A5091782508- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Pulmonary Hypertension Research and Treatments
- Telomeres, Telomerase, and Senescence
- Genomics, phytochemicals, and oxidative stress
- Sarcoidosis and Beryllium Toxicity Research
- Ion Channels and Receptors
- Epigenetics and DNA Methylation
- Asthma and respiratory diseases
- Phosphorus and nutrient management
- Sepsis Diagnosis and Treatment
- Air Quality and Health Impacts
- Autophagy in Disease and Therapy
- Pregnancy-related medical research
- Kruppel-like factors research
- Thermal Regulation in Medicine
- Occupational and environmental lung diseases
- Hydrogen's biological and therapeutic effects
- Pneumocystis jirovecii pneumonia detection and treatment
- Cardiovascular Function and Risk Factors
- Respiratory and Cough-Related Research
- Health Promotion and Cardiovascular Prevention
Huazhong University of Science and Technology
2020-2025
Tongji Hospital
2020-2025
Chronic obstructive pulmonary disease (COPD) is a heterogeneous typically characterized by chronic airway inflammation, with emerging evidence highlighting the driving role of cellular senescence-related lung aging. Accelerated aging and inflammation mutually reinforce each other, creating detrimental cycle that contributes to progression. Growth arrest DNA damage-inducible (GADD45) family has been reported involve in multiple biological processes, including senescence. However, GADD45 COPD...
Idiopathic pulmonary fibrosis (IPF) is characterized by excessive fibroblast recruitment and persistent extracellular matrix deposition at sites of tissue injury, leading to severe morbidity mortality. However, the precise mechanisms which fibroblasts contribute IPF pathogenesis remain poorly understood. The study reveals that Sema3E its receptor Plexin D1 are significantly overexpressed in lungs patients bleomycin (BLM)-induced lung fibrotic mice. Elevated plasma levels negatively...
Abstract To evaluate the efficacy of corticosteroids on coronavirus disease 2019 (COVID‐19) patients with different levels severity. In our multicenter study, 543 confirmed COVID‐19 were classified as non‐severe group and severe group, then compared respectively for all‐cause mortality length hospital stay between those who received not. By searching in PubMed, Web Science, Embase, CNKI, we identified 13 retrospective studies 6 random control trials eligible criteria inclusion, conducted...
Chronic obstructive pulmonary disease (COPD) is a progressive characterized by chronic inflammation and airway remodeling. Human epididymis protein 4 (HE4) plays critical role in various inflammatory or fibrotic diseases. However, the of HE4 COPD remains unidentified.HE4 expression was determined lung tissues from patients cigarette smoke (CS)-exposed mice using immunohistochemical staining, qPCR, western blot. The plasma level detected ELISA. regulations expressions CS extract (CSE)-induced...
Background: Since December 2019, COVID-19 has emerged in Wuhan, China and spread rapidly throughout China. So far, there is still no explicit therapeutic regimen or specific drugs. Methods: In this retrospective, multi-center study, we extracted the clinical data on 416 cases of with definite outcome from 14 hospitals Hubei province, evaluated characteristics treatment regimens. Outcomes were followed up until Feb 17, 2020. Finding: Fifty-one patients had died. Dead a higher median age 67·0...
Because only a small portion of NSCLC (non-small-cell lung cancer) patients benefit from molecular targeted therapy or immunotherapy and do not develop therapeutic resistance, continued research on new targets is warranted. Serotonin has recently emerged as growth factor for tumor cells, its receptors may be potential targets. The mechanism related to the behavior 5-HT7 receptor in remains unknown.Both gene expression analysis immunohistochemical were conducted evaluate tissues. correlation...
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory of the airways characterized by impaired lung function induced cigarette smoke (CS). Reduced DACH1 (dachshund homolog 1) expression has detrimental role in numerous disorders, but its COPD remains understudied. This study aimed to elucidate and underlying mechanism airway inflammation measuring tissues patients with COPD. Airway epithelium-specific DACH1-knockdown mice adenoassociated virus-transfected...
Background: At present, few studies have reported the metabolic profiles of lung tissue in patients with COPD. Our study attempted to analyze metabolome male COPD and screen overlapping biomarkers plasma metabolomes. Methods: We performed untargeted metabolomic analysis normal from two independent sets (the discovery set: 20 controls replication 47 27 controls) samples 80 subjects containing 40 controls. Results: found glycerophospholipids (GPs) Amino acids were primary classes differential...
