A5040415545- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Single-cell and spatial transcriptomics
- Histone Deacetylase Inhibitors Research
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- Phytase and its Applications
- Ubiquitin and proteasome pathways
- Phagocytosis and Immune Regulation
- RNA Interference and Gene Delivery
- Amino Acid Enzymes and Metabolism
- Supramolecular Self-Assembly in Materials
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroendocrine Tumor Research Advances
- Cancer Research and Treatments
Zhejiang University
2021-2025
First Affiliated Hospital Zhejiang University
2021-2024
Ministry of Education of the People's Republic of China
2022
Nanchang University
2019
Abstract Intrahepatic cholangiocarcinoma (ICC) is a relatively rare but highly aggressive tumor type that responds poorly to chemotherapy and immunotherapy. Comprehensive molecular characterization of ICC essential for the development novel therapeutics. Here, we constructed two independent cohorts from clinic centers. A comprehensive multiomics analysis via proteomic, whole-exome sequencing (WES), single-cell RNA (scRNA-seq) was performed. Novel subtypes were derived in training cohort (n =...
Colorectal cancer (CRC) is a common malignancy involving multiple cellular components. The CRC tumor microenvironment (TME) has been characterized well at single-cell resolution. However, spatial interaction map of the TME still elusive. Here, we integrate multiomics analyses and establish to improve prognosis, prediction, therapeutic development for CRC. We construct immune module (CCIM) that comprises FOLR2+ macrophages, exhausted CD8+ T cells, tolerant CD4+ regulatory cells. Multiplex...
The combination of ferroptosis inducers and immune checkpoint blockade can enhance antitumor effects. However, the efficacy in tumors with low immunogenicity requires further investigation. In this work, a water-in-oil Pickering emulsion gel is developed to deliver (1S, 3R)-RSL-3 (RSL-3), inducer dissolved iodized oil, programmed death-1 (PD-1) antibody, most commonly used inhibitor water, optimal characteristics (RSL-3 + PD-1@gel). Tumor lipase degrades continuous oil phase, which results...
Despite the epidemiological association between intrahepatic cholangiocarcinoma (ICC) and hepatitis B virus (HBV) infection, little is known about relevant oncogenic effects. A cohort of 32 HBV-infected ICC 89 non-HBV-ICC patients were characterized using whole-exome sequencing, proteomic analysis, single-cell RNA sequencing. Proteomic analysis revealed decreased cell-cell junction levels in HBV-ICC patients. The level had an inverse relationship with epithelial-mesenchymal transition (EMT)...
Intrahepatic cholangiocarcinoma is a rare disease associated with poor prognosis, primarily due to early recurrence and metastasis. An important feature of this condition microvascular invasion (MVI). However, current predictive models based on imaging have limited efficacy in regard. This study employed random forest model construct for MVI identification uncover its biological basis. Single-cell transcriptome sequencing, whole exome proteome sequencing were performed. The area under the...
Robust strategies to identify patients at high risk for tumor metastasis, such as those frequently observed in intrahepatic cholangiocarcinoma (ICC), remain limited. While gene/protein expression profiling holds great potential an approach cancer diagnosis and prognosis, previously developed protocols using multiple diagnostic signatures expression-based metastasis prediction have not been widely applied successfully because batch effects different data types greatly decreased the predictive...
Abstract Background Patients with intrahepatic cholangiocarcinoma (ICC) are prone to recurrence and poor survival. Targeted therapy related isocitrate dehydrogenase (IDH) is an extremely important treatment. IDH1 IDH2 mutations generally thought have similar effects on the tumor landscape. However, it doubtful whether these 2 exactly same cells microenvironment. Methods All collected samples were subjected simultaneous whole-exon sequencing proteome sequencing. Results accounted for 12.2%,...
e16235 Background: Oxaliplatin (OXA) can be used as a palliative treatment for advanced hepatocellular carcinoma (HCC). While most patients still have rapid disease progression after OXA due to the drug resistance. The lactate dehydrogenase A (LDHA) inhibitors reduce inflammation-induced effects, metastasis, and proliferation potential of cancer cells. combination LDHA inhibitor may an effective HCC. Methods: We adopt water-in-oil attractive Pickering emulsion gel (APEG) deliver inhibitor,...
e16347 Background: Chemotherapy is indispensable for the systematic treatment of aggressive malignancies, such as pancreatic ductal adenocarcinoma (PDAC), while delivery vehicles are essential improving efficiency and enhancing anti-tumor therapy. Methods: We design synthesize tumor-targeting PLA/shellac-FA dimer nanoparticles (NPs). Paclitaxel (PTX) curcumin (CUR) co-loaded in NPs. In vitro, we apply CCK8 assay to investigate cell uptake different particle shape. vivo, shape NPs injected...
<div>Abstract<p>Intrahepatic cholangiocarcinoma (ICC) is a relatively rare but highly aggressive tumor type that responds poorly to chemotherapy and immunotherapy. Comprehensive molecular characterization of ICC essential for the development novel therapeutics. Here, we constructed two independent cohorts from clinic centers. A comprehensive multiomics analysis via proteomic, whole-exome sequencing (WES), single-cell RNA (scRNA-seq) was performed. Novel subtypes were derived in...
<div>Abstract<p>Intrahepatic cholangiocarcinoma (ICC) is a relatively rare but highly aggressive tumor type that responds poorly to chemotherapy and immunotherapy. Comprehensive molecular characterization of ICC essential for the development novel therapeutics. Here, we constructed two independent cohorts from clinic centers. A comprehensive multiomics analysis via proteomic, whole-exome sequencing (WES), single-cell RNA (scRNA-seq) was performed. Novel subtypes were derived in...
Supplementary Figure from Molecular Subgroups of Intrahepatic Cholangiocarcinoma Discovered by Single-Cell RNA Sequencing–Assisted Multiomics Analysis
Supplementary Figure from Molecular Subgroups of Intrahepatic Cholangiocarcinoma Discovered by Single-Cell RNA Sequencing–Assisted Multiomics Analysis
Supplementary Figure from Molecular Subgroups of Intrahepatic Cholangiocarcinoma Discovered by Single-Cell RNA Sequencing–Assisted Multiomics Analysis
Supplementary Figure from Molecular Subgroups of Intrahepatic Cholangiocarcinoma Discovered by Single-Cell RNA Sequencing–Assisted Multiomics Analysis