A5002334565- RNA regulation and disease
- Cancer Treatment and Pharmacology
- Colorectal Cancer Treatments and Studies
- Marine and coastal plant biology
- Marine Biology and Ecology Research
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Lung Cancer Treatments and Mutations
- Prenatal Screening and Diagnostics
- DNA and Nucleic Acid Chemistry
- Gastric Cancer Management and Outcomes
- interferon and immune responses
- Lung Cancer Research Studies
- Marine and coastal ecosystems
- CRISPR and Genetic Engineering
- Assisted Reproductive Technology and Twin Pregnancy
- Hepatocellular Carcinoma Treatment and Prognosis
- Herpesvirus Infections and Treatments
- Congenital Heart Disease Studies
- Coral and Marine Ecosystems Studies
- Genetic factors in colorectal cancer
- HER2/EGFR in Cancer Research
- Health and Medical Research Impacts
- Advances in Oncology and Radiotherapy
- Neuroendocrine Tumor Research Advances
Instituto Gulbenkian de Ciência
2010-2022
Aristotle University of Thessaloniki
2004-2019
Hellenic Oncology Research Group
2004-2019
Massachusetts Institute of Technology
2001-2018
Lehigh University
2004-2018
Senologic Hellenic Society
2014-2018
Imperial College London
2015-2016
404 General Military Hospital
2016
Transnational Press London
2015-2016
University Hospital of Larissa
2005-2015
RNA editing by adenosine deamination generates and protein diversity through the posttranscriptional modification of single nucleotides in sequences. Few mammalian A-to-I edited genes have been identified despite evidence that many more should exist. Here we identify intramolecular pairs Alu elements as a major target for human transcriptome. An experimental demonstration 43 was extended broader computational analysis than 100,000 mRNAs. We find 1,445 mRNAs (1.4%) are subject to at 14,500...
To compare the efficacy and toxicity of oxaliplatin (L-OHP) in combination with irinotecan (CPT-11), 5-fluorouracil (5-FU) leucovorin (LV) (FOLFOXIRI) vs 5-FU/LV (FOLFIRI) as first-line treatment patients metastatic colorectal cancer (MCC). A total 283 chemotherapy-naïve MCC were enrolled (FOLFIRI arm: n=146; FOLFOXIRI n=137). In arm, CPT-11 (150 mg m(-2)) was given on d1, L-OHP (65 d2, LV (200 days 2 3 5-FU (400 m(-2) i.v. bolus 600 22 h continuous infusion) 3. FOLFIRI (180 d1 whereas...
The eukaryotic cell division cycle is coordinated by cyclin-dependent kinases (CDKs), represented a single major serine/threonine kinase in yeasts (Cdc2/CDC28) and family of (CDK1 to CDK8) human cells. Previously, two cdc2 homologs, cdc2MsA cdc2MsB, have been identified alfalfa (Medicago sativa). By isolating cDNAs using probe, we demonstrate here that at least four additional homologous genes are expressed the tetraploid alfalfa. Proteins encoded new cdc2MsC cdc2MsF share characteristic...
Despite their fundamental importance for body size regulation, the mechanisms that stop growth are poorly understood. In Drosophila melanogaster, ceases in response to a peak of molting hormone ecdysone coincides with nutrition-dependent checkpoint, critical weight. Previous studies indicate insulin/insulin-like factor signaling (IIS)/Target Rapamycin (TOR) prothoracic glands (PGs) regulates biosynthesis and Here we elucidate mechanism through which this occurs. We show Forkhead Box class O...
We report quantitative, real-time, online observations of microscopic viscosity changes in aerosol particles atmospherically relevant composition, using fluorescence lifetime imaging (FLIM) viscosity.
Root vacuolar sequestration is one of the best-conserved plant strategies to cope with heavy metal toxicity. Here we report that zinc (Zn) tolerance in Arabidopsis requires action a novel Major Facilitator Superfamily (MFS) transporter. We show ZIF2 (Zinc-Induced 2) localises primarily at tonoplast root cortical cells and functional transporter able mediate Zn efflux when heterologously expressed yeast. By affecting tissue partitioning ion, loss function exacerbates sensitivity excess Zn,...
