A5101595504- Analytical chemistry methods development
- Pharmaceutical and Antibiotic Environmental Impacts
- Gut microbiota and health
- Synthesis and Characterization of Heterocyclic Compounds
- RNA modifications and cancer
- Ginseng Biological Effects and Applications
- Quinazolinone synthesis and applications
- Diabetes Treatment and Management
- Lung Cancer Research Studies
- Microbial Community Ecology and Physiology
- Cancer therapeutics and mechanisms
- Cancer Mechanisms and Therapy
- Metabolomics and Mass Spectrometry Studies
- Oral health in cancer treatment
- Health, Environment, Cognitive Aging
- Synthesis and biological activity
- Mycobacterium research and diagnosis
- CO2 Reduction Techniques and Catalysts
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Phytochemistry and Bioactive Compounds
- Synthesis and Biological Evaluation
- Inflammasome and immune disorders
- Bioactive Compounds and Antitumor Agents
- Gestational Trophoblastic Disease Studies
Ministry of Agriculture and Rural Affairs
2024
Nanjing Agricultural University
2024
Gansu University of Traditional Chinese Medicine
2023
Guangxi University of Chinese Medicine
2013-2023
Tianjin University of Traditional Chinese Medicine
2023
Jiangnan University
2019-2022
Southeast University
2022
State Key Laboratory of Digital Medical Engineering
2022
Jiangxi University of Traditional Chinese Medicine
2022
Soochow University
2018-2021
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) selectively targets cancer cells. The present preclinical study investigated the anti-cancer efficiency of ONC201, a first-in-class small molecule TRAIL inducer, in lung We showed that ONC201 was cytotoxic and anti-proliferative both established (A549 H460 lines) primary human It yet non-cytotoxic to normal epithelial Further, induced exogenous apoptosis activation cells, which evidenced by TRAIL/death receptor-5 (DR5)...
Ribosomal protein S14 (RPS14) is a component of the 40S ribosomal subunit and considered to be indispensable for biogenesis. Previously, we found that RPS14 was significantly downregulated in estrogen receptor-positive (ER+) breast cancer cells following treatment with 4-hydroxytamoxifen (4-OH-TAM). However, its role remains poorly understood. In present study, sought demonstrate, first time, highly expressed ER+ tissues downregulation can inhibit proliferation, cycle, metastasis cells, as...
Male primary choriocarcinoma is a rare and invasive malignant neoplasm for which traditional chemotherapy has limited efficacy. Pembrolizumab humanized monoclonal anti-programmed death-1 antibody that antitumor activity in numerous malignancies. The diagnosis treatment of two cases advanced male were retrospectively analyzed relevant literature was reviewed to discuss the prognosis efficacy different treatments, including pembrolizumab. first patient, who presented with cough hemoptysis,...
Aim. We sought to profile gut microbiota’s role in combination of Bu Fei Hua Yu (BFHY) with cisplatin treatment. Methods. Non-small cell lung cancer (NSCLC) mice model were constructed followed by treatment alone or combined BFHY. Mice weight and tumor volume measured during the experiment. And cecum detected hematoxylin eosin, contents collected for Enzyme Linked ImmuneSorbent Assay, stool profiled metagenomic sequencing. Results. Combination BFHY decreased growth relieved damage cecum....
Abstract G protein‐coupled receptor 119 (GPR119) is a member of the GPCR family promising to be target for type 2 diabetes mellitus (T2DM) treatment. In this work, 30 novel compounds were designed, synthesized, and evaluated by in vitro cAMP activation assay, where II–14 II–18 showed best potency with EC 50 values 69 99 nM, respectively. oral glucose tolerance test, compound even more efficacious activity lowering blood excursions than MBX‐2982 at fixed dose mg/kg. Here, we report that its...
IntroductionBufei Huayu Decoction (BFHY) is a clinical prescription with reported efficacy in enhancing the therapeutic outcomes of chemotherapeutic agents for non-small cell lung cancer (NSCLC). However, underlying metabolic mechanism BFHY's action remains unexplored.ObjectiveThe objective this study to investigate global effects cisplatin and plus BFHY on NSCLC.MethodsThree groups (NSCLC, cisplatin, + BFHY) underwent serum metabolomics procedure based UHPLC-QE-MS. Then, pathway analysis...
Abstract To perform a bibliometric visualization in lipidomics-related research with two decades. The primary data was retrieved from the Web of Science, three sotwares (VOSviewer, CiteSpace, and R) provided an overview this field. countries, institutions, authors, key terms, keywords were tracked corresponding mapping generated. From January 1st 2001 to March 21th 2022, 45,325 authors 234 organizations 101 countries published 7,338 publications 382 journals found. Journal Lipid Research...