A5100369067- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Photosynthetic Processes and Mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Immune cells in cancer
- Force Microscopy Techniques and Applications
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Mitochondrial Function and Pathology
- Retinal Imaging and Analysis
- Pluripotent Stem Cells Research
- Magnetic Properties and Applications
- Cancer Immunotherapy and Biomarkers
- Plant Molecular Biology Research
- Magnetic properties of thin films
- Plant Gene Expression Analysis
- DNA Repair Mechanisms
- Chemokine receptors and signaling
- Retinal and Optic Conditions
- Muscle and Compartmental Disorders
- Veterinary medicine and infectious diseases
- Metalloenzymes and iron-sulfur proteins
- Retinal Diseases and Treatments
- Renal Transplantation Outcomes and Treatments
Guangxi University
2025
Guangxi University of Chinese Medicine
2025
Nankai University
2011-2025
Tianjin University
2023-2025
Tianjin Medical University
2023-2025
Xiangya Hospital Central South University
2024
Central South University
2024
Communication University of China
2024
Guangdong Medical College
2024
Huazhong University of Science and Technology
2024
Diabetic Retinopathy (DR) grading is challenging due to the presence of intra-class variations, small lesions and imbalanced data distributions. The key for solving fine-grained DR find more discriminative features corresponding subtle visual differences, such as microaneurysms, hemorrhages soft exudates. However, are quite difficult identify using traditional convolutional neural networks (CNNs), an distribution will cause model pay too much attention grades with samples, greatly affecting...
Abstract Breast cancer (BC) is a multifaceted disease characterized by distinct molecular subtypes and varying responses to treatment. In BC, the phosphatidylinositol 3-kinase (PI3K) pathway has emerged as crucial contributor development, advancement, resistance This review article explores implications of PI3K in predictive, preventive, personalized medicine for BC. It emphasizes identification predictive biomarkers, such PIK3CA mutations, utility profiling guiding treatment decisions. The...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPsaD is required for the stable binding of PsaC to photosystem I core protein Synechococcus sp. PCC 6301Ning Li, Jindong Zhao, Patrick V. Warren, Joseph T. Warden, Donald A. Bryant, and John H. GolbeckCite this: Biochemistry 1991, 30, 31, 7863–7872Publication Date (Print):August 1, 1991Publication History Published online1 May 2002Published inissue 1 August...
Cyanobacterial aldehyde decarbonylases (ADs) catalyze the conversion of C(n) fatty aldehydes to formate (HCO(2)(-)) and corresponding C(n-1) alk(a/e)nes. Previous studies Nostoc punctiforme (Np) AD produced in Escherichia coli (Ec) showed that this apparently hydrolytic reaction is actually a cryptically redox oxygenation process, which one O-atom incorporated from O(2) into protein-based reducing system (NADPH, ferredoxin, ferredoxin reductase; N/F/FR) provides all four electrons needed for...
Stress and its related hormones epinephrine (E) norepinephrine (NE) play a crucial role in tumor progression. Macrophages the microenvironment (TME) polarized to M2 is also vital pathway for deterioration. Here, we explore underlying of macrophages effect stress E promoting breast cancer growth. It was found that weight volume bearing mice were increased, dramatically accompanied with rising level after chronic using social isolation. What most noteworthy, number inside up-regulated it. The...
Considerable evidence suggests that the heterogeneity of ovarian cancer (OC) is a major cause treatment failure. Single-cell RNA sequencing (scRNA-seq) powerful tool to analyse tumour at single-cell level, leading better understanding cell function genetic and cellular levels.OC scRNA-seq data were extracted from Gene Expression Omnibus (GEO) database FindCluster () package used for cluster analysis. The GSVA was single-sample gene set enrichment analysis (ssGSEA) obtain Hallmark score bulk...
