A5101426276- Optical Imaging and Spectroscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Non-Invasive Vital Sign Monitoring
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Infrared Thermography in Medicine
- Digital Radiography and Breast Imaging
- Thermoregulation and physiological responses
- Optical Coherence Tomography Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Advanced Optical Sensing Technologies
- Calibration and Measurement Techniques
- Advanced X-ray Imaging Techniques
- Advanced Image Fusion Techniques
- Emotion and Mood Recognition
- Hemodynamic Monitoring and Therapy
- Face recognition and analysis
- Advanced MRI Techniques and Applications
- Ultrasound Imaging and Elastography
- Spectroscopy and Laser Applications
- Thermography and Photoacoustic Techniques
- Service-Oriented Architecture and Web Services
- Radiation Dose and Imaging
- Advanced Computational Techniques and Applications
- Photodynamic Therapy Research Studies
Fudan University
2025
Huazhong University of Science and Technology
2021-2024
Tsinghua University
2024
Ji Hua Laboratory
2024
Zhangzhou Municipal Hospital of Fujian Province
2024
Fujian Medical University
2024
Hohai University
2023
Tianjin Agricultural University
2022-2023
Fiberhome Technology Group (China)
2021-2023
Hebei Normal University
2022
Micro-expressions are spontaneous, rapid and subtle facial movements that can neither be forged nor suppressed. They very important nonverbal communication clues, but transient of low intensity thus difficult to recognize. Recently deep learning based methods have been developed for micro-expression (ME) recognition using feature extraction fusion techniques, however, targeted efficient still lack further study according the ME characteristics. To address these issues, we propose a novel...
The optical differential pathlength factor (DPF) is an important parameter for physiological measurement using near infrared spectroscopy, but the human adult head it has been available only forehead. Here we report measured DPF results forehead, somatosensory motor and occipital regions from measurements on 11 volunteers a time-resolved imaging system. optode separation was about 30 mm wavelengths used were 759 nm, 799 nm 834 nm. Measured DPFs 7.25 central forehead 6.25 temple region at For...
In the field of diffuse optical tomography (DOT), it is widely accepted that time-resolved (TR) measurement can provide richest information on photon migration in a turbid medium, such as biological tissue. However, currently available image reconstruction algorithms for TR DOT are based mostly cw component or some featured data types original temporal profiles, which related to solution time-independent diffusion equation. Although this methodology greatly simplify process, suffers from low...
Bound states in the continuum (BIC) represent distinct non-radiative endowed with infinite lifetime and vanishing resonance linewidth. Introducing asymmetric perturbation to system can convert true BICs into high quality leaky modes which is useful many photonic applications. Previously, such of interest only limited a single factor. However, different perturbations by unit cell gap, geometry rotation angle result distinctive modes. The combination two factors excite multi-mode contributed...
Immunoglobulin G (IgG) N-glycans have been identified as associated with aging; however, previous studies predominantly quantified changes based on the relative percentages of each glycan within total pool, neglecting absolute concentration individual glycans. Additionally, quantification can limit practical applications, these often require measurements for consistent and interpretable biomarker values. In this study, we introduce a novel strategy discovering aging-associated IgG glycans...
Fluorescence diffuse optical tomography (DOT) has attracted many attentions from the community of biomedical imaging, since it provides effective enhancement in imaging contrast. This modality is now rapidly evolving as a potential means monitoring molecular events small living organisms with help molecule-specific contrast agents, referred to fluorescence (FMT). FMT could greatly promote pathogenesis research, drug development, and therapeutic intervention. Although steady-state...
There has been recently a considerable interest in simultaneously reconstructing yield and lifetime distributions of fluorescent imaging agents inside bulky tissue, since combined monitoring these two parameters provides potential means vivo interrogating quantitative environmental information specific molecules, as well accessing interactions among them. It is widely accepted that an advantageous way accomplishing the task context small-animal to use time-domain (TD) modality. In this...
Purpose: Noise characterization through estimation of the noise power spectrum (NPS) is a central component evaluation digital x‐ray systems. Extensive works have been conducted to achieve accurate and precise measurement NPS. One approach improve accuracy NPS reduce statistical variance results by involving more data samples. However, this method based on assumption that in radiographic image arising from stochastic processes. In practical data, artifactuals always superimpose as...
We present in vivo images of near-infrared (NIR) diffuse optical tomography (DOT) human lower legs and forearm to validate the dual functions a time-resolved (TR) NIR DOT clinical diagnosis, i.e., provide anatomical functional information simultaneously. The system is composed time-correlated single-photon-counting channels, image reconstruction algorithm based on modified generalized pulsed spectral technique, which effectively incorporates TR data with reasonable computation time....