Chronic obstructive pulmonary disease (COPD), primarily attributed to cigarette smoke (CS), is characterized by multiple pathophysiological changes, including oxidative stress and inflammation. Stromal interaction molecule 1 (STIM1) a Ca 2+ sensor that regulates entry in different types of cells. The present study aimed explore the relationship between CS-induced inflammation, as well functional role STIM1 thereinto. Our results showed reactive oxygen species (ROS)/STIM1/Ca axis played...
Extensive inflammation and apoptosis in structural cells of the lung are responsible for progression pathogenesis chronic obstructive pulmonary disease (COPD). Myotubularin-related protein 14 (MTMR14) has been shown to participate various biological processes, including apoptosis, inflammation, autophagy. Nonetheless, role MTMR14 COPD remains elusive. In present study, we explored expression human tissues investigated effects overexpressed on vitro vivo models. Moreover, one possible...
Objective: To study the characteristics of patients hospitalized for asthma exacerbation in 29 teaching hospitals China and to evaluate hospitalization costs these patients. Methods: This was a retrospective involved throughout during 2013-2014. Information about demographic features, conditions before admission, outcome, complications, collected using pre-designed case report form. The influencing factors were analyzed. Results: 3 240 asthmatic (1 369 males 1 871 females) included data...
Chronic obstructive pulmonary disease (COPD) is composed of chronic airway inflammation and emphysema. Recent studies show that Class IA phosphatidylinositol 3-kinases (PI3Ks) play an important role in the regulation However, there are few on their regulatory subunits. p55PIK a subunit PI3Ks, its unique NH 2 -terminal gives it special functions. expression lungs nonsmokers, smokers, patients with COPD was examined. We established fusion protein TAT-N15 from effector sequence TAT (the...
Chronic obstructive pulmonary disease (COPD), a small airway disease, is regarded as metabolic disorder. To further uncover the profile of COPD patients, it necessary to identify metabolism-related differential genes in epithelium (SAE) COPD. Metabolism-related SAE between patients and nonsmokers were screened from GSE128708 GSE20257 datasets. KEGG, GO, PPI analyses performed evaluate pathway enrichment, term protein interaction candidate genes, respectively. RT-PCR was used verify mRNA...
Pulmonary hypertension (PH) is a chronic vascular proliferative disorder. While cigarette smoke (CS) plays vital part in PH related to obstructive pulmonary disease (COPD). Methyl-CpG-Binding Domain Protein 2 (MBD2) has been linked multiple diseases. However, the specific mechanisms of MBD2 CS-induced remain be elucidated. Herein, differential expression was tested between controls and patients’ arteries, CS-exposed rat models’ primary human artery smooth muscle cells (HPASMCs) following...
Aging plays an essential role in the development for chronic obstructive pulmonary disease (COPD). The aim of this study was to identify and validate potential aging-related genes COPD through bioinformatics analysis experimental validation. Firstly, we compared gene expression profiles aged young patients using two datasets (GSE76925 GSE47460) from Gene Expression Omnibus (GEO), identified 244 different expressed (DEGs), with 132 up-regulated 112 down-regulated. Then, by analyzing data...
Abstract Background Previous studies have observed the abnormality in telomere biology and function during process of chronic lung diseases (CLDs). However, whether alteration length (TL) causally facilitates incidence CLDs remains to be determined. Therefore, we here aim estimate causal effect TL on risk using mendelian randomization (MR) analysis. Methods Single nucleotide polymorphisms (SNPs) strongly associated with were selected as genetic variables from genome-wide association (GWAS)....
Background: Chronic obstructive pulmonary disease (COPD) is a heterogeneous typically characterized by chronic airway inflammation, with emerging evidence highlighting the driving role of cellular senescence-related lung aging. Growth arrest and DNA damage-inducible (GADD45) family has been reported to involve in multiple biological processes, including inflammation senescence. However, GADD45 COPD remains elusive.Methods: Expressions were evaluated bioinformatic analysis combined detections...
Abstract Background Since December 2019, COVID-19 has emerged in Wuhan, China and spread globally. As of now, there is still no explicit therapeutic regimen the use corticosteroid also controversial. We aimed to explore effectiveness provide evidence for rational different patients with COVID-19.Methods In this multi-centered, retrospective study, we extracted clinical data 649 cases definite outcome (discharged or dead) from 14 hospitals Hubei province, evaluated characteristics, treatment...
<title>Abstract</title> <bold>Background: </bold>Chronic obstructive pulmonary disease (COPD)is a small airway chronic inflammatory with impaired lung function primarily induced by cigarette smoke (CS). Reduced Dach1 expression has vicious role in numerous disorders. but its COPD is rarely known. This study aims to elucidate the and underlying mechanism of inflammation COPD. <bold>Methods:</bold>Dach1 tissues patients been calculated. Small epithelium-specific knockdown mice AAV-transfected...