A5072586021- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Asymmetric Synthesis and Catalysis
- Sulfur-Based Synthesis Techniques
- Crystallography and molecular interactions
- Asymmetric Hydrogenation and Catalysis
- Advanced Synthetic Organic Chemistry
- Cyclopropane Reaction Mechanisms
- Synthesis and Catalytic Reactions
- Radical Photochemical Reactions
- Phosphorus compounds and reactions
- Analytical Chemistry and Chromatography
- Metabolomics and Mass Spectrometry Studies
- Synthesis and Biological Activity
- Catalytic Alkyne Reactions
- Axial and Atropisomeric Chirality Synthesis
- Mass Spectrometry Techniques and Applications
- Synthesis and Characterization of Pyrroles
- Fullerene Chemistry and Applications
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Chemical synthesis and alkaloids
- Synthesis and Properties of Aromatic Compounds
Tianjin University of Traditional Chinese Medicine
2020-2024
National University of Singapore
2020
Nankai University
2014-2019
Henan Normal University
2014
The application of photocatalyzed Minisci-type reactions in LSF accelerates the discovery drug candidates a green way.
Abstract A highly stereoselective sequential annulation reaction between γ‐substituted allenoates and ketimines was reported. By using bifunctional N ‐acyl aminophosphine catalysts, poly‐heterocycle rings were obtained with high stereocontrol in good to excellent yields. The desired products have four contiguous stereogenic centers (one quaternary three tertiary carbon centers), only one isomer all reactions.
A novel phosphine-catalyzed sequential [2 + 3] and [3 2] annulation domino reaction of γ-benzyl-substituted allenoates has been developed. The can proceed smoothly to produce the corresponding aza-bicyclo[3,3,0]octane derivatives in good yields excellent diastereoselectivity (only one isomer).
Divergent domino annulation reactions of sulfur ylides and azadienes were developed. A wide range functionalized benzofuran-fused six- seven-membered nitrogen–heterocyclic compounds prepared in moderate to excellent yields under mild conditions. It is worth noting that the crotonate-derived could be used as a novel C2 synthon or C3 selectively by simply transforming base.
An unprecedented [3 + 2]-annulation of prop-2-ynylsulfonium salts and p-quinamines was developed, affording a series hydroindol-5-ones with methylthio group in moderate to good yields under mild conditions. In this reaction, the salt acts as novel C2 synthon sulfide does not serve leaving group, which provides facile access organosulfur compouds.
A convenient and efficient Cu(OAc)2-mediated N-heteroannulation reaction of [60]fullerene with N-sulfonylated o-amino-aromatic methyl ketones or O-alkyl oximes has been reported for the synthesis novel scarce [60]fullerene-fused tetrahydroazepinones -azepinonimines in a highly selective manner. Moreover, possible mechanism involving two pathways is proposed on basis experimental observations.
A highly enantioselective intramolecular Rauhut-Currier reaction catalyzed by a multifunctional chiral aminophosphine catalyst was reported. series of hydro-2H-indole derivatives that bear an all-carbon quaternary center were obtained in high yields (up to 94%), and excellent diastereo- enantioselectivities >20 : 1 dr >99% ee). And this could be performed on gram scale using 2 mol% loading.
A sequential annulation domino reaction of sulfur ylides and α,β-unsaturated cyclic ketimines for the construction 2-alkenyl aziridines has been developed. Readily accessible starting materials, a one-pot procedure, excellent functional group compatibility, mild conditions make this transformation powerful tool synthesis aziridines.
The first enantioselective sequential phosphine-catalyzed (SPC as abbreviation) mode for the formation of tetrahydroquinolines with an ethynyl-substituted all-carbon quaternary stereogenic center is reported. In this SPC process, a novel [4 + 2] annulation process was devised employing α-substituted allenoates C2 synthons (α–β′, 1,2-dipole) time. 3-Ethynyl-substituted were readily prepared in good yields and high enantioselectivities.
A powerful sequential [1 + 4]- and [2 3]-annulation has been developed using prop-2-ynylsulfonium salts sulfonyl-protected o-amino aromatic aldimines, affording a series of hexahydropyrrolo[3,2-b]indoles in high yields. Prop-2-ynylsulfonium act as C2 synthons the reaction, fused rings containing two five-membered azaheterocycles can be constructed single operation with readily accessible starting materials.
Organosulfur compounds, especially sulfur ylides and sulfonium salts, offer extraordinary potential in organic chemistry due to their distinctive structural properties reactivities. In the past five years, tremendous progress of...
Abstract The first sulfur ylides involved formal [5+1]‐annulation reaction was developed between prop‐2‐ynylsulfonium salts and 2‐(1 H ‐indol‐2‐yl)phenols. Prop‐2‐ynylsulfonium salt participates in the with its β‐carbon atom acts as a novel C 1 synthon. Various indole‐fused 4 ‐benzo[ e ][1,3]oxazines bearing thioether moiety were constructed good to high yields under mild conditions. magnified image
Abstract A formal sequential [1+2]‐ and [2+3]‐annulation of prop‐2‐ynylsulfonium salts tosylaminomethyl enones was developed, constructing a series methylene azabicyclo[3.1.0]hexane derivatives. one‐pot procedure established via hydration an enamine intermediate to afford substituted cyclopropanes. Prop‐2‐ynylsulfonium acted as both C 2 1 synthons in these two processes. magnified image
Abstract A highly stereoselective sequential annulation reaction between γ‐substituted allenoates and ketimines was reported. By using bifunctional N ‐acyl aminophosphine catalysts, poly‐heterocycle rings were obtained with high stereocontrol in good to excellent yields. The desired products have four contiguous stereogenic centers (one quaternary three tertiary carbon centers), only one isomer all reactions.
A new phosphine-catalyzed sequential [3+3]/[3+3] annulation of δ-sulfonamido-allenoates and dienes for hydroisoquinoline derivatives with excellent yields wide substrate scope.
Herein, we disclose a facile photoinduced difunctionalization of alkenes, enabling the synthesis valuable β-amino alcohols, ethers, and 1,2-diamines with diverse nucleophiles. The protocol relies on use readily accessible dibenzothiophene-based sulfilimines as novel
Abstract A highly stereoselective sequential annulation reaction between γ‐substituted allenoates and ketimines is reported.