A5064727849- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Inflammasome and immune disorders
- Acute Ischemic Stroke Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
Zhujiang Hospital
2022-2025
Southern Medical University
2022-2025
Neuroinflammatory reactions are crucial factors in secondary brain damage following intracerebral hemorrhage (ICH). Although previous studies have shown that IRAK3 is involved immune responses, the potential effects of on ICH remain unclear. Collagenase IV-induced mouse model. Western blotting was used to determine expression at different time points ICH. Immunofluorescence investigate cellular localization IRAK3. The model treated with recombinant human (rh-IRAK3) or siRNA via an...
Neuroinflammation plays an important role following intracerebral hemorrhage (ICH). NLRP3 inflammasome-mediated pyroptosis contributes to the mechanism of neuroinflammation. It has been reported that dendritic cell-associated C-type lectin-1 (Dectin-1) activation triggers inflammation in neurological diseases. However, Dectin-1 on after ICH remains unclear. Here, we aimed explore effect and neuroinflammation ICH.Adult male C57BL/6 mice were used establish model. Laminarin, inhibitor...