Unintended intake of microplastic particles has been demonstrated to exert adverse health effects, however, studies on relevant nephrotoxicity in juvenile mammals are lacking.Therefore, we investigated the potential oral-exposed polystyrene microplastics (PSMPs) (1,000 nm, 2.0 mg/kg/d) for 28 days rats. Levels oxidative stress, inflammation, and endoplasmic reticulum (ER) stress kidneys were analyzed.Results revealed that PSMPs noticeably decreased growth rate bodyweight, organ index kidney,...

Anti-tumor immunity through checkpoint inhibitors, specifically anti-programmed death 1 (PD-1)/programmed ligand (PD-L1) interaction, is a promising approach for cancer therapy. However, as early clinical trials indicate that colorectal cancers (CRCs) do not respond well to immune-checkpoint therapies, new effective immunotherapy approaches CRC warrant further study. Simvastatin an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (CoA) reductase (HMGCR), the rate-limiting enzyme mevalonate...

Generally, individual microplastics (MPs) or lead (Pb) exposure could initiate ovarian toxicity. However, their combined effects on the ovary and its mechanism in mammals remained unclear. Female C57BL/6 mice were used this study to investigate toxicity of polystyrene MPs (PS-MPs, 0.1 mg/d/mouse) Pb (1 g/L) for 28 days. Results showed that co-exposure PS-MPs increased accumulation ovaries, histopathological damage ovaries uterus, serum malondialdehyde levels decreased superoxide dismutase...

Tumor-infiltrating lymphocytes (TILs) are clinically significant in triple-negative breast cancer (TNBC). Although a standardized methodology for visual TILs assessment (VTA) exists, it has several inherent limitations. We established deep learning-based computational TIL (CTA) method broadly following VTA guideline and compared with TNBC to determine the prognostic value of CTA reasonable workflow clinical practice.We trained three neural networks nuclei segmentation, classification...

Background: Consensus is lacking with regard to whether hearing loss an independent risk factor for dementia. We therefore conducted a meta-analysis clarify the relationship of and Methods: Prospective cohort studies investigating association between incidence dementia in community-derived population were included by searching electronic databases that PubMed, Embase, Cochrane's Library. A random-effects model was adopted combine results. Results: Fourteen cohorts including 726,900...

Ovarian cancer is the seventh most common in women and second reason of gynecologic cancer-related death. Growing evidence showed that exosomal miRNA plays a crucial role progression ovarian cancer.Exosomes were identified using nanoparticle tracking analysis, transmission electron microscopy marker proteins detection. The levels mRNA ensured by qRT-PCR western blot, respectively. Immunofluorescence, flow cytometry ELISA assay carried out to analyze macrophages polarization. CCK-8 Transwell...

Numerous reports confirm that microplastics exposure could induce reproductive toxicity in mammals. However, the effects of during juveniles on ovarian apoptosis through oxidative and endoplasmic reticulum (ER) stresses remains unclear, which is focus our study. In present study, female rats (4 weeks old) were exposed to polystyrene (PS-MPs, 1 μm) at different dosages (0, 0.5, 2.0 mg/kg) for 28 days. Findings revealed mg/kg PS-MPs distinctly increased atretic follicle ratio ovary...

Chronic inflammation is a common complication in peritoneal dialysis (PD) patients. The aim of this study to investigate the capacity aggregate index systemic (AISI), immune-inflammation (SII), and response (SIRI) predict all-cause mortality PD patients.This was single-center retrospective study. optimal cutoff values were identified by receiver operating characteristic (ROC) curve analysis. area under (AUC) calculated evaluate predictive ability these indexes. Kaplan-Meier curves log-rank...

Abstract Premature ovarian failure (POF) is a leading cause of women’s infertility without effective treatment. The purpose this study was to investigate the protective effects Luffa cylindrica fermentation liquid (LF) on cyclophosphamide (CTX) -induced POF in mice and preliminarily underlying mechanisms. Thirty-two Balb/c were divided into four groups randomly. One group served as control, while other three received CTX injections establish models. A 14-day gavage either 5 or 10 μL/g LF...

<sec> <title>BACKGROUND</title> Due to compromised immune systems, people living with HIV/AIDS (PLWHA) are at an increased risk of opportunistic infections and deaths. </sec> <title>OBJECTIVE</title> The aim this study was develop spatial externally validate a predictive model for the survival PLWHA following initiation highly active anti-retroviral therapy (HAART) in China. <title>METHODS</title> This retrospective cohort used data from epidemic surveillance system National Center AIDS/STD...

To analyze the transmission characteristics of newly reported HIV-infected students aged ≥18 years in Nanjing City from 2016 to 2022 and provide evidence for AIDS publicity intervention among young students. The pol region sequences non-student individuals were collected, BLAST tool was used search published global non-Nanjing HIV infection LANL database. basic molecular network regional constructed using HIV-TRACE a pairwise genetic distance threshold 1.0%. 332 infected aged≥18 City, 1 904...

