A5101664589- Phytochemistry and Bioactive Compounds
- Bioactive Compounds and Antitumor Agents
- Cancer therapeutics and mechanisms
- Ginseng Biological Effects and Applications
- Mycobacterium research and diagnosis
- Gut microbiota and health
Guangxi University of Chinese Medicine
2023
Aim. We sought to profile gut microbiota’s role in combination of Bu Fei Hua Yu (BFHY) with cisplatin treatment. Methods. Non-small cell lung cancer (NSCLC) mice model were constructed followed by treatment alone or combined BFHY. Mice weight and tumor volume measured during the experiment. And cecum detected hematoxylin eosin, contents collected for Enzyme Linked ImmuneSorbent Assay, stool profiled metagenomic sequencing. Results. Combination BFHY decreased growth relieved damage cecum....
IntroductionBufei Huayu Decoction (BFHY) is a clinical prescription with reported efficacy in enhancing the therapeutic outcomes of chemotherapeutic agents for non-small cell lung cancer (NSCLC). However, underlying metabolic mechanism BFHY's action remains unexplored.ObjectiveThe objective this study to investigate global effects cisplatin and plus BFHY on NSCLC.MethodsThree groups (NSCLC, cisplatin, + BFHY) underwent serum metabolomics procedure based UHPLC-QE-MS. Then, pathway analysis...