A5082232989- Autophagy in Disease and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Endoplasmic Reticulum Stress and Disease
- Neurological Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Retinal Diseases and Treatments
- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Acupuncture Treatment Research Studies
- Healthcare Systems and Reforms
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Receptor Mechanisms and Signaling
- Advanced Database Systems and Queries
- Hedgehog Signaling Pathway Studies
- Sperm and Testicular Function
- Functional Brain Connectivity Studies
- Chronic Disease Management Strategies
- Cancer, Hypoxia, and Metabolism
- EEG and Brain-Computer Interfaces
- Interprofessional Education and Collaboration
Nankai University
2021-2025
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2015-2024
Kunming University of Science and Technology
2024
Changzhi Medical College
2024
Southwest University
2018-2024
China Agricultural University
2023
Heilongjiang University of Chinese Medicine
2020-2022
State Key Laboratory of Chemical Engineering
2021
State Key Laboratory of Medicinal Chemical Biology
2021
Qilu Hospital of Shandong University
2011-2021
Elevated LDL-cholesterol (LDLc) levels are a major risk factor for cardiovascular disease and atherosclerosis. LDLc is cleared from circulation by the LDL receptor (LDLR). Proprotein convertase subtilisin/kexin 9 (PCSK9) enhances degradation of LDLR in endosomes/lysosomes, resulting increased circulating LDLc. PCSK9 can also mediate lacking its cytosolic tail, suggesting presence as yet undefined lysosomal-targeting factor(s). Herein, we confirm this, eliminate role transmembrane-domain...
Microglia activation is recognized as the hallmark of neuroinflammation. However, profile and phenotype changes microglia during process retinal degeneration are poorly understood. This study aimed to elucidate time-spatial pattern distribution characterize polarized activated neuroinflammation in rd1 (Pde6brd1/rd1) mice, classic model inherited degeneration. Retinae mice at different postnatal days (P7, P14, P21, P28, P56 P180) were prepared for further analysis. We found most CD11b+ or...
Inflammation has emerged to be a critical mechanism responsible for neural damage and neurodegenerative diseases. Microglia, the resident innate immune cells in retina, are implicated as principal components of immunological insult retinal cells. The involvement microglia inflammation is complex here we propose first time that necroptosis triggers neuroinflammation exacerbates degeneration. We found experienced receptor-interacting protein kinase 1 (RIP1)- RIP3-dependent not only...
Eugenol, as an active compound isolated from Acorus gramineus, has been shown to protect against cerebral ischemia-reperfusion (I/R) injury. Nonetheless, the detailed neuroprotective mechanisms of eugenol in I/R injury have not elaborated. In present study, model was established by middle artery occlusion (MCAO) rats. HT22 cells were subjected oxygen-glucose deprivation/reperfusion (OGD/R) mimic vitro. The results showed that pre-treatment relieved evidenced improving neurological deficits...
Abstract Intracerebral hemorrhage (ICH) is a subtype of stroke that followed by primary and secondary brain injury. As result the injury, cell metabolism disrupted series stress responses are activated, such as endoplasmic reticulum (ER) unfolded protein response (UPR), leading to re-establishment homeostasis or death. an important mechanism homeostasis, autophagy has been widely studied, associations between autophagy, ER stress, UPR have also demonstrated. Whether these mechanisms...
Abstract Background Acupuncture treatment possesses the neuroprotection potential to attenuate cerebral ischemia–reperfusion (I/R) injury. Endoplasmic reticulum (ER) stress has been suggested be involved in pathogenic mechanism of I/R Whether acupuncture protects against injury via regulating ER remains unclear. This study aimed evaluate role and its underlying mechanisms. Methods Cerebral was induced by middle artery occlusion (MCAO) rats. carried out at Baihui (GV 20), Qubin (GB7)...
BACKGROUND Proteins play a central role in regulating biological functions, and various pathways regulate their synthesis secretion. Endoplasmic reticulum-associated protein degradation (ERAD) is crucial for monitoring processing unfolded or misfolded proteins actively growing tumor cells. However, the of multiple ERAD complexes liver cancer remains unclear. AIM To elucidate effects SEL1L -mediated on Huh7 explore underlying mechanisms vivo vitro . METHODS cells were treated with inhibitor...
