A5024047382- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Pesticide Residue Analysis and Safety
- Pharmaceutical and Antibiotic Environmental Impacts
- Environmental Toxicology and Ecotoxicology
- Analytical Chemistry and Chromatography
- Pneumonia and Respiratory Infections
- Toxic Organic Pollutants Impact
- Pesticide and Herbicide Environmental Studies
- Malaria Research and Control
- Fish Biology and Ecology Studies
- Genetic diversity and population structure
- Fish Ecology and Management Studies
- Bacterial Identification and Susceptibility Testing
- Drug Transport and Resistance Mechanisms
- Aquaculture disease management and microbiota
- Microplastics and Plastic Pollution
- Water Treatment and Disinfection
- biodegradable polymer synthesis and properties
- Pesticide Exposure and Toxicity
- Analytical Methods in Pharmaceuticals
- Recycling and Waste Management Techniques
- Pharmacological Effects and Assays
- Turtle Biology and Conservation
- Effects and risks of endocrine disrupting chemicals
Chinese Academy of Fishery Sciences
2011-2024
Ministry of Agriculture and Rural Affairs
2018-2024
Shanghai Ocean University
2021-2024
Key Laboratory of Guangdong Province
2018-2022
The pharmacokinetics, tissue distribution, and elimination of enrofloxacin (ENR) its metabolite ciprofloxacin (CIP) were investigated to the crucian carp (Carassius auratus gibelio) after single (20 mg/kg b. w.) multiple oral administration b.w. one time daily for 5 days) at 28°C. concentrations ENR CIP in plasma tested tissues (muscle/skin, liver, kidney) detected simultaneously by high-performance liquid chromatography (HPLC), pharmacokinetic data analyzed with a non-compartmental model...
The pharmacokinetics of enrofloxacin (ENR) was studied in crucian carp ( Carassius auratus gibelio ) after single administration by intramuscular (IM) injection and oral gavage (PO) at a dose 10 mg/kg body weight 5 mg/L bath for hr 25°C. plasma concentrations ENR ciprofloxacin (CIP) were determined HPLC. Pharmacokinetic parameters calculated based on mean or CIP using WinNonlin 6.1 software. After IM, PO administration, the maximum concentration (C max 2.29, 3.24 0.36 μg/ml obtained 4.08,...
In this study, a multi-residue determination method of QuECHERS combined with UHPLC-MS/MS was developed to determine nine β-lactam antibiotics (penicillin G, amoxicillin, ampicillin, cephalexin, cefquinome, ceftiofur, cefazolin, cephapirin, cefuroxime) in aquaculture products. All the exhibited excellent linearity within range 2.0–200 ng/mL (cefuroxime: 5.0–200 ng/mL, r greater than 0.999), while limits detection (LODs) and quantification (LOQs) were 2.0–5.0 μg/kg 5.0–10.0 μg/kg,...
Abstract The study was carried out to evaluate the pharmacokinetic disposition of enrofloxacin (ENF) with a single dose 20 mg/kg after oral administration in largemouth bass ( Micropterus salmoides ) at 28°C. concentrations ENF and its metabolite ciprofloxacin (CIP) plasma, liver, muscle plus skin natural proportions were determined using HPLC. concentration–time data for plasma best described by two‐compartment open model. After administration, maximum concentration C max 10.99 μg/ml...
Pyrethroids pesticides (PPs) are the widely adopted synthetic for agriculture and fishery. The frequent use of these leads to accumulation residues in freshwater environments China, subsequently affecting aquatic organisms ecosystems. However, there few reports on toxicological risk assessment aquaculture products. In this study, uptake, depuration kinetics potential human health ecology fenpropathrin, cypermethrin, fenvalerate, deltamethrin were assessed using tilapia. results indicated...
Abstract The pharmacokinetic ( PK ) properties of enrofloxacin ENR and its metabolite ciprofloxacin CIP were investigated in crucian carp following oral administration at different dose levels (5, 10, 20, 40 mg/kg body weight). disposition kinetics was found to be linear over the range studied. Serum half‐lives ranged from 64.56 72.68 hr. vitro ex vivo activities serum against a pathogenic strain Aeromonas hydrophila determined. In bactericidal activity concentration dependent. Dosing 10...
