A5101398406- Orthopaedic implants and arthroplasty
- Antibiotics Pharmacokinetics and Efficacy
- Nanoplatforms for cancer theranostics
- Orthopedic Infections and Treatments
- Antibiotic Resistance in Bacteria
- Air Quality and Health Impacts
- Musculoskeletal synovial abnormalities and treatments
- RNA Interference and Gene Delivery
- Smoking Behavior and Cessation
- Pneumonia and Respiratory Infections
- Spinal Fractures and Fixation Techniques
- Climate Change and Health Impacts
- Receptor Mechanisms and Signaling
- Medical Imaging and Analysis
- Aortic aneurysm repair treatments
- Bone Tissue Engineering Materials
- Lung Cancer Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Macrophage Migration Inhibitory Factor
- Multicomponent Synthesis of Heterocycles
- Hip and Femur Fractures
- Scoliosis diagnosis and treatment
- COVID-19 impact on air quality
- Epigenetics and DNA Methylation
- Indoor Air Quality and Microbial Exposure
Jiangsu University
2011-2025
Nanjing Drum Tower Hospital
2023-2025
University of Houston
2025
Xuzhou Medical College
2023-2024
Huashan Hospital
2023-2024
Fudan University
2023-2024
Henan Provincial People's Hospital
2004-2024
Hunan Cancer Hospital
2023-2024
Central South University
2023-2024
West China Hospital of Sichuan University
2024
Abstract Infective bone defect is increasingly threatening human health. How to achieve the optimal antibacterial activity and regenerative repair of infective simultaneously a huge challenge in clinic. Herein, this work reports rational integration Mn single‐atom nanozyme into 3D‐printed bioceramic scaffolds (Mn/HSAE@BCP scaffolds). The integrated Mn/HSAE@BCP can catalyze conversion H 2 O produce hydroxyl radical ( • OH) superoxide anion (O •− ) through cascade reaction. Besides, prominent...
Purpose: Stanford Type B Aortic Dissection (TBAD), a critical aortic disease, has exhibited stable mortality rates over the past decade. However, diagnostic approaches for TBAD during routine health check-ups are currently lacking. This study focused on developing model to improve diagnosis in population. Patients and Methods: Serum biomarkers were investigated 88 participants using proteomic profiling combined with machine learning. The findings validated ELISA other 80 participants....
Abstract Purpose This study investigates the impact of orthopedic plates on peripheral nerve stimulation (PNS) during MRI, focusing how presence implants affects PNS thresholds. Methods A combination anatomical electromagnetic and neurophysiological modeling was utilized. Electromagnetic fields in human body models were simulated, both with without plates. Simulations performed under x ‐, y z ‐axis gradient coils, implanted at two clinically relevant locations. Nerve responses modeled using...
Graft-versus-host disease (GVHD) and relapse are major complications following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Metabolites play crucial roles in immune regulation, but their causal relationships with GVHD remain unclear. We utilized genetic variants from genome-wide association studies (GWAS) of 309 known metabolites as instrumental variables to evaluate effects on acute (aGVHD), gut GVHD, chronic (cGVHD), different populations. Multiple inference methods,...
Ansamitocin P-3 (AP-3) is a promising anticancer agent. However, its low solubility has limited biomedical applications. The preparation of liposomal formulations for the delivery drugs using microfluidic platform attracted increasing attention in pharmaceutical industry. In addition, photodynamic therapy (PDT) non-invasive and efficient strategy treatment cancers, making liposomes one most drug systems (DDSs). this study, recently developed device (swirl mixer) was used manufacturing...
The objective was to evaluate the utility of urinary 1-hydroxypyrene (1-OHP), S-phenylmercapturic acid (S-PMA), trans,trans-muconic (t,t-MA), 3-methyladenine (3-MeAd), 3-ethyladenine (3-EtAd), 8-hydroxy-2′-deoxyguanosine (8-OHdG) and thioethers as biomarkers for assessing exposure in adult smokers who switched from smoking conventional cigarettes candidate potential reduced products (PREP) or stopped smoking. Two electrically heated systems (EHCSS) were used prototype that have significant...
Journal Article Evaluation of biomarkers exposure in adult cigarette smokers using Marlboro Snus Get access Mohamadi Sarkar, Sarkar Search for other works by this author on: Oxford Academic PubMed Google Scholar Jianmin Liu, Liu Tamara Koval, Koval Jingzhu Wang, Wang Shixia Feng, Feng Richard Serafin, Serafin Yan Jin, Jin Yuli Xie, Xie Kirk Newland, Newland Hans J. Roethig Nicotine & Tobacco Research, Volume 12, Issue 2, February 2010, Pages 105–116, https://doi.org/10.1093/ntr/ntp183...
