A5101474658- Telomeres, Telomerase, and Senescence
- BRCA gene mutations in cancer
- Advanced biosensing and bioanalysis techniques
- Obstructive Sleep Apnea Research
- Gastric Cancer Management and Outcomes
- Cardiac Ischemia and Reperfusion
- DNA Repair Mechanisms
- Bioactive Natural Diterpenoids Research
- Endoplasmic Reticulum Stress and Disease
- Pregnancy and preeclampsia studies
- Neonatal Respiratory Health Research
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- Cancer Mechanisms and Therapy
- Hernia repair and management
- Respiratory Support and Mechanisms
- Nutrition, Genetics, and Disease
- Cancer, Stress, Anesthesia, and Immune Response
- Pancreatic function and diabetes
- Health Promotion and Cardiovascular Prevention
- Anesthesia and Neurotoxicity Research
- Phagocytosis and Immune Regulation
- Melanoma and MAPK Pathways
- Pregnancy and Medication Impact
- RNA regulation and disease
Fujian Medical University
2018-2024
Zhangzhou Municipal Hospital of Fujian Province
2018-2024
Weatherford College
2023
Sir Run Run Shaw Hospital
2023
Fujian Provincial Hospital
2019-2023
Union Hospital
2022
Jilin University
2019-2022
Second Military Medical University
2017-2018
Changhai Hospital
2017-2018
Guangzhou University
2016
Abstract The highly heterogeneous characteristics of Wharton's jelly mesenchymal stem cells (WJ‐MSCs) may be responsible for the poor clinical outcomes and reproducibility treatments based on WJ‐MSCs. Exploration WJ‐MSC heterogeneity with multimodal single‐cell technologies will aid in establishing accurate MSC subtyping developing screening protocols dominant functional subpopulations. Here, WJ‐MSCs are systematically analyzed by single cell spatial transcriptome sequencing. Single‐cell...
Abstract The nucleolar protein PinX1 has been proposed to be a putative tumor suppressor due its binding and inhibition of the catalytic activity telomerase, an enzyme that is highly expressed in most human cancers which it counteracts telomere shortening–induced senescence confer cancer cell immortalization. However, role regulation, as well cancer, still poorly understood. In this study, we showed constitutively various cells regardless their telomerase malignant status. Most...
Telomerase maintains telomere length and has been implicated in both aging carcinogenesis of human cells. This enzyme is a specialized ribonucleoprotein (RNP) complex, minimally consisting two essential components: the protein catalytic subunit TERT (telomerase reverse transcriptase) integral RNA moiety TR RNA, TERC). Both have found to localize nucleoli within nucleus, leading suggestion as site for telomerase RNP biogenesis However, whether this statement true or not yet convincingly...
Abstract Background Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease caused by severe loss of pancreatic β cells. Immune cells are key mediators cell destruction. This study attempted to investigate the role immune and immune-related genes in occurrence development T1DM. Methods The raw gene expression profile samples from 12 T1DM patients 10 normal controls was obtained Gene Expression Omnibus (GEO) database. Differentially expressed (DEGs) were identified Limma package R....
With significant high incidence and death rates, liver cancer has become one of the most common cancers all over world. Hence, novel strategies are needed for management this malignancy. Apoptotic related proteins Noxa Puma members BH3-only family. In study, human or coding sequences have been inserted into plasmid pcDNA 3.1 regulated by TERT promoter. The transfection HepG2 cells with pcTERT-Noxa pcTET-Puma resulted in suppression cell proliferation as well finally led to apoptosis via...
Compared with young patients, elderly patients gastric cancer usually have lower muscle mass, poorer nutritional status, immunity, and worse cardiopulmonary function. Therefore, how to improve the prognosis of after laparoscopic-assisted radical gastrectomy is focus difficulty clinician. The aim our study was investigate risk factors for postoperative complications these patients. data aged ≥ 60 years who underwent were analyzed. Univariate used determine potential then multivariate analyses...
Esophageal squamous cell carcinoma accounts for a large proportion of cancer-associated mortalities in both men and women. Melittin is the major active component bee venom, which has been reported to possess anti-inflammatory, antibacterial anti-cancer properties. The aim present study was construct tumor targeted recombinant plasmid [pc-telomerase reverse transcriptase (TERT)-melittin] containing human TERT promoter followed by melittin coding sequence explore effects this esophageal...
The sarcolemmal ATP-sensitive K+ (sarcKATP) channel plays a cardioprotective role during stress. However, the of sarcKATP in apoptosis cardiomyocytes and association with mitochondrial calcium remains unclear. For this purpose, we developed model LPS-induced sepsis neonatal rat (NRCs). TUNEL assay was performed order to detect cardiac myocytes MTT determine cellular viability. Exposure LPS significantly decreased viability NRCs as well expression Bcl-2, whereas it enhanced activity...
The database of BRCA1/2 mutations in Chinese population remains incomplete at present. Therefore, the present study aimed to report specific harmful and discuss clinicopathological features mutation carriers. germline tests for 71 patients with breast cancer from a hereditarily high‑risk were performed using next‑generation sequencing identification deleterious mutations. Furthermore, between carriers non‑carriers compared. A total 13/71 (18.3%) carried BRCA1 or BRCA2 (7 6 BRCA2). incidence...
Introduction The total extraperitoneal (TEP) laparoscopic repair of a groin hernia is increasingly being used because less pain, rapid recovery, and low recurrence rate, but different variants surgical approaches for TEP are reported by number centers the merits demerits associated with each approach not well described. aim this study was to compare clinical outcome totally inguinal hernioplasty 4 approach. Methods Between August 2004 March 2008, 99 patients unilateral who underwent without...
The comparison of freshly collected breast cancer tissue DNA with that the matched blood specimens 144 patients was studied, and from 30 unrelated normal women without selected as controls. entire BRCA1 coding sequence amplified by PCR primers especially designed for comprehensive mutation screening single-strand conformation polymorphism (SSCP) analysis. Amplification electrophoresis were repeated confirmation altered migration patterns. Variant bands subsequently cut gels, resuspended in...
Abstract Objective In this study, we investigated the safety and practicability of ultra‐fast track anesthesia (UFTA) for endoscopic thoracic sympathectomy (ETS). Methods A total 72 patients with palmar hyperhidrosis undergoing ETS were randomly divided into three groups: UFTA group (group I), single‐lumen tracheal intubation local infiltration technique II), routine III). Mean arterial pressure (MAP) heart rate (HR) recorded all groups at following six time points: Before anesthetics...
Learning points for cliniciansMacroscopic T-wave alternans (TWA) signifies significant vulnerability during repolarization and may be a harbinger of impending electrical instability.Although macroscopic TWA is not frequently encountered in routine clinical practice.Prompt identification essential proper management prevention malignant ventricular arrhythmias sudden cardiac death.
Liver cancer is an aggressive malignancy with exhibits both high mortality and morbidity. The current treatment options are associated several limitations, novel specific anti-cancer drugs urgently needed to improve liver treatment. In this study, a new peptide KK-64 was designed, it showed strong cytotoxicity against cells. To obtain the tumor targeting property, plasmid that contains DNA fragment driven by human telomerase reverse transcriptase (hTERT) promoter constructed. pcTERT-kk-64...