Lin Zhang

ORCID: 0000-0003-3064-7975
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About
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Research Areas
  • Risk and Safety Analysis
  • Inflammatory Biomarkers in Disease Prognosis
  • Meta-analysis and systematic reviews
  • Dialysis and Renal Disease Management
  • Metabolomics and Mass Spectrometry Studies
  • Gut microbiota and health
  • Signaling Pathways in Disease
  • Pharmacological Effects of Natural Compounds
  • Inflammatory Bowel Disease
  • Health Systems, Economic Evaluations, Quality of Life
  • Tryptophan and brain disorders
  • Ginseng Biological Effects and Applications
  • Statistical Methods in Clinical Trials
  • Cardiac Fibrosis and Remodeling
  • Acute Myocardial Infarction Research
  • Occupational Health and Safety Research
  • Mycobacterium research and diagnosis
  • Topology Optimization in Engineering
  • Erythropoietin and Anemia Treatment
  • Iron Metabolism and Disorders
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Pharmacological Effects of Medicinal Plants
  • Blood properties and coagulation
  • RNA modifications and cancer
  • Drug-Induced Hepatotoxicity and Protection

Yuhuangding Hospital
2025

Qingdao University
2025

Tianjin University of Traditional Chinese Medicine
2021-2023

Civil Aviation Administration of China
2021

Civil Aviation University of China
2021

North Minzu University
2017

Dalian Ocean University
2013

North China University of Science and Technology
2011

Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease with an increasing incidence and prevalence worldwide. The diagnosis for UC mainly relies on clinical symptoms laboratory examinations. As some previous studies have revealed that there association between gene expression signature severity, we thereby aim to assess whether genes can help diagnose predict its correlation immune regulation. A total of ten eligible microarrays (including 387 patients 139 healthy...

10.1038/s41598-022-14048-6 article EN cc-by Scientific Reports 2022-06-15

Abstract Background Acute myocardial infarction (AMI) has two clinical characteristics: high missed diagnosis and dysfunction of leukocytes. Transcriptional RNA on leukocytes is closely related to the course evolution AMI patients. We hypothesized that transcriptional in might provide potential diagnostic value for AMI. Integration machine learning (IML) was first used explore discrimination genes. The following study performed validate results. Methods A total four microarrays (derived from...

10.1186/s12967-023-04573-x article EN cc-by Journal of Translational Medicine 2023-10-27

Cognitive dysfunction is a critical complication of diabetes mellitus, and there are still no clinically approved drugs. Zi Shen Wan Fang (ZSWF) an optimized prescription composed Anemarrhenae Rhizoma, Phellodendri Chinensis Cortex, Cistanches Herba. The purpose this study to investigate the effect ZSWF on DCI explore its mechanism from perspective maintaining intestinal microbial homeostasis in order find effective for treating DCI.

10.3389/fphar.2022.898360 article EN cc-by Frontiers in Pharmacology 2022-07-15

Drug-induced liver injury (DILI) is the most common adverse effect of numerous drugs and a leading cause drug withdrawal from market. In recent years, incidence DILI has increased. However, diagnosing remains challenging because lack specific biomarkers. Hence, we used machine learning (ML) to mine multiple microarrays identify useful genes that could contribute DILI. this prospective study, screened six eligible Gene Expression Omnibus (GEO) database. First, 21 differentially expressed...

10.3390/ijms231911945 article EN International Journal of Molecular Sciences 2022-10-08

achieved on Hazmat transportation routing problems in order to minimize risk-related costs which is consequence of a natural accident. As the terrorist threat growing, shipment has became new target attacks, it therefore necessary consider into model. In this work, we following hazmat scheduling problem traffic engineering: be shipped over road network transport given amount hazardous materials from specific origin point destination every day. We design route risks accident and uncertainty...

10.1016/j.sepro.2011.08.022 article EN cc-by-nc-nd Systems Engineering Procedia 2011-01-01

To assess the reporting quality of randomized controlled trials (RCTs) with multicenter design, particularly whether necessary information related to characteristics was adequately reported.Through a search 4 international electronic databases, we identified RCTs published in English from 1975 2019. Reporting assessed by CONSORT (Consolidated Standards Trials) checklist (37 items) and self-designed multicenter-specific (27 items covering implement analysis). The scores three time periods...

10.1016/j.jclinepi.2021.05.008 article EN cc-by-nc-nd Journal of Clinical Epidemiology 2021-05-21

Machine learning (ML) has gained intensive popularity in various fields, such as disease diagnosis healthcare. However, it limitation for single algorithm to explore the diagnosing value of dilated cardiomyopathy (DCM). We aim develop a novel overall normalized sum weight multiple-model MLs assess DCM.Gene expression data were selected from previously published databases (six sets eligible microarrays, 386 samples) with criteria. Two microarrays used training; others studied testing (ratio...

