A5039138350- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Immune cells in cancer
- Neurosurgical Procedures and Complications
- Pituitary Gland Disorders and Treatments
- RNA modifications and cancer
- Pain Mechanisms and Treatments
- Immune Cell Function and Interaction
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Synthesis and Biological Evaluation
- Neurogenesis and neuroplasticity mechanisms
- Quinazolinone synthesis and applications
- Olfactory and Sensory Function Studies
- Cerebrospinal fluid and hydrocephalus
- Inflammasome and immune disorders
- Nuclear Receptors and Signaling
- Peroxisome Proliferator-Activated Receptors
- Histone Deacetylase Inhibitors Research
- Nerve injury and regeneration
- Meningioma and schwannoma management
Southern Medical University
2019-2025
Zhujiang Hospital
2019-2025
Nanjing University
2020-2022
Deafferentation pain (DP), a typical neuropathic pain, occurs due to peripheral or central sensory nerve injury, which causes abnormal discharge of the upstream neurons C fibers. Current treatment methods for DP have multiple side effects. Bone marrow mesenchymal stem cells (BMSC) been used treat because their ability regulate neuroinflammation. Glial cell-derived neurotrophic factor (GDNF) is mediator that exerts neuroprotective effects in neurological diseases. In this study, we...
Neuroinflammatory reactions are crucial factors in secondary brain damage following intracerebral hemorrhage (ICH). Although previous studies have shown that IRAK3 is involved immune responses, the potential effects of on ICH remain unclear. Collagenase IV-induced mouse model. Western blotting was used to determine expression at different time points ICH. Immunofluorescence investigate cellular localization IRAK3. The model treated with recombinant human (rh-IRAK3) or siRNA via an...
Autophagy and NLRP3 inflammasome were associated with the process of colitis. Drugs targeting autophagy to treat colitis are absent, they urgently required. Herein, we examine effect evodiamine, extracted from fruit Evodiae Fructus, on experimental induced by DSS exposit whether evodiamine effects inflammasome. Our data indicated that was ameliorated including improvement mice body weight, colon length, histopathologic score, disease activity index. We also observed restrained formation...
Neuroinflammation plays an important role following intracerebral hemorrhage (ICH). NLRP3 inflammasome-mediated pyroptosis contributes to the mechanism of neuroinflammation. It has been reported that dendritic cell-associated C-type lectin-1 (Dectin-1) activation triggers inflammation in neurological diseases. However, Dectin-1 on after ICH remains unclear. Here, we aimed explore effect and neuroinflammation ICH.Adult male C57BL/6 mice were used establish model. Laminarin, inhibitor...
Neuroinflammation is associated with the pathogenesis of all types neurological disease, in which microglial cells play a critical role. In response to disturbances microenvironment, microglia (MG) become activated and differentiate into either an M1 phenotype, has proinflammatory damaging effect, or M2 plays anti-inflammatory reparative Thus, modulating polarization suitable strategy treat neuroinflammatory disorders. Glial cell-derived neurotrophic factor (GDNF) mediator that exerts...
Lipid‐laden macrophages are considered as the main source of foam cells in atherosclerosis; however, mechanism for macrophage cell formation remains unknown. Here, we explore behind to potentially identify a novel treatment atherosclerosis. Our data demonstrated that leucine‐rich pentatricopeptide repeat‐containing protein (LRPPRC) increased atherosclerotic plaques LDLR −/− mice fed with Western diet. LRPPRC was also upregulated peritoneal and RAW 264.7 treated oxidative low density...
BACKGROUNDNonfunctional pituitary adenoma is a common type of adenoma, which can lead to headache, visual field disturbance, and cranial nerve damage due increased tumor volume.Neuroendoscopic microscopic transsphenoidal approaches have been widely used in the resection nonfunctional adenomas.However, clinical efficacy neuroendoscopic surgery still controversial. AIMTo explore approach for adenomas. METHODSWe retrospectively analyzed 251 patients with adenomas; 138 underwent via approach,...
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Abstract Background Pro-inflammatory signals generated after intracerebral hemorrhage (ICH) trigger a form of regulated cell death known as pyroptosis in microglia. Although the p2Y purinoceptor 6 (P2RY6) plays significant role control inflammatory reactions central nervous system diseases, its roles development neuroinflammation and microglial following ICH remain unclear. Methods Type IV collagenase was injected to induce ICH. Mice were then treated with MRS2578 LY294002 inhibit P2RY6...