A5101964955- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Ferroptosis and cancer prognosis
- High-Voltage Power Transmission Systems
- Cancer Immunotherapy and Biomarkers
- Power Systems and Renewable Energy
- Circular RNAs in diseases
- CAR-T cell therapy research
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- Anesthesia and Pain Management
- Radiopharmaceutical Chemistry and Applications
- Apelin-related biomedical research
- Plant Pathogens and Fungal Diseases
- Cardiac Fibrosis and Remodeling
- Oral and Maxillofacial Pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Geriatric Care and Nursing Homes
- Head and Neck Surgical Oncology
- Maternal Mental Health During Pregnancy and Postpartum
- Maternal and Perinatal Health Interventions
Jiangxi Provincial Cancer Hospital
2025
Xijing Hospital
2025
Air Force Medical University
2025
Zhejiang University
2010-2025
Qilu Hospital of Shandong University
2025
Langfang Normal University
2024
Jilin Province Tumor Hospital
2024
Shanxi Medical University
2017-2024
Wenzhou Medical University
2013-2024
Ruian People's Hospital
2024
Bacterial infection often induces chronic repair of wound healing owing to aggravated inflammation. Hydrogel dressing exhibiting intrinsic antibacterial activity may substantially reduce the use antibiotics for infected management. Hence, a versatile hydrogel (rGB/QCS/PDA-PAM) skin adaptiveness on dynamic wounds and mild photothermal is developed safe efficient treatment. Phenylboronic acid-functionalized graphene (rGB) oxadiazole-decorated quaternary carboxymethyl chitosan (QCS) are...
Abstract Doxorubicin-induced cardiotoxicity (DIC), which is a cardiovascular complication, has become the foremost determinant of decreased quality life and mortality among survivors malignant tumors, in addition to recurrence metastasis. The limited ability accurately predict occurrence severity doxorubicin-induced injury greatly hindered prevention DIC, but reducing dose mitigate side effects may compromise effective treatment primary malignancies. This posed longstanding clinical...
Autophagy is a lysosomal degradation pathway that can provide energy through its recycling mechanism to act as cytoprotective adaptive response mediating treatment resistance in cancer cells. We investigated the autophagy-inducing effects of ZD6474, small-molecule inhibitor blocks activities vascular endothelial growth factor receptor (VEGFR), epidermal (EGFR), and RET tyrosine kinases. ZD6474 on autophagy glioblastomas The action was determined by western blot. then examined impacts...
Abstract Background The paucity of reliable biomarkers for predicting immunotherapy efficacy in patients with advanced hepatocellular carcinoma (HCC) has emerged as a burgeoning concern the expanding use immunotherapy. This study endeavors to delve into potential peripheral capable prognosticating HCC who are poised receive anti-PD-1 monotherapy within phase III clinical trial, KEYNOTE394. Additionally, we sought elucidate underlying molecular mechanisms resistance immune checkpoint blockade...
Melanoma is the deadliest form of skin cancer and one most aggressive cancers. ZFAS1 a newly identified lncRNA, playing an oncogenic role in several types cancer. The present study aimed to investigate function mechanism ZFAS1-induced regulation melanoma. expression was increased melanoma tissues cells compared with normal controls. metastatic higher than that nonmetastatic subjects. Higher predicted lower survival rates. Knockdown decreased proliferation, apoptosis, migration invasion,...
To investigate the role of translocase outer mitochondrial membrane 40 (TOM40) in oral squamous cell carcinoma (OSCC) with aim identifying new biomarkers or potential therapeutic targets. TOM40 expression level OSCC was evaluated using datasets downloaded from The Cancer Genome Atlas (TCGA), as well clinical data. correlation between and clinicopathological parameters survival were analyzed TCGA. signaling pathways associated identified through gene set enrichment analysis. A network genes...
Background: Traumatic brain injury (TBI) is a major cause of morbidity and mortality, often requiring emergency department (ED) management.Integrated Nursing Interventions play critical role in the care TBI patients, but limited research has evaluated their efficacy this setting.This study aims to assess impact Integrated on patient outcomes complications ED.Methods: This retrospective included 246 patients with mild traumatic (mTBI) treated from January 2022 December 2022.Of these, 138...
Immunotherapy, exemplified by immune checkpoint blockade (ICB), has been extensively employed in antitumor treatments. Nevertheless, its efficacy addressing low-immunogenic tumors not yielded satisfactory results, primarily due to the depletion and inadequate infiltration of effector T cells within tumor microenvironment (TME). Here, we construct an injectable water-in-oil emulsion hydrogel load clinically used Celastrol (Gel@Cel), which addresses limitations Cel's hydrophobicity. Cel can...
Abstract Background Previous studies had demonstrated that aldo‐keto reductase family 1 member C3 (AKR1C3), a crucial enzyme in the steroidogenic pathway, played an important role abiraterone (ABI)‐resistance metastatic castration‐resistant prostate cancer (mCRPC) by increasing intratumoral androgen synthesis. However, its value predicting treatment response patients with mCRPC is unknown. Method and Materials Data of 163 between 2016 2018 were retrospectively analyzed. All received...
Intraductal carcinoma of the prostate is an adverse prognosticator cancer. However, roles proportion and architectural patterns intraductal in patient outcomes remain unclear.We retrospectively analyzed data on 644 patients with de novo metastatic cancer between 2010 2017. was identified from 12-core biopsy. We calculated according to 2016 WHO classification. Propensity score matching performed balance baseline characteristics without carcinoma. Kaplan-Meier curves Cox regression were used...
This study aimed to compare the postoperative analgesic effects of tramadol and hydromorphone for secondary cesarean delivery (CD) as well their anti-anxiety anti-depression properties.A total 106 patients receiving CD under spinal anesthesia were randomly allocated group (n=53) (n=53). Each received patient-controlled intravenous analgesia using flurbiprofen 4 mg/kg combined with (4 mg/kg) or (0.04 immediately after surgery. Postoperative pain numerical rating scale (NRS) incision visceral...
Background: Metastasis is the primary cause of death in colorectal cancer (CRC); underlying mechanisms remain partly unknown. In this study, we aim to investigate value HOXA11-AS survival evaluation and potential role HOXA11-AS/miR-149-3p axis CRC metastasis. Methods: The expressions HOXA11-AS, both obtained samples adjacent noncancerous tissues, were analyzed evaluation. Competing endogenous RNAs (CeRNAs) Analysis employed reveal relationship between miR-149-3p. It was further confirmed by...
Malignant melanoma is an aggressive form of cancer which highly resistant to chemotherapy. We have previously found that gambogic acid (GA), a kind polyprenylated xanthone, exhibits antitumour role in melanoma. The study was designed investigate novel mechanisms the effect GA cells and implanted nude mice. Gambogic significantly decreased cell viability, increased apoptosis reduced migration invasion A375 cells. In addition, cisplatin-induced cytotoxicity both A375/CDDP by GA. expression...
Summary Soil contamination with arsenic (As) can cause phytotoxicity and reduce crop yield. The mechanisms of As toxicity tolerance are not fully understood. In this study, we used a forward genetics approach to isolate rice mutant, ahs1 , that exhibits hypersensitivity both arsenate arsenite. Through genomic resequencing complementation tests, identified OsLPD1 as the causal gene, which encodes putative lipoamide dehydrogenase. was expressed in outer cell layer roots, root meristem cells,...