A5004922331- Parasitic infections in humans and animals
- Congenital Anomalies and Fetal Surgery
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Viral gastroenteritis research and epidemiology
- Parasitic Infections and Diagnostics
- Zoonotic diseases and public health
- Vector-Borne Animal Diseases
- Child Nutrition and Water Access
- Vaccine Coverage and Hesitancy
- Parasitic Diseases Research and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Viral Infections and Immunology Research
- Food Safety and Hygiene
- Health Systems, Economic Evaluations, Quality of Life
- Animal Disease Management and Epidemiology
- Data Analysis with R
- Global Health Care Issues
- Prion Diseases and Protein Misfolding
- SARS-CoV-2 and COVID-19 Research
- Health disparities and outcomes
- Trypanosoma species research and implications
- Agriculture and Farm Safety
- Vector-borne infectious diseases
- Malaria Research and Control
Janssen (United States)
2025
Janssen (Belgium)
2025
GlaxoSmithKline (Belgium)
2016-2022
Instituut voor Tropische Geneeskunde
2010-2021
Universidad Peruana Cayetano Heredia
2015
Johns Hopkins University
2015
Instituto Nacional de Ciencias Neurológicas
2015
National University of San Marcos
2015
Institute of Peruvian Studies
2015
University of Zambia
2014
Illness and death from diseases caused by contaminated food are a constant threat to public health significant impediment socio-economic development worldwide. To measure the global regional burden of foodborne disease (FBD), World Health Organization (WHO) established Foodborne Disease Burden Epidemiology Reference Group (FERG), which here reports their first estimates incidence, mortality, due 31 hazards. We find that FBD is comparable those major infectious diseases, HIV/AIDS, malaria...
Taenia solium cysticercosis is an important zoonosis in many developing countries. Human neurocysticercosis recognised as cause of epilepsy regions where the parasite occurs. However, it largely underreported and there a lack data about disease burden. Because body information on human porcine Cameroon becoming available, present study was undertaken to calculate impact this neglected zoonosis.Both cost Disability Adjusted Life Year (DALY) estimations were applied. All necessary parameters...
Background The Foodborne Disease Burden Epidemiology Reference Group (FERG) was established in 2007 by the World Health Organization to estimate global burden of foodborne diseases (FBDs). This paper describes methodological framework developed FERG's Computational Task Force transform epidemiological information into FBD estimates. Methods and Findings regional 31 FBDs quantified, along with limited estimates for 5 other FBDs, using Disability-Adjusted Life Years a hazard- incidence-based...
Studies sometimes estimate the prevalence of a disease from results one or more diagnostic tests that are applied to individuals unknown status. This approach invariably means that, in absence gold standard and without external constraints, parameters must be estimated than data permit. Two assumptions regularly made literature, namely test characteristics (sensitivity specificity) constant over populations conditionally independent given true These have been criticized recently as being...
Background Taenia solium taeniosis/cysticercosis is a parasitic infection occurring in many developing countries. Data on the status of human infections Zambia largely lacking. We conducted community-based study Eastern to determine prevalence taeniosis and cysticercosis rural community. Methods Findings Stool serum samples were collected from willing participants. Geographical references participants' households determined household questionnaires administered. Taeniosis was diagnosed stool...
Abstract Objective To estimate and compare the performances of coprology, copro‐Ag ELISA real‐time polymerase chain reaction assay (copro‐ PCR ) for detection T aenia solium tapeworm carriers. Methods The three diagnostic tests were applied on 817 stool samples collected in two Z ambian communities where taeniasis is endemic. A B ayesian approach was used to allow estimation test characteristics. Two (0.2%; 95% Confidence Interval ( CI ): 0–0.8), 67 (8.2%; : 6.4–10.3) 10 (1.2%; 0.5–2.2)...
A community-based longitudinal study was performed in the Eastern Province of Zambia, which repeated serological samplings were done to determine incidence human cysticercosis. Three sampling rounds carried out at six months intervals. total 867 participants presented for all three samplings. All samples tested presence cysticercus antigens using a monoclonal antibody-based enzyme-linked immunosorbent assay (sero-Ag-ELISA), while randomly selected sub-sample 161 from each round specific...
Abstract The alternative pathway of complement is an important innate defence against pathogens including ticks. This component the immune system has selected for that have evolved countermeasures. Recently, a salivary protein able to inhibit was cloned from American tick Ixodes scapularis (Valenzuela et al ., 2000; J. Biol. Chem. 275, 18717–18723). Here, we isolated two different sequences, similar Isac, transcriptome I. ricinus glands. Expression these sequences revealed they both encode...
Background Taenia solium, a zoonotic parasite that is endemic in most developing countries where pork consumed, recognised as the main cause of acquired epilepsy these regions. T. solium has been reported almost all neighboring Democratic Republic Congo (DRC) but data on current prevalence disease country itself are lacking. This study, focusing porcine cysticercosis (CC), makes part first initiative to assess whether indeed actually present DRC. Methods An epidemiological study CC was...
Zambia is endemic for Taenia solium taeniosis and cysticercosis. In this single-centered, cross-sectional, community-based study, the role of neurocysticercosis (NCC) as a cause epilepsy was examined. People with (PWE, n = 56) were identified in an area using screening questionnaire followed by in-depth interviews neurological examination. Computed tomography (CT) performed on 49 people active (PWAE) their sera (specific antibody antigen detection, stools (copro-antigen 54) analyzed. The CT...
Abstract Background Following a 30-year development process, RTS,S/AS01 E (GSK, Belgium) is the first malaria vaccine to reach Phase IV assessments. The World Health Organization-commissioned Malaria Vaccine Implementation Programme (MVIP) coordinating delivery of through routine national immunization programmes in areas 3 countries sub-Saharan Africa. doses were given participating MVIP Malawi on 23 April, Ghana 30 and Kenya 13 September 2019. have little or no baseline incidence data rare...
Abstract Background Ad26.COV2.S (Janssen COVID-19 Vaccine) is a replication-incompetent viral-vector vaccine used in the international response to SARS-CoV-2 pandemic. id.DRIVE (previously COVIDRIVE) public private partnership that conducts infectious disease studies on vaccines and therapeutics European region. Here we present post-authorization study assessing effectiveness (VE) of single dose against hospitalization. Methods The was non-interventional, multicentric, combined retrospective...
JCOVDEN (Ad26.COV2.S), a viral-vector vaccine, was granted conditional marketing authorisation in the European Union for prevention of COVID-19 early 2021. We present single-dose vaccine effectiveness (VE) estimates against hospitalisation. The id.DRIVE (previously COVIDRIVE) VE study is an ongoing non-interventional, multi-centre with test-negative case-control design. Study participants were adults ≥ 18 years old, hospitalised severe acute respiratory infection between 1 May 2021 and 28...