Objective: FL058 is a novel beta-lactamase inhibitor with broad spectrum of activity and favorable safety profile. The objective this study was to evaluate pharmacokinetic/pharmacodynamic (PK/PD) relationships for the combination meropenem in an vitro infection model. Methods: By simulating human concentration-time profiles model, combined when administered 1 g/0.5 g, g/1 2 g/2 g q8h by 3-h infusion achieved approximately 2- 4-log10 kill KPC/OXA-producing Klebsiella pneumoniae Escherichia...
Abstract Obstructive hypertrophic cardiomyopathy (oHCM) is a subtype of HCM characterized by left ventricular outflow tract obstruction resulting from cardiac muscle hypertrophy and anatomic alterations in the mitral valve apparatus. Mavacamten, myosin inhibitor metabolized primarily CYP2C19 liver, first only targeted medication approved for treatment symptomatic New York Heart Association (NYHA) class II–III oHCM. Previous pharmacokinetic (PK) results mavacamten healthy Caucasian, Japanese,...
Introduction Clinical observations have found that prolonged use of analgesics increases the incidence infection. However, direct causal relationship between prescription analgesic (PAU) and risk infection (ROI) remains unclear. Methods This study used Mendelian randomization (MR) design to estimate effect PAU on ROI, as well their mediating factors. Genetic data immune cells were obtained from published GWAS. Additionally, ROI extracted FinnGen database. Two-sample MR analysis multivariate...
ABSTRACT FL058 is a novel diazabicyclooctane β-lactamase inhibitor. This first-in-human study evaluated the safety, tolerability, and population pharmacokinetic (PK)/pharmacodynamic target attainment analysis of alone in combination with meropenem healthy subjects. The results showed that maximum tolerated dose was 3,000 mg after single-dose infusion. did not cause any grade 3 or higher adverse event when escalated up to 1,000 mg/2,000 mg. exposure PK parameters proportionality. excreted...
Background: Chaperonin-containing TCP1 subunit 8 (CCT8) has been proved to be involved in the occurrence and development of some cancers. However, no study reported potential role CCT8 a pan-cancer manner. Methods: TIMER2.0, GEPIA2, UALCAN Sangerbox were used explore expression, prognosis methylation CCT8. We cBioPortal, TISIDB, SangerBox, TIMER2.0 TISMO investigate genetic alteration relationship with molecular subtype, immune infiltration immunotherapy response. CCT8-related genes screened...
ABSTRACT Contezolid acefosamil (also known as MRX-4), a prodrug of contezolid, is under development for treatment multidrug-resistant Gram-positive bacterial infections. A phase I single ascending dose (SAD) and multiple-dose placebo-controlled study was conducted to assess the safety, tolerability, pharmacokinetics (PK) contezolid in healthy Chinese subjects following intravenous (IV) oral administration. Adverse events (AEs) PK parameters were assessed appropriately. All ( n = 70)...
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) significantly improve the survival of patients with (EGFR) sensitive mutations in non-small cell lung cancer (NSCLC).
Objective To investigate the diagnostic value of metagenomic next-generation sequencing (mNGS) in detecting pathogens from joint infection (JI) synovial fluid (SF) samples with previous antibiotic exposure. Methods From January 2019 to 2022, 59 cases suspected JI were enrolled. All had exposure within 2 weeks before sample collection. mNGS and conventional culture performed on SF samples. was diagnosed based history clinical symptoms conjunction MSIS criteria. The values, including...
Studying the impact of local meteorological conditions and air pollution on cardiovascular disease is crucial for reducing burden disease. However, there have been few studies acute effects various pollutants stable ischemic heart (SIHD), these factors are not well defined require further investigation. We performed a time-series study aimed at exploring association between short-term exposure to emergency department (ED) visits SIHD during 2013-2020 in Baoshan District Renhe Hospital...
Objective This retrospective multicentre observational study was performed to assess the predictors of acute kidney injury (AKI) in patients with decompensated heart failure (ADHF) emergency departments China. Methods In total, 1743 consecutive ADHF were recruited from August 2017 January 2018. Clinical characteristics and outcomes compared between without AKI. Predictors AKI occurrence underdiagnosis assessed multivariate regression analyses. Results Of patients, 593 (34.0%) had partly...
Th17 cells are powerful inflammation promoters in the pathogenesis of abdominal aortic aneurysms (AAAs). Myeloid-derived suppressor (MDSCs) can promote differentiation chronic inflammatory autoimmune injury. Here, we aim to examine whether MDSCs regulate participate development AAA. We demonstrated an abnormal accumulation AAA patients, which was positively associated with cells. established angiotensin II-induced apolipoprotein E knockout mice and found impaired immunosuppressive function...
Experimental section, 1 H and 13 C NMR spectra of prepared compounds Table contents 1. Optimization reaction conditions