A5100747531- Computational Drug Discovery Methods
- Autophagy in Disease and Therapy
- Osteoarthritis Treatment and Mechanisms
- Pharmacological Effects of Natural Compounds
- SARS-CoV-2 and COVID-19 Research
- Inflammatory mediators and NSAID effects
- Neurological Disease Mechanisms and Treatments
- Anesthesia and Pain Management
- Acupuncture Treatment Research Studies
- Heart Rate Variability and Autonomic Control
- Mitochondrial Function and Pathology
- Vestibular and auditory disorders
- Peroxisome Proliferator-Activated Receptors
- Respiratory Support and Mechanisms
- Earthquake and Tsunami Effects
- Xenotransplantation and immune response
- Andrographolide Research and Applications
- Cerebral Venous Sinus Thrombosis
- Cardiac Health and Mental Health
- Cell Adhesion Molecules Research
- Nausea and vomiting management
- Management of metastatic bone disease
- Gout, Hyperuricemia, Uric Acid
- Heme Oxygenase-1 and Carbon Monoxide
- COVID-19 Clinical Research Studies
Shanghai University of Traditional Chinese Medicine
2023-2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2024-2025
Osaka University
2024
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2010-2021
Heilongjiang University of Chinese Medicine
2021
Xinjiang Medical University
2008-2020
Cangzhou Central Hospital
2020
Technical University of Denmark
2020
Heilongjiang University
2004-2019
Chenzhou First People's Hospital
2019
<h3>Importance</h3> Thyroid cancer is the most pervasive endocrine worldwide. Studies examining association between thyroid and country, sex, age, sociodemographic index (SDI), other factors are lacking. <h3>Objective</h3> To examine burden variation trends at global, regional, national levels using data on SDI. <h3>Design, Setting, Participants</h3> In this cross-sectional study, epidemiologic were gathered Global Health Data Exchange query tool, covering persons of all ages with in 195...
Curcumin has shown protective potential on osteoarthritis. However, its effect treatment of osteoarthritis remains elusive so far. This study aimed to determine whether curcumin could ameliorate in vivo and the underline mechanisms. The mice subjected destabilization medial meniscus (DMM) surgery were administered curcumin. Cartilage integrity was evaluated by immunohistological staining. Expression levels inflammatory cytokines from arthrodial cartilage detected. THP-1 cells primed...
Abstract Background Acupuncture treatment possesses the neuroprotection potential to attenuate cerebral ischemia–reperfusion (I/R) injury. Endoplasmic reticulum (ER) stress has been suggested be involved in pathogenic mechanism of I/R Whether acupuncture protects against injury via regulating ER remains unclear. This study aimed evaluate role and its underlying mechanisms. Methods Cerebral was induced by middle artery occlusion (MCAO) rats. carried out at Baihui (GV 20), Qubin (GB7)...
The ongoing emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has led to resistance against multiple disease 2019 (COVID-19) vaccines and therapeutic medications, making the development effective therapeutics SARS-CoV-2 a high priority. Studies have shown that bioactive polyphenols, particularly those with triphenol groups, can effectively inhibit activity 3-chymotrypsin-like protease (3CLpro). However, structural instability polyphenols necessitates further...
Interleukin (IL)-37 has been described as a negative regulator of immune responses and is critical for asthma pathogenesis, but the mechanisms behind protective role IL-37 against allergic are less well understood. We show here that administered intranasally inhibited house dust mite (HDM)-induced chronic airway eosinophilic inflammation, goblet cell hyperplasia, peribronchial collagen deposition hyperresponsiveness (AHR) to methacholine. In contrast weakened Th2 response in lung was...
This study was conducted to compare the therapeutic effect and complications of laparoscopic radical gastrectomy (LRG) with those traditional open surgery in elderly patients gastric cancer (GC). We a retrospective comparison efficacy between GC (defined as aged ≥70 years) who received underwent by surgery. A total 108 either (n=54) or at General Hospital Lanzhou Military Region June, 2008 March, 2009 were analyzed. Compared surgery, LRG exhibited several advantages, such being less...
