A5062815019- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Viral-associated cancers and disorders
- Virus-based gene therapy research
- T-cell and Retrovirus Studies
- Aquaculture disease management and microbiota
- Animal Disease Management and Epidemiology
- Animal Virus Infections Studies
- Vector-Borne Animal Diseases
- Poxvirus research and outbreaks
- Immune Cell Function and Interaction
- Toxoplasma gondii Research Studies
- Viral Infections and Vectors
- Viral gastroenteritis research and epidemiology
- Toxin Mechanisms and Immunotoxins
- Immune Response and Inflammation
- Asthma and respiratory diseases
- Turtle Biology and Conservation
- IL-33, ST2, and ILC Pathways
- Microbial infections and disease research
- Plant Virus Research Studies
- Fish Ecology and Management Studies
- Cytokine Signaling Pathways and Interactions
- NF-κB Signaling Pathways
- Bacteriophages and microbial interactions
University of Liège
2015-2024
Walloon Excellence in Lifesciences and Biotechnology
2024
The Farah Hospital
2017-2021
University of Veterinary Medicine
2013
University of Parma
2006
Bipar
2005
Imperial College London
2002
Physiol (Belgium)
2002
Sanford Burnham Prebys Medical Discovery Institute
2000
University of Oxford
1997-1999
The respiratory tract is continuously exposed to both innocuous airborne antigens and immunostimulatory molecules of microbial origin, such as LPS. At low concentrations, LPS can induce a lung DC-driven Th2 cell response harmless inhaled antigens, thereby promoting allergic asthma. However, only small fraction people environmental develop What prevents most from mounting upon exposure not understood. Here we have shown that interstitial macrophages (IMs), population with no previously...
Vaccinia virus (VV) produces two antigenically and structurally distinct infectious virions, intracellular mature (IMV) extracellular enveloped (EEV). Here we have investigated the resistance of EEV IMV to neutralization by complement in absence immune antibodies. When is challenged with from same species as cells used grow virus, resistant complement, whereas not. was not a result protein B5R, despite its similarity proteins regulators activation (RCA) family, or any other tested (A34R,...
Cyprinid herpesvirus 3 (CyHV-3) is the aetiological agent of a mortal and highly contagious disease in common koi carp. The skin major portal entry CyHV-3 carp after immersion water containing virus. In present study, we used vivo bioluminescence imaging to investigate effect mucus removal epidermis lesion on entry. Physical treatments inducing up complete erosion were applied defined area just before inoculation by infectious water. was drastically enhanced where removed with or without...
Abstract Infection with parasitic helminths can imprint the immune system to modulate bystander inflammatory processes. Bystander or virtual memory CD8 + T cells (T VM ) are non-conventional displaying properties that be generated through responsiveness interleukin (IL)-4. However, it is not clear if helminth-induced type 2 immunity functionally affects compartment. Here, we show expand CD44 hi CD62L CXCR3 CD49d lo direct IL-4 signaling in cells. Importantly, helminth-mediated conditioning...
Vaccinia virus (VV) produces two antigenically distinct infectious virions, intracellular mature (IMV) and extracellular enveloped (EEV). Structurally, EEV consists of an IMV with additional outer membrane containing proteins that are absent from IMV. is important for dissemination both in vitro vivo. Studies entry have been hampered by having virions the rupture majority during their purification. To overcome these problems, we developed a novel approach to study VV based on confocal...
ABSTRACT Vaccinia virus (VV) morphogenesis commences with the formation of lipid crescents that grow into spherical immature (IV) and then infectious intracellular mature (IMV) particles. Early studies proposed were synthesized de novo matured IMV particles contained a single bilayer (S. Dales E. H. Mosbach, Virology 35:564–583, 1968), but more recent study reported crescent was derived from membranes intermediate compartment (IC) double (B. Sodiek et al., J. Cell Biol. 121:521–541, 1993)....
ABSTRACT Koi herpesvirus (KHV), recently designated Cyprinid 3 , is the causative agent of a lethal disease in koi and common carp. In present study, we investigated portal entry KHV carp by using bioluminescence imaging. Taking advantage recent cloning genome as bacterial artificial chromosome (BAC), produced recombinant plasmid encoding firefly luciferase (LUC) expression cassette inserted intergenic region between open reading frame (ORF) 136 ORF 137. Two viral strains were then...
Transmission is a matter of life or death for pathogen lineages and can therefore be considered as the main motor their evolution. Gammaherpesviruses are archetypal pathogenic persistent viruses which have evolved to transmitted in presence specific immune response. Identifying mode transmission mechanisms evasion essential develop prophylactic therapeutic strategies against these infections. As known human gammaherpesviruses, Epstein-Barr virus Kaposi's Sarcoma-associated Herpesvirus...
Both endotherms and ectotherms (e.g., fish) increase their body temperature to limit pathogen infection. Ectotherms do so by moving warmer places, hence the term "behavioral fever." We studied manifestation of behavioral fever in common carp infected cyprinid herpesvirus 3, a native pathogen. Carp maintained at 24°C died from infection, whereas those housed multi-chamber tanks encompassing 24°C–32°C gradient migrated transiently warmest compartment survived as consequence. Behavioral...
Abstract In most cells trans-activating NF-κB induces many inflammatory proteins as well its own inhibitor, IκB-α, thus assuring a transient response upon stimulation. However, NF-κB-dependent gene expression is persistent in asthmatic bronchi, even after allergen eviction. the present report we used bronchial brushing samples (BBSs) from heaves-affected horses (a spontaneous model of asthma) to elucidate mechanisms by which activity maintained airways. was high granulocytic and...
Vaccinia virus (VV) produces two antigenically and structurally distinct infectious virions, intracellular mature (IMV) extracellular enveloped (EEV), which bind to unidentified possibly different cellular receptors. Studies of VV binding have been hampered by having virions the rupture EEV outer membrane in majority during purification. To overcome these problems, we developed a novel approach study that is based on confocal microscopy does not require In this assay, individual particles...
Abstract The alternative pathway of complement is an important innate defence against pathogens including ticks. This component the immune system has selected for that have evolved countermeasures. Recently, a salivary protein able to inhibit was cloned from American tick Ixodes scapularis (Valenzuela et al ., 2000; J. Biol. Chem. 275, 18717–18723). Here, we isolated two different sequences, similar Isac, transcriptome I. ricinus glands. Expression these sequences revealed they both encode...
Koi herpesvirus, also known as cyprinid herpesvirus 3 (CyHV-3), is the aetiological agent of an emerging and mortal disease in common koi carp. CyHV-3 virions present characteristic morphology other members order Herpesvirales, being composed envelope, a capsid containing genome tegument. This study identified structural proteins corresponding encoding genes using liquid chromatography tandem mass spectrometry-based proteomic approaches. In addition, exponentially modified protein abundance...