Summary Chloroplast development requires coordinated expression of both nuclear‐ and chloroplast‐encoded genes. To better understand the roles played by nuclear‐encoded chloroplast proteins in biogenesis, we isolated an Arabidopsis mutant, egy1 ‐ 1 , which has a dual phenotype, reduced chlorophyll accumulation abnormal hypocotyl gravicurvature. Subsequent map‐based cloning DNA sequencing mutant gene revealed 10‐bp deletion EGY1 gene, encodes 59‐kDa metalloprotease that contains eight trans...
PTEN has been studied in several tumor models as a suppressor. In this study, we explored the role of inhibition state polarized M2 subtype macrophage microenvironment (TME) and underlying mechanisms. To elucidate potential effect TME, RAW 264.7 macrophages 4T1 mouse breast cancer cells were co-cultured to reconstruct microenvironment. After was down-regulated with shRNA, expression CCL2 VEGF-A, which are definited promote formation macrophages, have dramatically increase on level both gene...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSite-directed conversion of a cysteine to aspartate leads the assembly N iron-sulfur[3Fe-4S] cluster PsaC photosystem I. The photoreduction FA is independent FBJindong Zhao, Ning Li, Patrick V. Warren, John H. Golbeck, and Donald A. BryantCite this: Biochemistry 1992, 31, 22, 5093–5099Publication Date (Print):June 9, 1992Publication History Published online1 May 2002Published inissue 9 June 1992https://doi.org/10.1021/bi00137a001RIGHTS &...
Increasing evidence suggests tumor-associated macrophages (TAMs) are polarized M2 subtype of macrophage that exerts pro-tumor effects and promote the malignancy some cancers, but concrete mechanism is not well defined. Our previous research exhibited proto-oncogene AP-1 regulated IL-6 expression in promoted formation macrophages. In this study, we investigate whether extra-cellular stimulus M-CSF help process or nuclear factor NFκB has a synergistic role activation state macrophage. RAW...
A highly enantioselective intramolecular Rauhut-Currier reaction catalyzed by a multifunctional chiral aminophosphine catalyst was reported. series of hydro-2H-indole derivatives that bear an all-carbon quaternary center were obtained in high yields (up to 94%), and excellent diastereo- enantioselectivities >20 : 1 dr >99% ee). And this could be performed on gram scale using 2 mol% loading.
Abstract Enrichment of regulatory T cells (Tregs) in the tumour microenvironment (TME) has been recognized as one major factors initiation and development resistance to immune checkpoint inhibitors. C–C motif chemokine receptor 8 (CCR8), a marker activated suppressive Tregs, significant impact on functions Tregs TME. However, mechanism CCR8 remains unclear. Here, we reveal that high level TNF-α colorectal cancer (CRC) upregulates expression via TNFR2/NF-κB signalling pathway FOXP3...
A fusion protein, denoted PsaCl, which contains an amino‐terminal extension of five amino acids (MEHSM...) and is derived from in vitro modified form the psaC gene Synechococcus sp. PCC 7002, has been over‐expressed Escherichia coli . The product psaD Nostoc 8009 similarly over‐expressed. PsaCl PsaD proteins can be combined with photosystem I core protein 6301 to reconstitute electron transport P700 terminal F /F B acceptors. Reconstitution was found absolutely dependent on reinsertion...
Cyclin-dependent kinase 5 (Cdk5) and its activator p35 are critical for radial migration lamination of cortical neurons. However, how this is regulated by extracellular intracellular signals during morphogenesis remains unclear. Here, we show that PKCdelta, a member novel PKC expressing in neurons, could stabilize direct phosphorylation. PKCdelta attenuated the degradation but not mutant derivative, which be phosphorylated PKCdelta. Down-regulation utero electroporation specific small...
Abstract Presented herein is the first direct alkylation and hydroxylation reaction between two different C(sp 3 )−H bonds, indolin‐2‐ones alkyl‐substituted N‐heteroarenes, through an oxidative cross‐coupling reaction. The catalyzed by a simple iron salt under mild ligand‐free base‐free conditions. environmentally benign, employs air (molecular oxygen) as terminal oxidant oxygen source for synthesis of O‐containing compounds, produces only water byproduct.