10.3389/fcvm.2022.1044443 article EN cc-by Frontiers in Cardiovascular Medicine 2023-01-11

Abstract Objective To assess the reporting quality of randomised controlled trials (RCTs) massage, particularly whether necessary elements related to massage interventions were adequately reported. Methods A total 8 electronic databases systematically searched for RCTs published in English and Chinese from date their inception June 22, 2020. Quality assessment was performed using three instruments, namely CONSORT (Consolidated Standards Reporting Trials) 2010 Checklist (37 items), Extension...

10.1186/s13020-021-00475-6 article EN cc-by Chinese Medicine 2021-07-28

Aims Red blood cell distribution width/albumin ratio (RAR) is a novel parameter associated with inflammation. Previous studies have not focused on the role of RAR in incidence and long-term prognosis chronic heart failure (CHF). This study included three cohorts, two prospective one retrospective study. The aim was to investigate value CHF CHF. Methods Three cohorts were investigated, including MIMIC, NHANES, JHDH. patients JHDH 22,672 from 2001-2012, 60,754 1999-2020, 15,102 2021-2022,...

10.1101/2023.09.07.23295180 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2023-09-08

This paper considers an uncertain variational inequality problem (UVIP).We first establish UVIP as optimization (ERM model) which minimizes the expected residual of so-called regularized gap function.Then, we make some assumptions about a subclass in function involved is affine.Thus priority our to discuss properties ERM and comprehensive convergence analysis under uncertainty theory.In end, conclusion.

10.22436/jnsa.010.11.33 article EN The Journal of Nonlinear Sciences and Applications 2017-11-24

In this paper, to explore the risk identification, source term analysis, consequences calculations, assessment, management of petrochemical project, a case analysis was conducted, which is company planned 900,000 tons / year gasoline refining unit construction project. The results showed that project spill will not spread outside environment, explosion cause part plant severelydamaged, but accident value lower, maximum credible on environment could be caused by less risk. Risk level acceptable.

10.4028/www.scientific.net/amr.726-731.1101 article EN Advanced materials research 2013-08-01

The development of the civil aviation industry has continuously increased requirements for efficiency airport ground support services. In existing research, there not yet been a process model that directly obtains from log to study causal relationship between service nodes and flight delays. Most studies mainly use machine learning methods predict delays, they are based on is an ideal model. did conduct in-depth mechanism behind link reveal true cause Therefore, certain deviation in...

10.1155/2021/2869521 article EN cc-by Journal of Advanced Transportation 2021-09-17

Background Hypertensive patients are always accompanied by erythrocyte dysfunction. However, current erythrocyte-related indicators can’t explain hypertension’s prevalence and long-term prognosis. Therefore, hemoglobin specific volume width (HSW) was first created to this phenomenon. Methods 59,867 adult participants from National Health Nutrition Examination Survey (NMAHES) were included. HSW’s quartiles determined with Q1 [1.88,3.64] cL/g, Q2 (3.64,3.84] Q3 (3.84,4.11] Q4 (4.11,11.74]...

10.1101/2023.08.15.23294146 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2023-08-16

Abstract Background: Hypertensive patients are always accompanied by erythrocyte dysfunction. However, current erythrocyte-related indicators can’t explain hypertension's prevalence and long-term prognosis. Therefore, hemoglobin specific volume width (HSW) was first created to this phenomenon. Methods: 59,867 adult participants from National Health Nutrition Examination Survey (NMAHES) were included. HSW’s quartiles determined with Q1 [1.88,3.64] cL/g, Q2 (3.64,3.84] cL/g , Q3 (3.84,4.11] Q4...

10.21203/rs.3.rs-3273756/v1 preprint EN cc-by Research Square (Research Square) 2023-08-23

Abstract To perform a bibliometric visualization in lipidomics-related research with two decades. The primary data was retrieved from the Web of Science, three sotwares (VOSviewer, CiteSpace, and R) provided an overview this field. countries, institutions, authors, key terms, keywords were tracked corresponding mapping generated. From January 1st 2001 to March 21th 2022, 45,325 authors 234 organizations 101 countries published 7,338 publications 382 journals found. Journal Lipid Research...

10.1101/2023.09.07.23295179 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2023-09-07

Abstract Background Acute myocardial infarction (AMI) has two clinical characteristics: high missed diagnosis and dysfunction of leukocytes. Transcriptional RNA on leukocytes is closely related to the course evolution AMI patients. We hypothesized that transcriptional in might provide potential diagnostic value for AMI. Integration machine learning (IML) was first used explore discrimination genes. The following study performed validate results. Methods A total four microarrays (derived from...

10.1101/2023.09.07.23295181 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2023-09-08
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