A5100328306- Bone Tumor Diagnosis and Treatments
- Sarcoma Diagnosis and Treatment
- Hepatitis B Virus Studies
- Oral and Maxillofacial Pathology
- Head and Neck Surgical Oncology
- Cervical Cancer and HPV Research
- Oral microbiology and periodontitis research
- Bipolar Disorder and Treatment
- Folate and B Vitamins Research
- Hepatitis C virus research
- Antifungal resistance and susceptibility
- Attention Deficit Hyperactivity Disorder
- Influenza Virus Research Studies
- Antimicrobial Peptides and Activities
- Inflammatory Biomarkers in Disease Prognosis
- Antimicrobial Resistance in Staphylococcus
- Obsessive-Compulsive Spectrum Disorders
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Tumors and Oncological Cases
- Respiratory viral infections research
- Heart rate and cardiovascular health
- NF-κB Signaling Pathways
- Immune Response and Inflammation
Capital Medical University
2016-2025
Nanjing Medical University
2025
Nanjing Jiangning Hospital
2025
Beijing Chao-Yang Hospital
2021-2025
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2024
Affiliated Hospital of Jining Medical University
2024
Guangdong University of Technology
2022
Beijing Institute of Neurosurgery
2016-2021
Peking University
2019-2020
Beijing Anding Hospital
2017-2018
Chordoma is a rare bone tumor with an unknown etiology and high recurrence rate. Here we conduct whole genome sequencing of 80 skull-base chordomas identify PBRM1, SWI/SNF (SWItch/Sucrose Non-Fermentable) complex subunit gene, as significantly mutated driver gene. Genomic alterations in PBRM1 (12.5%) homozygous deletions the CDKN2A/2B locus are most prevalent events. The combination chromosome 22q deletion, which involves another gene (SMARCB1), shows strong associations poor...
To analyze the transmission characteristics of newly reported HIV-infected students aged ≥18 years in Nanjing City from 2016 to 2022 and provide evidence for AIDS publicity intervention among young students. The pol region sequences non-student individuals were collected, BLAST tool was used search published global non-Nanjing HIV infection LANL database. basic molecular network regional constructed using HIV-TRACE a pairwise genetic distance threshold 1.0%. 332 infected aged≥18 City, 1 904...
Introduction Vancomycin-resistant Enterococcus faecium (VRE-fm) biofilms pose a significant clinical challenge due to the limited effectiveness of traditional antibiotics. This study investigates potential γ-linolenic acid (GLA) as novel antibiofilm agent. Methods Transcriptome analysis was performed on V27 isolate, comparing cells in mature treated with and without GLA. The findings were further validated using qRT-PCR six VRE-fm isolates two E. faecalis isolates. Results revealed...
Adiponectin is an adipocyte-secreted cytokine that enhances insulin sensitivity and attenuates inflammation. Although circulating adiponectin level often inversely associated with several malignancies, its role in the development of nasopharyngeal carcinoma (NPC) remains unclear. Here, we investigated clinical association between NPC, examined impact adiponectin, as well underlying mechanisms, on NPC growth both vitro vivo.
OBJECTIVEIn this study, the authors' aim was to research clinical features and prognostic factors in patients harboring clival chordomas explore relationship between platelet-derived growth factor receptor-β (PDGFR-β) expression tumor invasion prognosis of chordoma.METHODSA total 242 were retrospectively analyzed. Clinical information, including extent resection, Al-Mefty classification, postoperative complications, radiotherapy, reviewed. Kaplan-Meier analysis used estimate survival time....
Chordoma shows poor patient prognosis because of its high recurrence rate. Even though many clinical factors and biomarkers are reported to be associated with prognosis, no prediction model has been applied clinically. Thus, the authors aim derive validate a prognostic nomogram predict progression-free survival (PFS) chordoma.
Enterococcus faecium is a leading cause of hospital-acquired infections, which has become serious public health concern. The increasing incidence vancomycin-resistant E. (VRE-fm) raises an urgent need to find new antimicrobial agents as complement traditional antibiotics. study aimed evaluate the and antibiofilm activity essential fatty acids (EFAs) against VRE-fm, further explore molecular mechanism EFAs.The microdilution broth method was used for susceptibility testing with antibiotics...
<sec><strong>Objective</strong> To investigate the impact of CYP2C19 gene polymorphism on clopidogrel reactivity and its association with long-term clinical outcome in patients coronary heart disease (CHD) undergoing percutaneous intervention (PCI). </sec><sec><strong>Methods</strong> In total, 675 were enrolled. Based platelet inhibition rate, categorized into two groups: low responsiveness (CLR) normal (NCR). The CLR group was divided ticagrelor based antiplatelet drugs used follow-up...
The biofilm formation of Candida albicans is an important virulence factor as it can increase tolerance to conventional antifungal drugs and the host immune system. study aimed assess effect essential fatty acids (EFAs) against mature biofilms C. strains, which were isolated from vulvovaginal candidiasis candidemia. ability activities fluconazole determined. Additionally, effects six EFAs [α-linolenic acid (ALA), eicosapentaenoic (EPA), docosahexaenoic (DHA), linoleic (LOA), γ-linolenic...
BACKGROUND:The aim of this study was to evaluate the awareness human papillomavirus (HPV), knowledge HPV-associated diseases, as well willingness undergo HPV vaccination among male university students in China, especially factors influencing willingness. MATERIAL AND METHODS:We conducted a cross-sectional Beijing, Tianjin, and Hebei, China by using convenience sampling method. We assessed a) HPV, b) c) vaccination, d) sexual behaviors students. RESULTS:A total 1274 aged 16 26 years old were...
Few researches focused on human papillomavirus (HPV) in male patients. This study aimed to explore the detection rate and genotyping of HPV among patients Beijing provide a reference for formulating prevention strategies infection. The cross-sectional was conducted Chaoyang Hospital from November 2015 March 2023. It covered urology dermatology departments. Fifteen high-risk genotypes were detected by multiplex real-time polymerase chain reaction method. 95% confidence interval (CI)...
To examine whether immunohistochemistry of methylthioadenosine phosphorylase (MTAP) and p16 could be used to predict the CDKN2A status in various brain tumors.
Abstract Background Increasing studies have demonstrated that activated platelets play an essential role in tumour progression. However, the level and prognostic of platelet indices chordoma patients remain unclear. The aim current study was to characterize performance count (PLT), mean volume (MPV) distribution width (PDW) skull base patients. Methods 187 primary between January 2008 September 2014 were enrolled this retrospective study. optimal cut-off values determined by X-tile software,...
Electroconvulsive therapy (ECT) is an effective treatment for psychiatric disorders such as schizophrenia, major depression and bipolar disorder. However, few studies have addressed the use of ECT in adolescents with schizophrenia. The aims our study were to investigate frequency ECT, its relationship clinical demographic correlates among schizophrenia China. was a retrospective conducted Child Adolescent Psychiatry Department Beijing Anding Hospital, over period 10 years (2007–2016)...
Skull base chordomas in pediatric and adolescent patients are rare challenging for surgeons.Well-specified diagnosis treatment of great value the long-term control chordoma. This study summarizes well-followed chordoma (PAC) treated a single Asian center.PAC were enrolled. Data collected included clinical presentation, tumor volume, texture, surgical approach, pathology, complications, adjuvant radiotherapy (RT), outcomes.Sixty-two identified from total 516 skull (12%). Diplopia was most...