A5063051049- Pain Mechanisms and Treatments
- Healthcare and Venom Research
- Inflammasome and immune disorders
- Herpesvirus Infections and Treatments
- Pharmacological Effects of Natural Compounds
- Cancer-related molecular mechanisms research
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Inflammatory mediators and NSAID effects
- Cancer, Stress, Anesthesia, and Immune Response
- Respiratory Support and Mechanisms
- Ion channel regulation and function
- Circular RNAs in diseases
- Neurological Disease Mechanisms and Treatments
- Pain Management and Opioid Use
- Curcumin's Biomedical Applications
- Toxin Mechanisms and Immunotoxins
- Sirtuins and Resveratrol in Medicine
- Sympathectomy and Hyperhidrosis Treatments
- Epigenetics and DNA Methylation
- Vector-borne infectious diseases
- Cytokine Signaling Pathways and Interactions
- RNA modifications and cancer
- Neuroscience and Neuropharmacology Research
- Axon Guidance and Neuronal Signaling
Jiaxing University
2016-2025
First Hospital of Jiaxing
2015-2024
Zhejiang University
2023
Nanchang University
2021
Southeast University
2017
Tianjin University of Science and Technology
2014
Tianjin University
2014
Soochow University
2011-2012
Despite accumulating evidence on the role of glial cells and their associated chemicals in mechanisms pain, few studies have addressed potential chemokines descending facilitation chronic pain. We aimed to study hypothesis that CXCL1/CXCR2 axis periaqueductal gray (PAG), a co-restructure nociceptive system, is involved pain facilitation. Intramedullary injection Walker 256 mammary gland carcinoma adult female Sprague Dawley rats was used establish bone cancer (BCP) model. RT-PCR, Western...
Bone cancer pain (BCP) is an intractable clinical problem, and lacked effective drugs for treating it. Recent research showed that several chemokines in the spinal cord are involved pathogenesis of BCP. In this study, antinociceptive effects liquiritin, which active component extracted from Glycyrrhizae Radix, were tested underlying mechanisms targeting dorsal horn (SDH) investigated. The BCP group displayed a significant decrease mechanical withdrawal threshold on days 6, 12, 18 when...
Rationale: Osteoarthritis (OA) is a chronic joint disorder with limited treatment efficacy, necessitating innovative therapeutic strategies. This study explores one-pot-synthesized gelatin microspheres devoid of glutaraldehyde as novel biomaterial for OA management. Focusing on the Ext1 gene, critical cartilage development and downregulated in OA, we investigated its restoration immune regulation using cultured mesenchymal stem cells (MSCs). Methods: patients undergoing knee replacement...
Background: Cancer-induced bone pain (CIBP) is one of the most challenging clinical problems due to a lack understanding mechanisms. Recent evidence has demonstrated that activation microglial G-protein-coupled P2Y 12 receptor (P2Y R) and proinflammatory cytokine production play an important role in neuropathic generation maintenance. However, whether R involved CIBP remains unknown. Methods: The purpose this study was investigate its molecular Using cancer model inoculated with Walker 256...
Bone cancer pain (BCP) is a pervasive clinical symptom which impairs the quality life. Long noncoding RNAs (lncRNAs) are enriched in central nervous system and play indispensable roles numerous biological processes, while its regulatory function nociceptive information processing remains elusive. Here, we reported that functional modulatory role of ENSRNOT00000071132 (lncRNA71132) BCP process sponging with miR-143 downstream GPR85-dependent signaling cascade. Spinal lncRNA71132 was...
Nanobodies are single-domain antibodies that contain the unique structural and functional properties of naturally-occurring heavy chain in camelidae. As a novel class antibody, they show many advantages compared with traditional such as smaller size, higher stability, improved specificity, more easily expressed microorganisms. These unusual hallmarks make them promising tools basic research clinical practice. Although thousands nanobodies known to be published, no single database provides...
Interleukin-33 (IL-33), belonging to IL-1 family cytokines, has been reported participate in cancer growth and metastasis. The clinical values of IL-33 lung have previously investigated. We aimed elucidate the probable role migration invasion cells.Cell invasiveness were tested by Transwell assay. Western blotting analysis was performed detect protein expression.We found that treatment human A549 cells dose-dependently enhanced their migratory invasive ability, accompanied elevated...