Neurodegenerative comorbidities are common and critical, yet data specific to the Chinese population remains limited. The study aims investigate prevalence associations of neuropathologic changes comorbidities, their correlation with genetics cognition in a community-dwelling autopsy cohort China. Datasets 610 participants were obtained from National Human Brain Bank for Development Function at Academy Medical Sciences/Peking Union College. Neuropathological analysed included Alzheimer's...

Mpox is a zoonotic disease caused by the mpox virus (MPXV), which has recently exhibited human-to-human transmission globally. Due to its hidden nature and high-risk behaviors, men who have sex with (MSM) become focal point for prevention control. This study evaluates impact of health interventions on knowledge awareness among MSM. Through pre- post-MIP surveys, we analyzed knowledge, preferences acquiring information, preferred channels Data collection occurred from August 2023 March 2024,...

The mortality and disability rates among severely injured trauma patients are very high. This study aimed to investigate whether a new in-hospital care model can improve emergency efficiency enhance the prognosis of patients. retrospective observational included 366 (ISS ≥ 16) who were admitted department tertiary hospital between 2023 2024. Based on used, divided into traditional group (n = 213) from January April 153) general clinical data, information, as well seven quality control...

Aminopeptidase N (EC 3.4.11.2) is an important enzyme that involved in the degradation of regulatory peptides including enkephalins. We report here purified and native membrane-bound aminopeptidase will sequentially completely hydrolyze both Leu-enkephalin Met-enkephalin from amino terminus. Both pig on live HL60 cells displayed similar Km values for enkephalin. The naturally occurring neuropeptides substance P bradykinin, morphine agonist, morphiceptin, were not hydrolyzed by each inhibited...

Transmitted drug resistance (TDR) is an increasingly prevalent problem worldwide, which will significantly compromise the effectiveness of HIV treatments. However, in Nanjing, China, there still a dearth research on prevalence and transmission TDR among ART-naïve HIV-1-infected individuals. This study aimed to understand Nanjing. A total 1,393 participants who were newly diagnosed with HIV-1 had not received ART between January 2019 December 2021 enrolled this study. pol gene sequence was...

A large number of men who have sex with (MSM) and people living HIV/AIDS (PLHA) are underserved despite increased service availability from government facilities while many community based organizations (CBOs) not involved. We aimed to assess the feasibility effectiveness task shifting CBOs in China.HIV preventive intervention for MSM follow-up care PLHA were shifted CBOs. Based on 'cash delivery' model, 10 USD per tested HIV results notified, 82 newly cases diagnosed, 50 received a defined...

Abstract Background We retrospectively compared the prognostic value between AJCC 8th edition anatomic (AS) and staging (PS) system for triple negative breast cancer (TNBC) in a cohort from two involved institutions large population database. Methods Clinicopathological data of TNBCs were identified (SYSUCC-PWH cohort). Data SEER database during 2010–2015 was also accessed. restaged all cases into AS PS group according to system. Results A total 611 31,941 cohorts, with median follow-up 53.5...

The monocyte-to-lymphocyte ratio (MLR) is considered as a new inflammation marker. This study was aimed to investigate the prognostic value of MLR for all-cause mortality and new-onset cardiovascular disease (CVD) events in peritoneal dialysis (PD) patients.This enrolled patients receiving PD treatment ≥ 3 months. Baseline characteristics were obtained within 1 week before catheterization. receiver operating characteristic curve analysis conducted determine optimal cut-off MLR. Kaplan-Meier...

Abstract Objective The objective of this study was to conduct a comprehensive analysis the molecular transmission networks and transmitted drug resistance (TDR) patterns among individuals newly diagnosed with HIV-1 in Nanjing. Methods Plasma samples were collected from HIV patients Nanjing between 2019 2021. pol gene amplified, resulting sequences utilized for determining TDR, identifying viral subtypes, constructing network. Logistic regression analyses employed investigate epidemiological...

Objectives A lower relative handgrip strength (HGS) may disrupt metabolic homeostasis and then lead to syndrome (MetS). There is a paucity of longitudinal studies examine whether HGS at baseline linked incident MetS. Thus, the purpose present study was explore association between new-onset Design This an observational research. nationally representative sample population in China. Participants total 3350 subjects without MetS were selected for analysis study. Data are from China Health...

We investigated the regulation of Na + and K excretion epithelial channel (ENaC) in mice lacking gene for aldosterone synthase (AS) using clearance methods to assess electrophysiology Western blot analysis test ENaC activity processing. After 1 day dietary restriction, AS −/− lost more urine than +/+ did. wk on this diet, both genotypes strongly reduced urinary excretion, but creatinine decreased only mice. Only animals exhibited increased function, assessed as amiloride-sensitive whole cell...

Background Coronary atherosclerosis diseases (CADs) are associated with chronic inflammation. Neutrophil extracellular traps (NETs) a type of novel proinflammatory cytokines whose levels dramatically elevated in acute coronary syndrome. We conducted this study to further evaluate the association between circulating NET-associated markers and CAD Chinese adults. Methods A total 174 patients 55 healthy controls were screened using percutaneous intervention or computed tomography angiography....