A5101546800- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Cardiovascular Health and Risk Factors
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cardiovascular Health and Disease Prevention
- Cancer-related molecular mechanisms research
- Cardiac Fibrosis and Remodeling
- Noise Effects and Management
- Ferroptosis and cancer prognosis
- Heart Rate Variability and Autonomic Control
- Heart Failure Treatment and Management
- Blood Pressure and Hypertension Studies
- Cardiac Structural Anomalies and Repair
- Peptidase Inhibition and Analysis
- Aortic aneurysm repair treatments
- Cardiac Ischemia and Reperfusion
- Aortic Disease and Treatment Approaches
- Cancer, Stress, Anesthesia, and Immune Response
- Autophagy in Disease and Therapy
- Cardiac Valve Diseases and Treatments
- Spinal Cord Injury Research
- Inflammatory mediators and NSAID effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Nanjing Drum Tower Hospital
2016-2025
Nanjing Medical University
2019-2025
Guangzhou Medical University
2024-2025
Shanghai Jiao Tong University
2024
Henan Provincial Chest Hospital
2003-2024
Zhengzhou University
2024
Tongren Hospital
2024
Nanjing University of Chinese Medicine
2024
Hebei Medical University
2014-2023
Second Hospital of Shandong University
2022
Importance Most epidemiological studies of heart failure (HF) have been conducted in high-income countries with limited comparable data from middle- or low-income countries. Objective To examine differences HF etiology, treatment, and outcomes between groups at different levels economic development. Design, Setting, Participants Multinational registry 23 341 participants 40 high-income, upper–middle-income, lower–middle-income, countries, followed up for a median period 2.0 years. Main...
Background: Consensus is lacking with regard to whether hearing loss an independent risk factor for dementia. We therefore conducted a meta-analysis clarify the relationship of and Methods: Prospective cohort studies investigating association between incidence dementia in community-derived population were included by searching electronic databases that PubMed, Embase, Cochrane's Library. A random-effects model was adopted combine results. Results: Fourteen cohorts including 726,900...
Hepatocellular carcinoma (HCC) is the most common fatal cancer worldwide, patients with HCC have a high mortality rate and poor prognosis.PANoptosis novel discovery of programmed cell death associated development.However, role PANoptosis in remains obscure.In this study, we enrolled 274 PANoptosisrelated genes (PANRGs) screened 8 to set up prognostic model.A previous scoring system calculated PANscore was utilized quantify individual risk level each patient, reliability model has been...
<p indent="0mm">Chronic renal failure (CRF) is a severe syndrome affecting the urinary system for which there are no effective therapeutics. In this study, we investigate effects and mechanisms of aminophylline in preventing CRF development. A rat model chronic established by 5/6 nephrectomy. The levels serum creatinine (SCR), protein (UPR), blood urea nitrogen (BUN) detected ELISA. Histological evaluations tissues performed H&E, Masson staining, PAS staining. Functional expression...
Infectious episodes contribute to morbidity and mortality in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Renal involvement, also known as ANCA-associated glomerulonephritis (AGN), is frequently observed AAV. Little about whether co-infection at initial diagnosis associated renal outcome prognosis children AGN. Clinical prognostic data for admitted our center AAV from January 2001 August 2023 were analyzed retrospectively. We compared the incidence...
Purpose: Stanford Type B Aortic Dissection (TBAD), a critical aortic disease, has exhibited stable mortality rates over the past decade. However, diagnostic approaches for TBAD during routine health check-ups are currently lacking. This study focused on developing model to improve diagnosis in population. Patients and Methods: Serum biomarkers were investigated 88 participants using proteomic profiling combined with machine learning. The findings validated ELISA other 80 participants....
The employment of platinum-based drugs for cancer chemotherapy, which might yield oxidative stress, is regarded as one main factor leading to hearing loss. exact molecular mechanisms cisplatin-induced loss require further clarification, thus limiting the development FDA-approved therapies. Herein, we mimicked structure natural antioxidative enzymes fabricate a four-oxygen-coordinating copper single-atom nanozyme (Cu SAN) exhibiting good superoxide dismutase and catalase activity, alleviate...
Abstract Hearing is one of the most vital sensory functions in human beings and a crucial means perceiving acquiring information from natural environment. The advancement society closely linked to development language, with hearing serving as foundation for verbal communication. As individuals age, deterioration auditory system becomes significant factor contributing impairments elderly. In addition loss, aging also associated cognitive decline psychosocial disorders, which severely impact...
Purine metabolism is a promising therapeutic target in cancer; however how cancer cells respond to purine shortage,particularly their adaptation and vulnerabilities, remains unclear. Using the recently developed shortage-inducing prodrug DRP-104 genetic approaches, we investigated these responses prostate, lung glioma models. We demonstrate that when de novo biosynthesis compromised, employ microtubules assemble purinosomes, multi-protein complexes of enzymes enhance efficiency. While this...
Acute rhinosinusitis is among the most prevalent disease across world. Recently, researchers have found that traditional Chinese medicine (TCM) can effectively treat acute rhinosinusitis. Nanomaterial-based drug delivery systems (DDSs) attracted widespread attention in treatment. In this work, we herein reported curcumin-loading black phosphorus nanosheet (BP-C@PEG) nanodrugs for therapy. The as-prepared BP-C@PEG showed excellent solubility and stability aqueous solution performed sustained...
Aberrant expression and structural alterations of microRNAs (miRNAs) play important roles in tumorigenesis. The miRNA-196a2 polymorphism is associated with tumorigenesis, but its association non-Hodgkin lymphoma (NHL) remains unexplored. We evaluated the between T>C (rs11614913) NHL risk a case-control study 318 cases 320 healthy controls. also examined miRNA-196a tissue samples from patients (n = 59). TC CC genotypes were cancer [odds ratio (OR) 1.384, confidence interval (CI) 1.010-1.898...
Sensorineural hearing loss (SNHL) is the most common form of sensory deprivation and often unrecognized by patients, inducing not only auditory but also nonauditory symptoms. Data-driven classifier modeling with combination neural static dynamic imaging features could be effectively used to classify SNHL individuals healthy controls (HCs).
Background: Older adults with hypertension often had diminished walking performance. The underlying mechanism through which affects performance, however, has not been fully understood. We here measured the complexity of continuous systolic (SBP) and diastolic (DBP) blood pressure fluctuation, grade white matter lesions (WMLs), cognitive function used structural equation modeling (SEM) to examine interrelationships between hypertension, BP complexity, WMLs, function, speed in single-...
The blood pressure (BP) is regulated by multiple neurophysiologic elements over temporal scales. multiscale dynamics of continuous beat-to-beat BP series, which can be characterized "BP complexity", may, thus, capture the subtle changes those elements, and associated with level functional status in older adults. We aimed to characterize relationships between complexity several important functions adults understand underlying factors contributing complexity.A total 400 completed a series...
This study aimed to investigate the hearing threshold among different age groups, genders, and geographic areas in China provide some insight into appropriate clinical interventions for loss.Using a systematic random sampling technique, 562 participants from Qinling, Qinghai, Nanjing were included. Participants same area divided 3 groups according their age. Pure-tone audiometric thresholds measured at octave interoctave frequencies of 0.125-16 kHz each subject.There significant differences...
We seek to compare the early and late outcomes of reperfusion-first versus central repair-first strategies in patients with acute type A dissection (ATAAD) complicated by mesenteric malperfusion.