A5100701022- Liver physiology and pathology
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Cancer Research and Treatments
- Phagocytosis and Immune Regulation
- Crystallization and Solubility Studies
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- RNA Research and Splicing
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced Breast Cancer Therapies
- X-ray Diffraction in Crystallography
- Peptidase Inhibition and Analysis
- Cancer Genomics and Diagnostics
Zhejiang University
2018-2025
First Affiliated Hospital Zhejiang University
2019-2025
Yanbian University
2019-2024
Capital University of Physical Education and Sports
2010-2024
China Medical University
2022-2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2022-2024
China West Normal University
2017-2024
Shanghai University of Traditional Chinese Medicine
2022-2024
Shanghai Clinical Research Center
2021-2023
Zhejiang Cancer Hospital
2021-2023
Objective Hepatocellular carcinoma (HCC) is heterogeneous, especially in multifocal tumours, which decreases the efficacy of clinical treatments. Understanding tumour heterogeneity critical when developing novel treatment strategies. However, a comprehensive investigation HCC lacking, and available evidence regarding has not led to improvements practice. Design We harvested 42 samples from eight patients evaluated using whole-exome sequencing, RNA mass spectrometry-based proteomics...
Notwithstanding the numerous drugs available for liver cancer, emerging evidence suggests that chemotherapeutic resistance is a significant issue. HGF and its receptor MET play critical roles in carcinogenesis metastasis, mainly dependent on activity of tyrosine kinase. However, unknown reasons, all HGF-MET kinase activity-targeted have failed or been suspended clinical trials thus far. Macroautophagy/autophagy protective 'self-eating' process resisting metabolic stress by recycling obsolete...
Although mRNA vaccines have been effective against multiple cancers, their efficacy pancreatic adenocarcinoma (PAAD) remains undefined. Accumulating evidence suggests that immunotyping can indicate the comprehensive immune status in tumors and microenvironment, which is closely associated with therapeutic response vaccination potential. The aim of this study was to identify potent antigens PAAD for vaccine development, further distinguish subtypes construct an landscape selecting suitable...
The mRNA-based cancer vaccine has been considered a promising strategy and the next hotspot in immunotherapy. However, its application on cholangiocarcinoma remains largely uncharacterized. This study aimed to identify potential antigens of for development anti-cholangiocarcinoma mRNA vaccine, determine immune subtypes selection suitable patients from an extremely heterogeneous population.Gene expression profiles corresponding clinical information were collected GEO TCGA, respectively....
Abstract Metabolic reprogramming refers to the ability of a cell alter its metabolism in response different stimuli and forms pressure. It helps cells resist external stress provides them with new functions. Skin wound healing involves metabolic nutrients, such as glucose, lipids, amino acids, which play vital roles proliferation, differentiation, migration multiple types. During glucose process wounds, transporters key enzymes cause elevated metabolite levels. Glucose-mediated oxidative...
Abstract PD-1 (CD279)–PD-L1 (CD274) inhibitory signaling is critical for cancer immune evasion, and thus has become one of the major targets in anticancer immunotherapy. There are several studies that demonstrate potent effects posttranslational modifications CD274 on inactivation suppression, such as ubiquitination, phosphorylation, glycosylation, palmitoylation. However, regulatory mechanisms deubiquitination still largely unclear. Here, we identified ubiquitin-specific protease 22 (USP22)...
Abstract Despite the substantial impact of post-translational modifications on programmed cell death 1 ligand (PD-L1), its importance in therapeutic resistance pancreatic cancer remains poorly defined. Here, we demonstrate that never mitosis gene A-related kinase 2 (NEK2) phosphorylates PD-L1 to maintain stability, causing PD-L1-targeted immunotherapy have poor efficacy. We identify NEK2 as a prognostic factor immunologically “hot” cancer, involved onset and development tumors an...
Abstract Background Adipose mesenchymal stem cell-derived exosomes (ADSC-Exos) have great potential in the field of tissue repair and regenerative medicine, particularly cases refractory diabetic wounds. Interestingly, autophagy plays a role wound healing, recent research has demonstrated that are closely associated with intracellular biogenesis molecular signaling mechanisms. Therefore, this study aimed to investigate whether ADSC-Exos promote wounds by regulating provide new method...
Mir-29 microRNA families are involved in regulation of various types cancers. Although was shown to play an inhibitory role tumorigenesis, the breast cancer still remains obscure. In this study, we showed that Mir-29a is dominant isoform its family mammary cells and expression down-regulated different Furthermore, over-expression resulted significant slower growth caused higher percentage at G0/G1 phase. Consistent with data, knockdown normal lead cell rate, entering S We further found...
Dysregulated expression and activation of receptor tyrosine kinases (RTKs) are associated with a range human cancers. However, current RTK-targeting strategies exert little effect on pancreatic cancer, highly malignant tumor complex immune microenvironment. Given that immunotherapy for cancer still remains challenging, this study aimed to elucidate the prognostic role RTKs in tumors different immunological backgrounds investigate their targeting potential immunotherapy.Kaplan-Meier plotter...
As a systemic disease, osteoporosis (OP) results in bone density loss and fracture risk, particularly the hip vertebrae. However, underlying molecular mechanisms of OP development have not been fully illustrated. N6-Methyladenosine (m6A) is most abundant modification mRNAs, which involved many pathological processes aging disease. its role regulatory mechanism remains unknown. Here, we aimed to investigate roles m6A demethylase FTO development. The showed that methylated RNA level was...
Abstract Cancer cell metabolism contributes to the establishment of an immunosuppressive tumor microenvironment. Aberrant expression CD73, a critical enzyme in ATP metabolism, on surface results extracellular accumulation adenosine, which exhibits direct inhibitory effects tumor-infiltrating lymphocytes. However, little is known about influence CD73 negative immune regulation-associated signaling molecules and transduction pathways inside cells. This study aims demonstrate moonlighting...