A5063213269- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Tryptophan and brain disorders
- Clostridium difficile and Clostridium perfringens research
- Neuroendocrine regulation and behavior
- Phytoestrogen effects and research
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Microbial Metabolites in Food Biotechnology
- Ginseng Biological Effects and Applications
- Liver Disease Diagnosis and Treatment
- Probiotics and Fermented Foods
Hefei University of Technology
2022-2024
China Agricultural University
2024
Xuzhou Medical College
2020-2023
Obesity is a risk factor for neurodegenerative disease associated with cognitive dysfunction, including Alzheimer's disease. Low-grade inflammation common in obesity, but the mechanism between and impairment obesity unclear. Accumulative evidence shows that quinolinic acid (QA), neuroinflammatory neurotoxin, involved pathogenesis of processes. We investigated role QA obesity-induced beneficial effect butyrate counteracting impairments cognition, neural morphology, signaling. show human there...
Abstract Current treatment for functional dyspepsia (FD) has limited and unsustainable efficacy. Probiotics have the sustainable potential to alleviate FD. This randomized controlled clinical trial (Chinese Clinical Trial Registry, ChiCTR2000041430) assigned 200 FD patients receive placebo, positive-drug (rabeprazole), or Bifidobacterium animalis subsp . lactis BL-99 (BL-99; low, high doses) 8-week. The primary outcome was response rate (CRR) of score after 8-week treatment. secondary...
The microbiota–gut–liver axis has emerged as an important player in developing nonalcoholic steatohepatitis (NASH), a type of fatty liver disease (NAFLD). Higher mushroom intake is negatively associated with the prevalence NAFLD. This study examined whether lentinan, active ingredient mushrooms, could improve NAFLD and gut microbiota dysbiosis mice induced by high-fat (HF) diet. Dietary lentinan supplementation for 15 weeks significantly improved HF mice, evidenced increased abundance phylum...
High-fat (HF) diet-induced neuroinflammation and cognitive decline in humans animals have been associated with microbiota dysbiosis via the gut-brain axis. Our previous studies revealed that excretory-secretory products (ESPs) derived from larval Echinococcus granulosus ( E. ) function as immunomodulators to reduce inflammatory response, while parasitic infection alleviates metabolic disorders host. However, whether ESPs can improve impairment under obese conditions remain unknown. This...
Probiotics are live microorganisms with immunomodulatory effects in a strain-specific and dose-dependent manner.
Hepatic lipid disorder impaired mitochondrial homeostasis and intracellular redox balance, triggering development of non-alcohol fatty liver disease (NAFLD), while effective therapeutic approach remains inadequate. Ginsenosides Rc has been reported to maintain glucose balance in adipose tissue, its role regulating metabolism remain vacant. Thus, we investigated the function mechanism ginsenosides defending high fat diet (HFD)-induced NAFLD. Mice primary hepatocytes (MPHs) challenged with...
<title>Abstract</title> Functional dyspepsia (FD) is a common chronic gastrointestinal disorder without known organic pathology changes. Recurrence symptoms and longer duration resulting in poor quality of life high medical expenses for patients. Therefore, searching prolonged treatment FD has considerable clinical value. This research aims at determining the efficacy <italic>Bifidobacterium lactis</italic> BL-99 (BL-99) improving gut microbiota promoting digestion patients with functional...
Abstract Background Current treatment for functional dyspepsia (FD) has limited and unsustainable efficacy. Probiotics have the potential to alleviate FD; However, underlying mechanism remains unclear. This study aimed evaluate effect of probiotics in alleviating FD. Methods A randomized, positive-drug placebo-controlled clinical trial was conducted; 200 FD patients were randomly divided into four groups (placebo, positive control [proton pump inhibitors, PPI] or Bifidobacterium lactis BL-99...
Background: Current treatment for functional dyspepsia (FD) has limited and unsustainable efficacy. Probiotics have the potential to alleviate FD; However, underlying mechanism remains unclear. This study aimed evaluate effect of probiotics in alleviating FD.Methods: A randomized, positive-drug, placebo-controlled clinical trial was conducted at Beijing Chaoyang Hospital, Capital Medical University; Patients with FD (18-60 years, defined according Rome IV criteria) were randomly divided into...