Reexposure to the context associated with heroin intake provokes relapse drug taking after abstinence. The dorsal dentate gyrus (dDG) and entorhinal cortex (EC) have been implicated in contextual memory processing, but underlying circuit mechanisms context-induced remain poorly understood. In this study, using a self-administration rat model, we found that activation synaptic transmission of glutamatergic projections from EC upper blade (dDGub) were significantly enhanced during...
: A mild form of autosomal recessive, nonsyndromal intellectual disability (ARNSID) in humans is caused by a homozygous nonsense mutation the cereblon gene (mutCRBN). Rodent crbn protein binds to intracellular C-terminus large conductance Ca2+-activated K+channel (BKCa). An mRNA variant (human SITE 2 INSERT or mouse strex) BKCa (KCNMA1) that normally expressed during embryonic development aberrantly mutCRBN human lymphoblastoid cell lines (LCLs) as compared wild-type (wt) LCLs. The present...
Integrated care could not only fix up fragmented health but also improve the continuity of and quality life. Despite volume variety publications, little is known about how 'integrated care' has developed. There a need for systematic bibliometric analysis on studying important features integrated literature.To investigate growth pattern, core journals jurisdictions identify key research domains care.We searched Medline/PubMed using search strategy '(delivery care, [MeSH Terms]) OR...
The liver possesses an extraordinary ability to regenerate after injury. Hepatocyte-driven regeneration is the default pathway in response mild-to-moderate acute damage. When replication of mature hepatocytes blocked, facultative hepatic progenitor cells (HPCs), also referred as oval (OCs) rodents, are activated. HPC/OCs have proliferate clonogenically and differentiate into several lineages including bile ductal epithelia. This a conserved injury that has been studied many species ranging...
Neurodegenerative diseases are a set of disorders characterized by progressive neuronal death and associated with microglia-mediated neuroinflammation. Recently, neuroinflammation is proposed as promising therapeutic target for many neurodegenerative diseases. Alpha-1 antitrypsin (AAT) recognized novel immunomodulatory agent in autoimmune transplantation, however, its impact on neurodegeneration remains unknown. This study aims to explore the effects AAT retinal degeneration rd1 mouse model....
The prelimbic cortex (PL) and infralimbic (IL) play a role in context-induced reinstatement of heroin seeking an animal model drug relapse. Both the PL IL receive direct glutamatergic projections from ventral CA1 (vCA1), which is also involved cocaine seeking. Here we studied vCA1-PL vCA1-IL by using electrophysiological, neuropharmacological, chemogenetic, molecular methods. We showed that caused selective activation but not projections, decreased synaptosomal GluA2 expression IL, impaired...
Ovarian cancer (OC) is a frequently occurring malignant tumor in women. Increasing evidence has indicated that long non‑coding RNA (lncRNA) nuclear paraspeckle assembly transcript 1 (NEAT1) participates OC pathogenesis. Thus, the aim of present study was to explore function NEAT1 during progression. The expression levels NEAT1, microRNA (miR)‑4500 and basic leucine zipper W2 domain‑containing protein (BZW1) were assessed via reverse transcription‑quantitative PCR western blotting....
Background: Integrated care not only could fix up the fragmental healthcare caused by ageing of population, changing disease spectrum and fast-growing medical scientific knowledge, also improve continuity quality life.Purpose/Objectives: To investigate growth pattern, languages, core journals, jurisdictions research domains integrated care.Methods: Literature search: The Medline/PubMed was searched using search strategy "(delivery health care, [MeSH Terms]) OR care" without time language...
Notch pathway activation maintains neural stem cells in a proliferating state and increases nerve repair capacity. To date, studies have rarely focused on changes or damage to signal transduction pathways during cerebral hemorrhage. Here, we examined the effect of acupuncture rat model We four groups: control group, rats received no treatment. In hemorrhage models were established by infusing non-heparinized blood into brain. modeled had Baihui (DU20) Qubin (GB7) acupoints treated once day...