A5036171984- Retinal Diseases and Treatments
- Diabetes Treatment and Management
- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Diabetic Foot Ulcer Assessment and Management
- Diabetes and associated disorders
- Retinal Imaging and Analysis
- Mitochondrial Function and Pathology
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- Nuclear Receptors and Signaling
- Pain Mechanisms and Treatments
- Single-cell and spatial transcriptomics
- Advanced Glycation End Products research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Natural Antidiabetic Agents Studies
- Cardiovascular Function and Risk Factors
First Affiliated Hospital of Harbin Medical University
2014-2024
Harbin Medical University
2014-2024
Children's Hospital of Chongqing Medical University
2018
Tungnan University
2010
Introduction: It is known that the metabolic disorder caused by high glucose one of pathogenesis in diabetic retinopathy (DR), leading cause blindness, due to main pathological change apoptosis endothelial cells (ECs). In previous studies, potential impact sodium cotransporter-2 (SGLT-2), whose inhibitors slow progression DR, has not been elucidated. The purpose presented study was explore effect SGLT-2 dapagliflozin (DAPA) on mice retina and human retinal microvascular (HRMECs), examine...
To assess the prevalence of diabetic peripheral neuropathy (DPN) and its risk factors in type 2 diabetes mellitus (T2DM) population.This cross-sectional study enroled patients with T2DM between July December 2017 from 24 provinces China. Diabetic severity were assessed by Toronto clinical scoring system, symptoms score (NSS) disability score. The DPN analysed.A total 14,908 enroled. was 67.6%. Among 10,084 DPN, 4808 (47.7%), 3325 (33.0%), 1951 (19.3%) had mild, moderate, severe respectively....
Astragaloside IV is the main active compound of Astragalus membranaceus. has strong anti-oxidative activities and protective effects against progression peripheral neuropathy. In this study, we determined whether astragaloside protects retinal ganglion cells (RGC) from oxidative stress injury using rat RGC-5 cell line. Hydrogen peroxide (H2O2) was used to induce injury, with effect examined. Cell Counting Kit-8 4′,6-diamidino-2-phenylindole staining showed that increased survival rate...
Introduction: P2X7R excitation-interrelated NLRP3 inflammasome activation induced by high glucose contributes to the pathogenesis of diabetic retinopathy (DR). Relaxin-3 is a bioactive peptide with structure similar insulin, which has been reported be effective in cardiomyopathy models vivo and vitro . However, it not known whether relaxin-3 beneficial impact on DR, underlying mechanisms effect are also remain unknown. Methods Results: The retinas male streptozotocin (STZ)-induced...
Notch pathway activation maintains neural stem cells in a proliferating state and increases nerve repair capacity. To date, studies have rarely focused on changes or damage to signal transduction pathways during cerebral hemorrhage. Here, we examined the effect of acupuncture rat model We four groups: control group, rats received no treatment. In hemorrhage models were established by infusing non-heparinized blood into brain. modeled had Baihui (DU20) Qubin (GB7) acupoints treated once day...
Type 2 diabetes mellitus (T2DM) is a growing burden in low‐and middle‐income countries. Changing lifestyles and lack of physical activity are some the reasons contributing to this epidemic increase. Co‐morbidities associated with T2DM largely due complications which arise as consequence endothelial dysfunction. Platelet derived growth factor‐alpha (PDGFRA) protein responsible for cell proliferation, angiogenesis, migration invasion. Increased levels PDGFRA have been reported T2DM. This study...
OBJECTIVE To investigate the effect on pregnancy outcome of integrating a comprehensive management plan for patients with type 1 diabetes (T1D) into World Health Organization universal maternal care infrastructure. RESEARCH DESIGN AND METHODS A preconception-to-pregnancy women T1D was implemented in 11 centers from 8 Chinese cities 2015 to 2017. Sequential eligible pregnant (n = 133 out 137 initially enrolled) and singleton pregnancies attending these formed prospective cohort. The main...
Background: A number of researches have reported that thyroid hormones are associated with obesity. However, the relationship serum levels in normal range obesity and parameters women childbearing age remains controversial. The purpose this study was to examine within obese Chinese reproductive investigate between concentration indices obesity, including body mass index (BMI), waist-to-hip ratio (WHR), insulin resistance, blood glucose, lipids, pressure. Methods: One hundred fifty-one 160...
The global incidence of ulcerative colitis (UC) continues to increase while it's clinical cure rate remains low. Intestinal mucosal ulcers have segmental distribution and variable severity. bacteria are closely related intestinal immunity metabolism; however, the relationship between microbiome profile occurrence UC, as well contribution glucose metabolism, not understood. This was investigated in present study using biopsies from patients with UC healthy control subjects. We performed high...
Objective Intermittently scanned continuous glucose monitoring (isCGM) is used for unblinded or blinded of interstitial glucose. We aimed to compare the efficacy and isCGM with FreeStyle Libre system glycemic control in adults type 1 diabetes (T1D). Research design methods This randomized clinical trial conducted between October 2018 September 2019 across four endocrinology practices China included 273 aged ≥18 years T1D, who were randomly divided a 2:1 ratio into (n = 199) group 78). In...