The hepatocyte nuclear factor 4 gamma (HNF4G), a member of orphan receptors, is up-regulated and functions as an oncoprotein in bladder cancer. In the present study, we observed that HNF4G expression was elevated lung cancer tissues compared to adjacent normal tissues. protein correlated with tumor size prognosis patients. Transfection small interference RNA (siRNA) targeting two cell lines (H358 H292 cells) significantly inhibited proliferation via arresting cells at G1 phase inducing...
Abstract Curcumin has a variety of anticancer properties, but low bioavailability prevents its use in chemotherapeutic applications. To address this problem, we tested the efficacy synthetic curcumin analog B14 breast cancer cells and explored mechanism by which inhibits proliferation metastasis cells. We used cell line MCF‐7, MDA‐MB‐231 to study effects assessed viability, migration invasion, cycle, apoptosis, addition, antitumor effect vivo was examined mice bearing found that, as...
As the population ages and medical technology advances, anesthesia procedures for elderly patients are becoming more common, leading to an increased prevalence of postoperative cognitive dysfunction. However, etiology correlation between gut microbiota dysfunction poorly understood, research in this area is limited. In study, mice with were found have reduced levels fatty acid production anti-inflammatory flora gut, Bacteroides was associated depression, depression. Furthermore, specific...
Bone cancer pain (BCP) is a serious clinical problem that affects the quality of life patients. However, current treatment methods for this condition are still unsatisfactory. This study investigated whether intrathecal injection rosiglitazone modulates noxious behaviors associated with BCP, and possible mechanisms related to effect were explored. We found relieved bone cancer-induced mechanical hyperalgesia in dose-dependent manner, promoted expression peroxisome proliferator-activated...
This investigation aims to evaluate the effectiveness of paravertebral injection recombinant human interferon-α2b in conjunction with high-voltage, long-term pulsed radiofrequency (PRF) DRG mitigation postherpetic neuralgia (PHN). retrospective study was performed on 84 individuals suffering from acute PHN. The participants were divided into three groups. Group H: Treat combined high-voltage PRF; C: I: interferon-α2b. All patients groups orally administered 5 mg morphine hydrochloride...
Background: Bone cancer pain (BCP) represents one of the most challenging comorbidities associated with metastasis. Long non-coding RNAs (lncRNAs) have garnered attention as potential therapeutic agents in managing neuropathic pain. However, their role regulation nociceptive information processing remains poorly understood. In this study, we observed a significant down-regulation spinal lncRNA ENSRNOG00000051325 (lncRNA51325) rat model bone Our study sought to elucidate involvement...
Chronic, inflammatory pain is an international health concern that severely diminishes individuals' quality of life. Catalpol iridoid glycoside derived from the roots Rehmannia glutinosa possesses anti-inflammatory, antioxidant, and neuroprotective properties for treating multiple kinds disorders. Nevertheless, catalpol's impacts on its potential methods action are still unclear. The purpose this investigation to determine mechanism catalpol reduce behaviors in a rat model with complete...
Recently, epigenetics involved in the regulation of gene expression has become a research hotspot. This study evaluated N4-acetylcytidine (ac4c) RNA acetylation spinal dorsal horn (SDH) rats with cancer-induced bone pain (CIBP). The ac4C-specific RIP sequencing and NAT10-specific were performed to identify differences ac4C SDH between CIBP sham groups, relationship acetylation-modifying enzyme NAT10, association analysis was performed. By interfering NAT10 expression, some up-regulated genes...
Curcumin has several pharmacological properties such as anti-inflammatory, antioxidant, and neuroprotective activities. B14 is a curcumin analogue considered to be more potent compound with preserved pharmacodynamic Based on the previous research studies, janus-activated kinase 2 (JAK2)/signal transducer activator of transcription 3 (STAT3) signaling pathway plays remarkable role in inflammation, chronic pain, even contributes pathogenesis neuropathic pain. Pro-inflammatory cytokines...
Herpes zoster (HZ), commonly called shingles, it is a distinctive syndrome caused by reactivation of varicella virus (VZV). A better understanding the biological characteristics HZ patients can help develop new targeted therapies to improve prognosis. High-throughput proteomics technology deeply study molecular changes in development and progression disease integrate different levels information, this important make clinical decisions. Circulating blood contains lot we conducted patient...
The tyrosine kinases of Src family play an important role in the central sensitization following peripheral inflammation. However, whether arcuate nucleus (ARC) mediobasal hypothalamus is involved remains unknown. aim this study was to investigate and mechanisms N-methyl-d-aspartate (NMDA) receptor activity ARC Peripheral inflammation induced by unilateral injection complete Freund's adjuvant (CFA) into rat hindpaw. neuronal activities were recorded using electrophysiological field recording...