A5100353845- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- Hearing, Cochlea, Tinnitus, Genetics
- HIV/AIDS drug development and treatment
- HIV, TB, and STIs Epidemiology
- Bat Biology and Ecology Studies
- Hearing Loss and Rehabilitation
- Biochemical Analysis and Sensing Techniques
- Noise Effects and Management
- Nutrition, Genetics, and Disease
- Pneumocystis jirovecii pneumonia detection and treatment
- Calcium signaling and nucleotide metabolism
- Adolescent Sexual and Reproductive Health
- Genetic Mapping and Diversity in Plants and Animals
- Cellular transport and secretion
- Cardiovascular Health and Risk Factors
Nanjing Municipal Center for Disease Control And Prevention
2017-2024
Yunnan Center for Disease Control And Prevention
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2017
Chongqing Medical University
2017
University of Southern California
2015
House Clinic
2014-2015
First Affiliated Hospital of Nanchang University
2015
Nanchang University
2015
Abstract Objective The objective of this study was to conduct a comprehensive analysis the molecular transmission networks and transmitted drug resistance (TDR) patterns among individuals newly diagnosed with HIV-1 in Nanjing. Methods Plasma samples were collected from HIV patients Nanjing between 2019 2021. pol gene amplified, resulting sequences utilized for determining TDR, identifying viral subtypes, constructing network. Logistic regression analyses employed investigate epidemiological...
Abstract Genome-wide association studies (GWAS) have been successfully applied in humans for the study of many complex phenotypes. However, identification genetic determinants hearing adults has hampered, part, by relative inability to control environmental factors that might affect throughout lifetime, as well a large degree phenotypic heterogeneity. These and other limited number large-scale performed identified candidate genes contribute etiology this trait. To address these limitations,...
Background The HIV-1 molecular network is an innovative tool, using gene sequences to understand transmission attributes and complementing social sexual studies. While previous research focused on static characteristics, recent studies’ emphasis dynamic features enhances our understanding of real-time changes, offering insights for targeted interventions efficient allocation public health resources. Objective This study aims identify the changes occurring in networks analyze primary...
The hybrid mouse diversity panel (HMDP), a of 100 strains, has been employed in genome wide association studies (GWAS) to study complex traits mice. Hearing is trait and the CBA/CaJ strain widely used model for age-related hearing loss (ARHI) noise induced (NIHL). strain's youthful sensitivity limited led us attempt identify additional strains segregating similar phenotype our panel. FVB/NJ part HMDP previously described as having ARHI CBA/CaJ. For these reasons, we have studied NIHL...
The growing HIV epidemic among student men who have sex with (MSM) necessitates immediate attention from public health. In China, male students (SMSM) were also at an increasing risk of transmission. aim this study was to investigate the trends in prevalence, HIV-related behaviors, and testing, as well analyze factors associated infection SMSM Nanjing.Data collected through face-to-face questionnaire interviews laboratory testing Nanjing. participants recruited by snowball sampling...
Usher syndrome (USH) is an autosomal recessive disease characterized by deafness and retinitis pigmentosa. In view of the high phenotypic genetic heterogeneity in USH, performing screening with traditional methods impractical. present study, we carried out targeted next-generation sequencing (NGS) to uncover underlying gene USH family (2 patients 15 unaffected relatives). One hundred thirty-five genes associated inherited retinal degeneration were selected for deep exome sequencing....
Objective: To investigate the situation of recreational drug nitrous acid ester inhaler-rush poppers use in men who have sex with (MSM). Methods: From April to June 2014, October December 2015, three round cross-sectional surveys were conducted MSM recruited Nanjing by means serum test and questionnaire survey. Results: Of 1 721 surveyed round, 19.3% (332/1 721) had ever used rush poppers, proportions showed an increasing trend (liner liner χ(2)= 14.879, P=0.000), which was 12.6% (86/681),...