Danshensu extracted with traditional Chinese medicine Salvia miltiorrhiza has a wide range of bioactivities. containing catechol moiety moderate inhibitory effect on SARS-CoV-2 3CLpro (IC50 = 2.2 μM) by reversible covalent interaction and exhibits good anti-inflammatory activity. To enhance the activity, we introduced Michael receptors into side chain danshensu as possible warhead blocked binding sites to yield chalcone derivatives. The resulting derivatives, A4 A7, were found inhibit in...
Background: Osteoarthritis (OA) is a chronic joint-degeneration disease and accounts for the most frequent arthritis in aging people. OA characterized by degeneration of articular cartilage, subchondral bone sclerosis synovitis. Inflammation as an important role progression, that anti-inflammatory agents could effectively inhibit development with minimal side effects, therefore developing nature compound will be promising therapy treating OA. Methods: We treated patient-derived chondrocytes...
A rhodium( ii )-catalyzed reaction of 3-hydroxyisoindolinones and diazos via an intermolecular OH transfer to deliver isoindolinone derivatives containing continuous quaternary carbons as products is developed in high yields up 89%.
Abstract Arctic offshore structures are subject to combined wave-ice actions. However, the underlying mechanisms governing interaction between waves ice and these remain inadequately understood. Performing well-controlled laboratory experiments is a fundamental approach acquiring insights into such complicated physical processes. This paper builds on analyzing data that were obtained from HYDRALAB+ Transnational Access project: Loads Structure Waves in Ice (LS-WICE), studies inline wave...
Although the coronavirus disease 2019 (COVID-19) crisis has passed, there remains a necessity for continuous efforts toward developing more targeted drugs and preparing potential future virus attacks. Currently, most of received authorization treatment COVID-19 have exhibited several limitations, such as poor metabolic stability, formidable preparation, uncertain effectiveness. It is still significant to develop novel, structurally diverse small-molecule antiviral targeting SARS-CoV-2...
Chondrocytes in injured cartilage tissue are susceptible to mechanical loading; overloading can induce degeneration. The aim of the present study was investigate whether loading regulate chondrocyte degeneration and angiogenesis via inhibitor matrix metalloproteinase‑3 (TIMP3)/transforming growth factor (TGF)‑β1 axis. Primary human chondrocytes were obtained from knee articular a healthy donor. Then, normal or TIMP3 lentivirus‑transfected (LV‑TIMP3) subjected (10 MPa compression). stimulated...
Wave-ice interactions involve complex physical processes. Well-designed laboratory investigations are indispensable for studying these In the present study, experimental data on saline ice obtained during HYDRALAB+ project: Loads Structure and Waves in Ice (LS-WICE) analyzed. Here, we devise a cross-validation method that reduces uncertainty estimating wavelength of surface gravity waves from wave elevation measurements made by closely located equidistant sensors. Both numerical case studies...
ABSTRACT In this study, the adsorptive ability of konjac glucomannan gel containing activated carbon (KGMG–AC) was investigated by measuring removal several organic compounds with different charges, such as nitrobenzene (NB), methylene blue (MB), and rose bengale (RB). The physical chemical properties, adsorption dynamics, isotherms, effect pH adsorbents were compared those a commercially available powdered (AC). results present study indicate that ratio NB, MB, RB onto KGMG–AC slightly...
Abstract Background: Acupuncture treatment possesses the neuroprotection potential to attenuate cerebral ischemia-reperfusion (I/R) injury. Endoplasmic reticulum (ER) stress has been suggested be involved in pathogenic mechanism of I/R Whether acupuncture protects against injury via regulating ER remains unclear. This study aimed evaluate role and its underlying mechanisms. Methods: Cerebral was induced by middle artery occlusion (MCAO) rats. carried out at Baihui (GV 20), Hegu (L14),...