A full time-resolved scheme that has been previously applied in diffuse optical tomography is extended to time-domain fluorescence regime, based on a finite-element-finite-time-difference photon diffusion modeling and Newton-Raphson inversion framework. The merits of using data are twofold: it helps evaluate the intrinsic performance mode for improvement image quality set up valuable reference assessment computationally efficient featured-data-based algorithms, provides self-normalized...
Objective: The purpose of this study was to develop a phantom-based experimental calibration method minimize the reconstruction artifacts for geometric misalignments digital tomosynthesis prototype. Methods: A phantom with ten fiducial markers designed. Using phantom, projection matrices an prototype were acquired from each view under series misalignment conditions. American College Radiology mammography imaged and reconstructed without using correction corresponding matrices. effectiveness...
We implemented a novel lock-in photon-counting detection architecture that combines the ultra-high sensitivity of and measurement parallelism technique.Based on this technique, dual-wavelength simultaneous continuous wave diffuse optical tomography system was developed with configuration 16 sources detectors works in tandem serialto-parallel fashion.Methodology validation performance assessment were conducted using phantom experiments demonstrate excellent linearity, moderate-term stability,...
As a visualizing and quantitative method, Fluorescence Molecular Tomography (FMT) has many potential applications in biomedical field its three-dimensional (3D) implementation is needed both theory practice. In this paper, we propose 3D scheme for time-domain FMT within the normalized Born-ratio formulation. A finite element method solution to Laplace transformed coupled diffusion equations employed as forward model, resultant linear inversions at two distinct transform-factors are solved...
One of the primary applications diffuse optical imaging is to localize and quantify changes in cerebral oxygenation during functional brain activation. Up now, data from an imager are simply presented as a two-dimensional (2D) topographic map using modified Beer–Lambert law that assumes homogeneous properties beneath each optode. Due highly heterogeneous nature brain, assumption evidently invalid, leading both low spatial resolution inaccurate quantification assessment haemodynamic changes....
Although a foil three-dimensional (3-D) reconstruction with both 3-D forward and inverse models provide, the optimal solution for diffuse optical tomography (DOT), because of nature photon diffusion in tissue, it is computationally costly memory requirement execution time conventional computing environment. Thus practice there motivation to develop an image algorithm dimensional reduction based on some modeling approximations. Here we have implemented semi-3-D modified generalized pulse...
The modulation transfer function (MTF) of radiographic systems is frequently evaluated by the system's line spread (LSF) using narrow slits. conventional slit method requires LSF tail approximation, which achieved exponentially extrapolating tails beyond 1% peak value. However, estimated MTF at low frequencies from extrapolation may not reflect true performance system. In this study, a monotone spline regression technique for approximation developed to improve accuracy estimation...
A combined time-domain fluorescence and hemoglobin diffuse optical tomography (DOT) system the image reconstruction methods are proposed for enhancing reliability of breast-dedicated measurement.The equipped with two pulsed laser diodes at wavelengths 780 nm 830 that specific to peak excitation emission FDA-approved ICG agent, works a 4-channel time-correlated single photon counting device acquire time-resolved distributions light re-emissions 32 boundary sites tissues in tandem...
In this article, we briefly described a time-correlated single photon counting (TCSPC) system specifically designed for extracting the optical properties in turbid medium. This was evaluated by use of two sets liquid tissue-simulating phantoms containing different concentrations Intralipid-10% as scatters and India ink absorbers. With distribution times flight (DTOF) photons measured TCSPC system, some featured parameters, such mean time variance DTOF were calculated. Based on these...
Hybrid imaging methods combining diffuse optical tomography (DOT) and other anatomical or nonoptical functional modalities have been widely investigated to improve performance degraded by the strong scattering of biological tissues, through constraining reconstruction process prior structures. However, these with different contrast mechanisms may be ineffective in revealing early-staged lesions high but no morphological changes. Photoacoustic (PAT) is particularly useful for visualizing...
Spatial frequency domain (SFD) measurement allows rapid and non-contact wide-field imaging of the tissue optical properties, thus has become a potential tool for assessing physiological parameters therapeutic responses during photodynamic therapy skin diseases. The conventional SFD requires reference within same experimental scenario as that test one to calibrate mismatch between real measurements model predictions. Due individual physical geometrical differences among different tissues,...