To understand the epidemiology, evolutionary and transmission characteristics of HIV-1 CRF07_BC in Nanjing, China. One hundred fifty-nine patients with were recruited. DNA sequencing, phylogenetic analysis, molecular cluster analysis conducted to determine epidemiology characteristics. Of these HIV-1-infected patients, 95.6% male, men who sex (76.7%) main route. Only 34.0% cases born most them (64.8%) reported having multiple partners last 6 months. The maximum likelihood analyses revealed...
Description of the transmission characteristics among older adults is helpful for tailored interventions. Epidemiological investigation combined with phylogenetic analysis were performed to reveal potential linkage people in Nanjing. During 2018-2022, 188 pol sequences successfully amplified. Multiple genotypes identified, including CRF07_BC (55.3%), CRF01_AE (30.3%), CRF08_BC (8.0%), B (3.2%), CRF55_01B (1.1%), CRF67_01B (0.5%),CRF68_01B (0.5%), and unique recombinant forms (URF) (1.1%)....
<sec> <title>BACKGROUND</title> The HIV-1 molecular network is an innovative tool, using gene sequences to understand transmission attributes and complementing social sexual studies. While previous research focused on static characteristics, recent studies’ emphasis dynamic features enhances our understanding of real-time changes, offering insights for targeted interventions efficient allocation public health resources. </sec> <title>OBJECTIVE</title> This study aims identify the changes...
ABSTRACT Describing the transmission characteristics among older adults is essential for designing tailored interventions. An epidemiological investigation combined with phylogenetic analysis was conducted to reveal potential linkages in Nanjing. Between 2018 and 2022, 188 pol sequences were successfully amplified. Multiple genotypes identified, including CRF07_BC (55.3%), CRF01_AE (30.3%), CRF08_BC (8.0%), B (3.2%), CRF55_01B (1.1%), CRF67_01B (0.5%), CRF68_01B unique recombinant forms...
Objective: To analyze the survival time of reported HIV/AIDS and influencing factors Yunnan Province from 1989 to 2021. Methods: The data were extracted Chinese comprehensive response information management system. retrospective cohort study was conducted. life table method applied calculate probability. Kaplan-Meier used draw curves in different situations. Furthermore, Cox proportion hazard regression model constructed identify related time. Results: Of 174 510 HIV/AIDS, all-cause...
Objective: To investigate the prevalence, awareness, treatment and control rate of hypertension among Dongxiang population county in Gansu province, analyze risk factors this population. Methods: A total 1 879 residents province aged 18 years over were selected one town eight villages by random cluster method from April to June 2014. All subjects interviewed physical examination including blood pressure measurement was performed. Multivariate logistic regression analysis used hypertension....
<title>Abstract</title> Objective The objective of this study was to conduct a comprehensive analysis the molecular transmission networks and transmitted drug resistance (TDR) patterns among individuals newly diagnosed with HIV-1 in Nanjing. Methods Plasma samples were collected from HIV patients Nanjing between 2019 2021. pol gene amplified, resulting sequences utilized for determining TDR, identifying viral genotypes, constructing networks. Logistic regression analyses employed investigate...
Objective: To understand the characteristics of newly detected HIV infection cases and related high risk behaviors in areas with HIIV prevalence Yunnan province. Methods: A questionnaire survey was conducted census method during January to March 2016 among infected persons Dehong, Honghe, Lincang Dali prefectures 2012-2015. Results: Among 451 seropositive cases, major transmission route heterosexual contact, accounting for 92.5% (417/451). The total awareness rate AIDS knowledge 73.0%...
Abstract Objective To describe the epidemiological characteristics of PLHIV, and to assess age spatial distribution HIV prevalence over last decade in Nanjing. Methods We downloaded information reported PLHIV from Chinese HIV/AIDS comprehensive prevention system, we performed descriptive, one-way ANOVA, autocorrelation analysis, scanning mapping distribution. Results 5269 that fulfilled inclusion exclusion criteria were included our study. The for each year rose 1.09/10000 2011 5.70/10000...