A5035399790- Chromosomal and Genetic Variations
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- interferon and immune responses
- Cytomegalovirus and herpesvirus research
- Plant Virus Research Studies
- Viral-associated cancers and disorders
- CRISPR and Genetic Engineering
- Herpesvirus Infections and Treatments
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic Syndromes and Imprinting
- Traditional Chinese Medicine Studies
- Genetic factors in colorectal cancer
- Chronic Lymphocytic Leukemia Research
- Genomics and Rare Diseases
- Memory and Neural Mechanisms
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Colorectal Cancer Screening and Detection
- Radiomics and Machine Learning in Medical Imaging
- Evolution and Genetic Dynamics
- vaccines and immunoinformatics approaches
- Bat Biology and Ecology Studies
Pacific Northwest Diabetes Research Institute
2019-2024
Peking University Cancer Hospital
2023-2024
Harbin Medical University
2024
Southwest Medical University
2024
Jiaxing University
2023-2024
Peking University
2023-2024
Tongji University
2024
Huazhong Agricultural University
2024
Tianjin Nankai Hospital
2024
Tianjin Medical University
2024
Less than half of individuals with a suspected Mendelian condition receive precise molecular diagnosis after comprehensive clinical genetic testing. Improvements in data quality and costs have heightened interest using long-read sequencing (LRS) to streamline genomic testing, but the absence control datasets for variant filtering prioritization has made tertiary analysis LRS challenging. To address this, 1000 Genomes Project ONT Sequencing Consortium aims generate from at least 800 samples....
Fewer than half of individuals with a suspected Mendelian or monogenic condition receive precise molecular diagnosis after comprehensive clinical genetic testing. Improvements in data quality and costs have heightened interest using long-read sequencing (LRS) to streamline genomic testing, but the absence control datasets for variant filtering prioritization has made tertiary analysis LRS challenging. To address this, 1000 Genomes Project ONT Sequencing Consortium aims generate from at least...
Gene number difference among organisms demonstrates that new gene origination is a fundamental biological process in evolution. Exon shuffling has been universally observed the formation of genes. Yet to be learned are ways exons originate and evolve, how often appear. To address these questions, we identified 2695 newly evolved mouse rat by comparing expressed sequences 12,419 orthologous genes between human mouse, using 743,856 pig ESTs as outgroup. The exon rate about 2.71 × 10 -3 per...
Host-virus arms races are inherently asymmetric; viruses evolve much more rapidly than host genomes. Thus, there is high interest in discovering mechanisms by which genomes keep pace with evolving viruses. One family of restriction factors, the APOBEC3 (A3) cytidine deaminases, has undergone positive selection and expansion via segmental gene duplication recombination. Here, we show that new copies A3 genes have also been created primates reverse transcriptase-encoding elements like LINE-1...
Mammalian genomes comprise many active and fossilized retroelements. The obligate requirement for retroelement integration affords host an opportunity to 'domesticate' genes their own purpose, leading important innovations in genome defense placentation. While such exaptations involve retroviruses, the L1TD1 gene is only known domesticated whose protein-coding sequence almost entirely derived from a LINE-1 (L1) retroelement. Human has been shown play role pluripotency maintenance. To...
Human Endogenous Retrovirus type K (HERV-K) is the only HERV known to be insertionally polymorphic; not all individuals have a retrovirus at specific genomic location. It possible that HERV-Ks contribute human disease because people differ in both number and location of these retroviruses. Indeed viral transcripts, proteins, antibody against HERV-K are detected cancers, auto-immune, neurodegenerative diseases. However, attempts link polymorphic with any been frustrated part population...
L1 retrotransposons have co-evolved with their mammalian hosts for the entire history of mammals and currently compose ~ 20% a genome. B1 are dependent on retrotransposition span evolutionary rodents since radiation. L1s were found to lost activity in group South American rodents, Sigmodontinae, inactivation preceded extinction same group. Consequently, basal sigmodontines active but inactive B1s derived clade both B1s. It has been suggested that became extinct during long period quiescence...
Recently, epigenetics involved in the regulation of gene expression has become a research hotspot. This study evaluated N4-acetylcytidine (ac4c) RNA acetylation spinal dorsal horn (SDH) rats with cancer-induced bone pain (CIBP). The ac4C-specific RIP sequencing and NAT10-specific were performed to identify differences ac4C SDH between CIBP sham groups, relationship acetylation-modifying enzyme NAT10, association analysis was performed. By interfering NAT10 expression, some up-regulated genes...
