct a comprehensive atlas cell via performing integrative single analyses 77 samples from 14 datasets. Besides previously...
Osteoporosis (OP) is a systemic skeletal disease that primarily affects the elderly population, which greatly increases risk of fractures. Here we report Kindlin-2 expression in adipose tissue during aging and high-fat diet fed accompanied by decreased bone mass. specific deletion (K2KO) controlled Adipoq-Cre mice or tissue-targeting AAV (AAV-Rec2-CasRx-sgK2) significantly Mechanistically, promotes peroxisome proliferator-activated receptor gamma (PPARγ) activation downstream fatty acid...
The mammalian focal adhesion proteins Pinch1/2 activate integrins and promote cell–extracellular matrix migration; however, their roles in adipose tissue metabolism are unclear. Here we find that high-fat diet (HFD) feeding dramatically increases expression of white (WAT) mice. Furthermore, Pinch1 is largely upregulated WAT leptin-deficient ob/ob type 2 diabetic mice obese humans. While with loss adipocytes or global Pinch2 do not display any notable phenotypes, deleting globally...
Bone remodeling is a dynamic process between bone formation mediated by osteoblasts and resorption osteoclasts. Disrupted key factor in postmenopausal osteoporosis, metabolic disorder characterized deteriorated microarchitecture increased risk of fracture. Recent studies have shown that piwi-binding RNA (piRNA) involved the pathogenesis certain diseases at post-transcriptional level. Here, we analyzed piRNA-63049 (piR-63049), which may play an essential role remodeling. The expression...
Methyl protodioscin (MPD) is the main component of total diosgenin, which was reported to reduce cholesterol and triglyceride levels potentially. This study aimed investigate beneficial effects MPD against lipid disorder in hyperlipidemic gerbils induced by a high-fat diet (HFD). Hyperlipidemia feeding them with HFD for six weeks, daily oral dose solution (25 50 mg/kg/day) administered. investigated blood hepatic accumulation gerbils. The potential mechanism explored detecting expression...
Abstract Insufficient pancreatic β-cell mass and reduced insulin expression are key events in the pathogenesis of diabetes mellitus (DM). Here we demonstrate high Talin-1 β-cells that deficiency reduces proliferation, which leads to expression, thus causing glucose intolerance without affecting peripheral sensitivity mice. High-fat diet fed exerbates these phenotypes. Mechanistically, interacts with E3 ligase smad ubiquitination regulatory factor 1 (Smurf1), prohibits signal transducer...
HDL apoA-1-mediated cholesterol efflux pathway requires multiple cellular proteins and signal transduction processes, including adenylyl cyclase (AC)/cAMP signaling. Due to the existence of transmembrane AC isoforms, it was not known how many isoforms are expressed which ones essential for in macrophage foam cells. These questions were investigated THP-1 macrophages this study. Quantitative RT-PCR detected mRNAs all nine but only mRNA protein AC1 isoform consistently upregulated by loading...
The mammalian focal adhesion proteins Pinch1/2 activate integrins and promote cell-ECM migration; however, their roles in adipose tissue metabolism are unclear. Here we find that high fat diet (HFD) feeding dramatically increases expression of white tissues (WAT) mice. Furthermore, Pinch1 is largely up-regulated WAT the Leptin-deficient ob/ob type 2 diabetic mice obese humans. While with loss adipocytes or global Pinch2 do not display any notable phenotypes, deleting globally significantly...
The mammalian focal adhesion proteins Pinch1/2 activate integrins and promote cell-ECM migration; however, their roles in adipose tissue metabolism are unclear. Here we find that high fat diet (HFD) feeding dramatically increases expression of white tissues (WAT) mice. Furthermore, Pinch1 is largely up-regulated WAT the Leptin-deficient ob/ob type 2 diabetic mice obese humans. While with loss adipocytes or global Pinch2 do not display any notable phenotypes, deleting globally significantly...