A5014393752- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- Antimicrobial Resistance in Staphylococcus
- Biosimilars and Bioanalytical Methods
- Bacterial Infections and Vaccines
- Ginseng Biological Effects and Applications
- Analytical Methods in Pharmaceuticals
- Toxin Mechanisms and Immunotoxins
- Liver Disease Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Monoclonal and Polyclonal Antibodies Research
- Clostridium difficile and Clostridium perfringens research
- Metabolomics and Mass Spectrometry Studies
- Bacterial Identification and Susceptibility Testing
- Microfluidic and Capillary Electrophoresis Applications
- COVID-19 Clinical Research Studies
- Pharmaceutical studies and practices
- SARS-CoV-2 and COVID-19 Research
- Phenothiazines and Benzothiazines Synthesis and Activities
- Antifungal resistance and susceptibility
- Respiratory viral infections research
- Adipose Tissue and Metabolism
- Cell Adhesion Molecules Research
- Veterinary medicine and infectious diseases
Huashan Hospital
2016-2025
Fudan University
2016-2025
National Health and Family Planning Commission
2014-2024
Shenzhen University
2024
Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality
2024
Shandong Normal University
2024
Shanghai Clinical Research Center
2024
Soochow University
2022
First Affiliated Hospital of Soochow University
2022
Binzhou People's Hospital
2020-2021
Objective Impaired hepatic fatty acids oxidation results in lipid accumulation and redox imbalance, promoting the development of liver diseases insulin resistance. However, underlying pathogenic mechanism is poorly understood. Krüppel-like factor 16 (KLF16) a transcription that abounds liver. We explored whether by what mechanisms KLF16 affects catabolism to improve hepatosteatosis Design expression was determined patients with non-alcoholic disease (NAFLD) mice models. The role regulation...
Ginsenoside Rg2 has been previously reported to reduce glucose production and adipogenesis in adipose tissue. However, the effects of ginsenosides on hepatic lipid metabolism remain vacant. In this study, we found that ginsenoside treatment significantly attenuated oleic acid palmitic (OA&PA)-induced intracellular deposition oxidative stress mouse primary hepatocytes. C57BL/6J mice are fed with a high-fat diet (HFD) treated displayed decreased body weight, reversed steatosis, improved...
434420 Background: Claudin 18.2 (CLDN18.2) is a promising therapeutic target for advanced gastric/gastroesophageal junction (G/GEJ) cancer. CMG901, potential first-in-class CLDN18.2-targeted antibody-drug conjugate carrying monomethyl auristatin E (MMAE), has demonstrated potent anti-tumor activity in preclinical studies. Methods: This phase 1 trial included dose-escalation (part A; 0.3-3.4 mg/kg) and dose-expansion B; 2.2, 2.6, 3.0 to evaluate safety, tolerability, of CMG901 patients (pts)...
Meropenem is used to manage postneurosurgical meningitis, but its population pharmacokinetics (PPK) in plasma and cerebrospinal fluid (CSF) this patient group are not well-known. Our aims were (i) characterize meropenem PPK CSF (ii) recommend favorable dosing regimens meningitis patients. Eighty-two patients enrolled receive infusions of 2 g every 8 h (q8h), 1 q8h, or q6h for at least 3 days. Serial blood samples collected, concentrations determined analyzed via modeling. Probabilities...
Objective: FL058 is a novel beta-lactamase inhibitor with broad spectrum of activity and favorable safety profile. The objective this study was to evaluate pharmacokinetic/pharmacodynamic (PK/PD) relationships for the combination meropenem in an vitro infection model. Methods: By simulating human concentration-time profiles model, combined when administered 1 g/0.5 g, g/1 2 g/2 g q8h by 3-h infusion achieved approximately 2- 4-log10 kill KPC/OXA-producing Klebsiella pneumoniae Escherichia...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread rapidly worldwide. This study is the first report tolerability, safety, pharmacokinetics (PK), and immunogenicity of a recombinant human anti-SARS-CoV-2 monoclonal antibody, etesevimab (CB6, JS016, LY3832479, or LY-CoV016), in healthy adults. paper describes randomized, double-blind, placebo-controlled, phase 1 study. A total 40 participants were enrolled receive single intravenous dose either placebo one four...
ABSTRACT The aim of this paper was to investigate the pharmacokinetics (PK) and pharmacodynamics (PD) nemonoxacin, a novel nonfluorinated quinolone, against Streptococcus pneumoniae in vitro . A modified infection model used simulate nemonoxacin following scaling single oral doses multiple dosing. Four S. strains with different penicillin sensitivities were selected, drug efficacy quantified by change log colony counts within 24 h. sigmoid maximum-effect ( E max ) analyze relationship...
Hepatic lipid disorder impaired mitochondrial homeostasis and intracellular redox balance, triggering development of non-alcohol fatty liver disease (NAFLD), while effective therapeutic approach remains inadequate. Ginsenosides Rc has been reported to maintain glucose balance in adipose tissue, its role regulating metabolism remain vacant. Thus, we investigated the function mechanism ginsenosides defending high fat diet (HFD)-induced NAFLD. Mice primary hepatocytes (MPHs) challenged with...
What is known and objective The pharmacokinetics (PK) pharmacodynamics (PD) of levofloxacin were investigated following administration injection in healthy Chinese volunteers for optimizing dosing regimen. Methods PK study included single-dose (750 mg/150 mL) multiple-dose mL once daily 7 days) phases. concentration blood urine was determined using HPLC method. Both non-compartmental compartmental analyses performed to estimate parameters. Taking fCmax/MIC ≥5 fAUC24 h/MIC ≥30 as a target,...
Contezolid (MRX-I), a new oxazolidinone, is an antibiotic in development for treating complicated skin and soft tissue infections caused by resistant Gram-positive bacteria. This was thorough QT study conducted 52 healthy subjects who were administered oral contezolid at therapeutic (800 mg) dose, supratherapeutic (1,600 placebo, moxifloxacin 400 mg four separate treatment periods. The pharmacokinetic profile of also evaluated. Time point analysis indicated that the upper bounds two-sided...
Background: At present, few studies have reported the metabolic profiles of lung tissue in patients with COPD. Our study attempted to analyze metabolome male COPD and screen overlapping biomarkers plasma metabolomes. Methods: We performed untargeted metabolomic analysis normal from two independent sets (the discovery set: 20 controls replication 47 27 controls) samples 80 subjects containing 40 controls. Results: found glycerophospholipids (GPs) Amino acids were primary classes differential...
Abstract Objective The present study was performed to explore dosing regimens of colistin in patients cystic fibrosis (CF) with Pseudomonas aeruginosa chronic biofilm lung infection. Methods Ten CF were involved. One dose colistimethate sodium (CMS) 6 MIU (million international units) and 9 administered by intravenous infusion over 45 90 min. Venous blood collected at different time points after the CMS. Pharmacokinetic parameters calculated. Minimum inhibitory concentration for planktonic...