Although L1 sequences are present in the genomes of all placental mammals and marsupials examined to date, their activity was lost megabat family, Pteropodidae, ∼24 million years ago. To examine characteristics L1s prior extinction, we analyzed evolutionary history genome a megabat, Pteropus vampyrus, found pattern periodic expansion quiescence. In contrast well-characterized human mouse, have accommodated two or more simultaneously active families throughout history, major peaks deposition...
Large granular lymphocyte (LGL) leukemia is an uncommon cancer characterized by sustained clonal proliferation of LGL cells. Antibodies reactive to retroviruses have been documented in the serum patients with leukemia. Culture or molecular approaches date not successful identifying a retrovirus. Because retrovirus must integrate into genome infected cell, we focused our efforts on detecting novel integration site clonally expanded We present new computational tool that uses long-insert mate...
Neuroblastoma is a lethal childhood solid tumor of developing peripheral nerves. Two percent children with neuroblastoma develop opsoclonus myoclonus ataxia syndrome (OMAS), paraneoplastic disease characterized by cerebellar and brainstem-directed autoimmunity but typically outstanding cancer-related outcomes. We compared transcriptomes tumor-infiltrating T B cell repertoires from 38 OMAS subjects to 26 non-OMAS-associated neuroblastomas. found greater infiltration in OMAS-associated tumors...
This study aimed to evaluate the efficacy and safety of buccal acupuncture on postoperative analgesia, perioperative stress response adverse events in elderly patients undergoing laparoscopic radical gastrectomy.
Phosphatidic acid (PA) is considered as a second messenger that interacts with protein kinases, phosphatases and NADPH oxidases, amplifying the signal to initiate plant defense signaling responses (Li Wang, 2019). In rice, mutation of RBL1 causes accumulation PA, enhancing multipathogen resistance (Sha et al., 2023). our previous study, we attempted rescue rbl1 mutant by overexpressing phosphatidate phosphohydrolase ( PAH ) genes. However, overexpression PAH2 reduced PA level but did not...
To determine whether risk stratification can optimize the benefits of flexible sigmoidoscopy (FSG) screening.
Abstract The activity of the retrotransposon LINE-1 has created a substantial portion human genome. Most this sequence comprises fractured and debilitated LINE-1s. An accurate approximation number, location, elements present in any single genome proven elusive due to difficulty assembling phasing repetitive polymorphic regions Through an in-depth analysis publicly-available, deep, long-read assemblies nearly homozygous genomes, we defined location all intact LINE-1s these assemblies. We...
Abstract All vertebrate genomes have been colonized by retroviruses along their evolutionary trajectory. Although endogenous (ERVs) can contribute important physiological functions to contemporary hosts, such benefits are attributed long-term coevolution of ERV and host because germline infections rare expansion is slow, the effectively silences them. The several outbred species including mule deer (Odocoileus hemionus) currently being ERVs, which provides an opportunity study dynamics at a...
Whole genome doublings (WGD), a hallmark of human cancer, is pervasive in breast cancer patients. However, the molecular mechanism complete impact WGD on survival and treatment response remains unclear. To address this, we performed comprehensive systematic analysis WGD, aiming to identify distinct genetic alterations linked highlight its improvement clinical outcomes for cancer. A linear regression model along with weighted gene co-expression network (WGCNA) was applied The Cancer Genome...
Cancer-induced bone pain (CIBP) significantly impacts the quality of life and survival patients with advanced cancer. Despite established role neurexins in synaptic structure function, their involvement sensory processing during injury has not been extensively studied. In this study using a rat model CIBP, we observed increased neurexin 2 expression spinal cord neurons. Knockdown reversed CIBP-related behaviors, sensitization c-Fos neurons, pain-related negative emotional behaviors....
<title>Abstract</title> Immune cells play a crucial role in the pathogenesis of herpes zoster virus infection, yet their precise contribution to disease progression remains incompletely understood. In this study, we used single-cell sequencing analyze distribution peripheral blood mononuclear (PBMCs) according different stages zoster. Our findings demonstrated detailed immune cell profile onset and recovery from zoster, revealing proportion alterations subpopulations. Gene expression...
Anaplastic thyroid carcinoma is one of the highly fatal cancers and poses a serious threat to human health. Ferroptosis has been widely studied proved have an important role in tumor suppression, providing new avenues for cancer therapy; glutathione peroxidase 4(GPX4) selenoprotein thioredoxin reductase(TXNRD1) are regulatory targets ferroptosis.Warburg effect energy sources hypermetabolism, pyruvate kinase isoenzyme 2 (PKM2) key metabolism enzyme that this effect. Shikonin(SKN) Chinese herb...