The single‐dose disposition kinetics of the antibiotic marbofloxacin were determined in C hinese soft‐shelled turtles ( n = 10) after oral and intramuscular (i.m.) dose 10 mg/kg bodyweight. vitro ex vivo activities serum against a pathogenic strain A eromonas hydrophila determined. concentration‐dependent antimicrobial activity was confirmed for levels lower than 4 × MIC . For PK data, values AUC : minimum inhibitory concentration ) ratio 1166.6 782.4 h, respectively, i.m. dosing 0.05...
The comparative pharmacokinetics of enrofloxacin ( ENR ) and its metabolite ciprofloxacin CIP were investigated in healthy Aeromonas hydrophila ‐infected crucian carp after a single oral (p.o.) administration at dose 10 mg/kg 25 °C. plasma concentrations determined by HPLC . Pharmacokinetic parameters calculated based on mean noncompartmental modeling. In fish, the elimination half‐life T 1/2 λ z ), maximum concentration C max time to peak area under concentration–time curve AUC values 64.66...
Phosphogypsum, as a byproduct of wet-process phosphoric acid reaction, has caused many environmental pollution problems. To improve the property and purity phosphogypsum in process, liquid-solid-liquid three-phase hydrolysis synergistic extraction reaction system was established by adding certain amount extractant actual production process. In order to study effect residue impurities system, phase, morphology, impurity occurrences were systematically analyzed. The results showed that when...
The pharmacokinetics of cefquinome was studied in plasma after a single dose (10 mg/kg) intramuscular (i.m.) or intraperitoneal (i.p.) administration to tilapia ( Oreochromis niloticus ) freshwater at 30 °C. Ten fish per sampling point were examined treatment. data fitted two‐compartment open models following both routes administration. estimates total body clearance (CL/F), volume distribution (Vd/F), and absorption half‐life (T 1/2ka 0.049 0.037 L/h/kg, 0.41 0.33 L/kg, 0.028 0.035 h i.m....
Microsatellite DNAs were used to analyze the variations and structures of three geographic populations Cirrhina molitorella in Xijinag (XJ), Beijiang (BJ), Dongjiang (DJ) Pearl River Basin as well one cultured population. The genetic diversity was calculated using microsatellites. This data revealed high both wild C. molitorella, with average He ranging from 0.7081 0.7723. analysis molecular variance (amova) showed that only 5.76% among populations, whereas 94.24% within populations. Exact...
The pharmacokinetics ( PK ) of cefquinome CEQ was studied in crucian carp Carassius auratus gibelio after single oral, intramuscular (i.m.), and intraperitoneal (i.p.) administration at a dose 10 mg/kg body weight following incubation 5 mg/L bath for hr 25°C. plasma concentration determined using high‐performance liquid chromatography HPLC ). parameters were calculated based on mean WinNonlin 6.1 software. disposition i.m., or i.p. best described by two‐compartment open model with...
Thirteen polymorphic microsatellite markers were used to study the genetic variation of Ptychidio jordani sampled from three sites Liuzhou, Guiping and Yunan in Pearl River Basin with help local fishers. Allele numbers ranged 2 19 fragment sizes 108 288. Average polymorphism information content (PIC), average observed heterozygosity (Ho) expected (He) 0.439917, 0.4147 0.4986, respectively, which indicate a comparatively high level diversity. The coefficient differentiation (Gst) between two...
A simple, sensitive, and simultaneous method was established validated for the active clinical components of teicoplanin ramoplanin in environmental water by LC-MS/MS coupled with cascade elution. Moreover, a elution method, which rapid, solvent-less, high-extraction efficient successfully proposed to realize extraction purification seven targets one step. Under optimized conditions, showed excellent linearity correlation coefficient ( R 2 ) ≥0.998 range 1.0–100.0 ng L −1 . Low matrix...