Both endotherms and ectotherms (e.g., fish) increase their body temperature to limit pathogen infection. Ectotherms do so by moving warmer places, hence the term "behavioral fever." We studied manifestation of behavioral fever in common carp infected cyprinid herpesvirus 3, a native pathogen. Carp maintained at 24°C died from infection, whereas those housed multi-chamber tanks encompassing 24°C–32°C gradient migrated transiently warmest compartment survived as consequence. Behavioral...
We describe a technique to measure the viscosity of stably levitated single micron-sized aerosol particles. Particle levitation allows phase be probed in absence potentially artefact-causing surfaces. To achieve this feat, we combined two laser based techniques: optical trapping for particle levitation, using counter-propagating beam configuration, and fluorescent lifetime imaging microscopy (FLIM) molecular rotors measurement within particle. Unlike other techniques used viscosity,...
The FoxP gene subfamily of transcription factors is defined by its characteristic 110 amino acid long DNA-binding forkhead domain and plays essential roles in vertebrate biology.Its four members, FoxP1-P4, have been extensively characterized functionally.FoxP1, FoxP2, FoxP4 are involved lung, heart, gut, central nervous system (CNS) development.FoxP3 necessary sufficient for the specification regulatory T cells (Tregs) adaptive immune system.In Drosophila melanogaster, silico predictions...
The double helix of DNA, when composed dinucleotide purine-pyrimidine repeats, can adopt a left-handed helical structure called Z-DNA. For reasons not entirely understood, such repeats in genomic sequences have been associated with instability leading to cancer. Adoption the conformation results formation conformational junctions: A B-to-Z junction is formed at boundaries helix, whereas Z-to-Z commonly where repeat interrupted by single base insertions or deletions that bring neighboring...
In vertebrate species, the innate immune system down-regulates protein translation in response to viral infection through action of double-stranded RNA (dsRNA)-activated kinase (PKR). some teleost species another kinase, Z-DNA-dependent (PKZ), plays a similar role but instead dsRNA binding domains, PKZ has Zα domains. These domains recognize left-handed conformer dsDNA and known as Z-DNA/Z-RNA. Cyprinid herpesvirus 3 infects common koi carp, which have PKZ, encodes ORF112 that itself bears...
The aim of this study was to compare the irinotecan/cisplatin regimen with cisplatin as second-line chemotherapy in patients advanced non-small-cell lung cancer (NSCLC) pretreated a taxane/gemcitabine regimen. Patients (n=147) stage IV NSCLC were randomly assigned receive either irinotecan (110 mg m−2, day 1 and 100 8) (80 (IC; n=74) or CDDP 1) (C; n=73) every 3 weeks. treated IC C had median survival 7.8 8.8 months, respectively (P=0.933). 1-year rate 34.3% for IC-treated 31.7% C-treated...
The RNA-dependent protein kinase PKR plays a central role in the antiviral defense of vertebrates by shutting down translation upon detection viral dsRNA cytoplasm. In some teleost fish, PKZ, homolog PKR, performs same function, but surprisingly, instead binding domains, it harbors two Z-DNA/Z-RNA-binding domains belonging to Zalpha domain family. have also been found other proteins, which key roles regulation interferon responses such as ADAR1 and DNA-dependent activator IFN-regulatory...
ABSTRACT Zalpha domains are a subfamily of the winged helix-turn-helix sharing unique ability to recognize CpG repeats in left-handed Z-DNA conformation. In vertebrates, this family found exclusively proteins that detect foreign nucleic acids and activate components antiviral interferon response. Moreover, poxviruses encode domain-containing protein E3L, well-studied potent inhibitor Here we describe herpesvirus Zalpha-domain-containing (ORF112) from cyprinid 3. We demonstrate ORF112 also...