A5101529138- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Acupuncture Treatment Research Studies
- Neurosurgical Procedures and Complications
- Healthcare and Venom Research
- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Studies
- Medical Research and Treatments
- Hedgehog Signaling Pathway Studies
- Neurogenesis and neuroplasticity mechanisms
- Botulinum Toxin and Related Neurological Disorders
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Barrier Structure and Function Studies
- Occupational Health and Safety Research
- Obesity and Health Practices
- Cerebrospinal fluid and hydrocephalus
- Risk and Safety Analysis
- Renal Diseases and Glomerulopathies
- Kruppel-like factors research
- Enhanced Recovery After Surgery
- Lipid metabolism and disorders
- Ferroptosis and cancer prognosis
- Facial Nerve Paralysis Treatment and Research
- Biomedical Research and Pathophysiology
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2012-2024
Heilongjiang University of Chinese Medicine
2014-2021
Weifang University
2015-2020
Nanjing Medical University
2009
The purpose of this study was to evaluate the advantages exenatide treatment on obesity and non-alcoholic fatty liver disease (NAFLD) with elevated enzymes in patients type 2 diabetes (T2D).A total 60 newly diagnosed obesity, NAFLD T2D were included study. randomly divided into two groups. group (n = 30) treated insulin glargine, intensive therapy aspart glargine for 12 weeks. Selected clinical characteristics determined, ultrasonography performed at both baseline weeks following...
To study the effect of scalp acupuncture (SA) on mitophagy signaling pathway in caudate nucleus Sprague-Dawley rats following intracerebral hemorrhage (ICH). An ICH model was established by injecting autologous arterial blood into 200 male rats, which were divided five groups: sham, ICH, 3-methyladenine group (3-MA, 30 mg/kg), SA, and SA+3-MA. Animals analyzed at 6 24 h as well 3 7 days. Composite neurological scale score significantly higher SA than group. Transmission electron microscopy...
The acupuncture penetrating line of Baihui (GV20) to Qubin (GB7) spans the parietal, frontal and temporal lobes. present study aimed elucidate mechanism by which electroacupuncture (EA) at GV20‑GB7 regulates mitophagy in intracerebral hemorrhage (ICH) whether it serves a neuroprotective role. A whole blood‑induced ICH model was used. Mitophagy‑regulating proteins, including BCL/adenovirus E1B 19 kDa‑interacting protein 3 (BNIP3), PTEN‑induced putative kinase 1 (PINK1), Parkin...
The CaMK pathway has been proven to play an important role in regulating cognitive function and emotional response. Acupuncture through the improves depression-like behavior molecular mechanism related its antidepressant remains be explored. In this study, we aimed determine whether ability of acupuncture at Baihui (GV20) Shenting (GV24) points treat depression is regulation key proteins pathway. A rat model was induced by chronic unpredicted mild stress (CUMS). Model rats electroacupuncture...
Notch pathway activation maintains neural stem cells in a proliferating state and increases nerve repair capacity. To date, studies have rarely focused on changes or damage to signal transduction pathways during cerebral hemorrhage. Here, we examined the effect of acupuncture rat model We four groups: control group, rats received no treatment. In hemorrhage models were established by infusing non-heparinized blood into brain. modeled had Baihui (DU20) Qubin (GB7) acupoints treated once day...
Baihui (DU20)-penetrating-Qubin (GB7) acupuncture can inhibit inflammatory reactions and activate signaling pathways related to proliferation after intracerebral hemorrhage. However, there is no research showing the relationship between this treatment cell apoptosis. Rat models of hemorrhage were established by injecting 60 μL autologous blood into right side caudate-putamen. Six hours later, needle traveled subcutaneously from acupoint Qubin acupoint. The was alternately rotated (180 ± 10...
Acupuncture is widely used in the treatment of cerebral hemorrhage, and it improves outcomes experimental animal models patients. However, mechanisms underlying effectiveness acupuncture for hemorrhage are still unclear. In this study, a model intracerebral was produced by injecting 50 μL autologous blood into caudate nucleus Wistar rats. at Baihui (DU20) Qubin (GB7) acupoints performed depth 1.0 inch, 12 hours after injection, once every 24 hours. The needle rotated 200 r/min 5 minutes, For...
Blocking the RhoA/ROCK II/MLC 2 (Ras homolog gene family member A/Rho kinase II/myosin light chain 2) signaling pathway can initiate neuroprotective mechanisms against neurological diseases such as stroke, cerebral ischemia, and subarachnoid hemorrhage. Nevertheless, it is not clear whether how disrupting changes pathogenic processes of blood-brain barrier (BBB) after intracerebral hemorrhage (ICH). The present investigation included injection rat caudal vein blood into basal ganglia area to...
Cell division cycle 42 (CDC42) regulates podocyte apoptosis to take part in the development and progression of diabetic nephropathy (DN), but currently clinical evidence is limited. The aim present study was investigate capability serum CDC42 expression level estimate DN patients with diabetes mellitus (DM). Patients type 2 DM (n=306) were enrolled divided into normoalbuminuria (n=185), microalbuminuria (n=72) macroalbuminuria (n=49) groups based on urinary albumin-to-creatinine ratio. Serum...
To compare the clinical curative effect of muscle tension staged acupuncture and conventional in treatment stroke hemiplegia.Sixty-two patients with hemiplegia were randomly divided into an observation group a control group, 31 cases each one. In was given, six stages Brunnstrom classified as relaxation period spasmodic period. The Xingnao Kaiqiao (consciousness-restoring resuscitation) combined hand foot yangming meridian applied at Shuigou (GV 26), Jianyu (LI 15), Quchi 11), Shousanli 10),...
Acupuncture therapy has been widely used in clinical treatment of consciousness, cognitive function, mental and motor disorders after intracerebral hemorrhage (ICH) China, achieved good results. We, the present paper, summarized development studies on underlying mechanism acupuncture for ICH recent 20 years. Outcomes showed that can relieve symptoms by 1) inhibiting inflammatory response, 2) alleviating brain edema, 3) apoptosis, 4) activating autophagy, 5) iron death, 6) oxidative stress,...
Abstract Background Intracerebral hemorrhage (ICH) is a significant global disease with high mortality and disability. As of now, there no effective therapy available. Oxidative stress neuronal apoptosis play essential roles in ICH, determining survival. In our preliminary studies, we found that Baihui‐penetrating‐Qubin acupuncture could improve neurological deficits neuropathological damage the perihematomal area ICH rats. The SIRT1/FOXO1 signaling pathway has been reported to mediate...
To investigate the effects of acupuncture on JNK pathway and autophagy level in rats with intracerebral hemorrhage （ICH） explore partial mechanism against ICH.SD were randomly divided into blank group, model group group. Each was Day 1, 3 7 subgroups respectively, 5 each The autologous blood injection adopted to duplicate rat ICH. In needle inserted from "Baihui" （GV20） towards "Qubin" （GB7） affected side, stimulating for 30 min time, once daily； same technique opera-ted subgroup days,...