Study objectiveKidney neoplasms have a high incidence, and radical nephrectomy or partial are the main treatment options. Our study aims to investigate use of ultrasound-guided erector spinae plane block for perioperative analgesia in patients undergoing laparoscopic surgery.DesignProspective, randomized, double-blind.SettingUniversity hospital.PatientsOur included 50 (ASA I-III) who underwent at hospital Second Affiliated Hospital Army Medical University.InterventionsThe were divided into...

The study aimed to investigate the effects of intraoperative dexmedetomidine on postoperative sleep disturbance for different surgical patients and compare such between dose dexmedetomidine.A total 7418 undergoing nine types non-cardiac major surgeries were retrospectively studied. Patients separated into DEX (dexmedetomidine) or Non-DEX (Non-dexmedetomidine) groups based use during surgery. who reported they could not fall asleep night woke up repeatedly most at day surgery whose NRS >6...

Background Postoperative depression is one of the most common mental disorders in patients undergoing cancer surgery and it often delays postoperative recovery. We investigated whether dezocine, an analgesic with inhibitory effect on serotonin norepinephrine reuptake, could relieve depressive symptoms colorectal surgery. Methods This randomized, controlled, single-center, double-blind trial was performed Second Affiliated Hospital Army Medical University. A total 120 were randomly assigned...

Abstract Background Estimating the depth of anaesthesia (DoA) is critical in modern anaesthetic practice. Multiple DoA monitors based on electroencephalograms (EEGs) have been widely used for monitoring; however, these may be inaccurate under certain conditions. In this work, we hypothesize that heart rate variability (HRV)-derived features a deep neural network can distinguish different states, providing secondary tool assessment. Methods A novel method distinguishing states was developed...

This study aimed to compare the postoperative analgesic effects of tramadol and hydromorphone for secondary cesarean delivery (CD) as well their anti-anxiety anti-depression properties.A total 106 patients receiving CD under spinal anesthesia were randomly allocated group (n=53) (n=53). Each received patient-controlled intravenous analgesia using flurbiprofen 4 mg/kg combined with (4 mg/kg) or (0.04 immediately after surgery. Postoperative pain numerical rating scale (NRS) incision visceral...

Antenatal depression is a prevalent mental disorder in women who have undergone caesarean section, and it often presages adverse postoperative outcomes. Because of the lack laboratory-based diagnostic strategy, antenatal mainly determined by psychologist's subjective judgment based on structured clinical interview for established criteria. However, accuracy rate non-psychiatrists relatively low. Thus, this study aimed to use lipidomics identify potential biomarkers related section. The was...

Background: Postpartum depression (PPD) is a severe psychiatric disorder. Its risk associated with the cesarean section (CS). Currently, there are few early intervention strategies for these women PPD who underwent CS. Methods: This was parallel-group randomized controlled trial of singleton pregnant elective CS in tertiary referral hospital China from October, 2017 to September, 2019. After operation, patients received randomly tramadol patient-controlled intravenous analgesia (PCIA; 4...

Abstract Background Laparoscopic nephrectomy is a commonly utilized surgical approach for the management of renal cancer. Despite its widespread acceptance, postoperative pain remains significant challenge many patients undergoing this procedure. Traditional techniques, including opioid and nonsteroidal anti-inflammatory drug administration, may not provide adequate relief result in adverse effects. In recent years, erector spinae plane block (ESPB) has emerged as promising regional...

In several recent studies, proteomics analyses suggest that increase of ubiquinol-cytochrome c reductase core protein 1 (UQCRC1) is cardio-protective. However, direct evidence for this effect has not yet been obtained. Thus, the current study aimed to determine and mechanism underlying effect. The results showed overexpression UQCRC1 protected H9c2 cardiac cells against in vitro simulated ischemia-reperfusion by maintaining mitochondrial membrane potential suppressing expression caspase-3....

To explore the effect of glucose-insulin-potassium (GIK) therapy on uterine cramping pain (UCP) following cesarean delivery (CD).Single-center, randomized controlled study.Second Affiliated Hospital Army Medical University, Chongqing, China.A total 140 women, aged 20-40 years, who underwent CD with a transverse incision were randomly assigned to GIK (P) or control (C) groups in 1:1 ratio.GIK was intravenously administered patients Group P. Patients C received normal saline (NS). After...

Background This study aimed to compare the consistency of anesthesia consciousness index (Ai) with that bispectral (BIS) in monitoring depth (DOA) during sevoflurane anesthesia, reveal optimal cutoff values different states consciousness, and explore stability DOA intraoperative injurious stimulation. Methods We enrolled 145 patients (97 men 48 women) from 10 medical centers. General was induced using intravenous anesthetics maintained sevoflurane. Ai BIS were recorded. Results The mean...

Introduction Postpartum depression is one of the most commonly experienced psychological disorders for women patients undergoing caesarean section, which accounts about one-third puerpera worldwide. Tramadol, a used analgesic with an inhibitory effect on reuptake norepinephrine and serotonin, effective well-tolerated agent analgesia after section. Based role changes in postpartum levels serotonin depression, we speculated that postoperative intravenous using tramadol may decrease incidence...

Abstract Adolescent idiopathic scoliosis (AIS), a sideways curvature of the spine, is most common pediatric musculoskeletal disorder, affecting ∼3% population worldwide. However, its genetic bases and tissues origin remain largely unknown. Several genome-wide association studies (GWAS) have implicated nucleotide variants in noncoding sequences that control genes with important roles cartilage, muscle, bone, connective tissue intervertebral discs (IVDs) as drivers AIS susceptibility. Here, we...

This study aimed to use long-term diazoxide treatment establish a loss-of-cardioprotection model and then perform proteomics analysis explore which proteins of mitochondrial inner membrane (MIM) are potentially involved in delayed cardioprotection. Rats received 1 8 weeks treatments (20 mg•kg-1•d-1) different groups. Detection serum cTnI levels cell apoptosis assays heart tissue were performed. Then, rats MIM after 0, 4 6 was isolated An invitro H9C2 cells performed the effects targeted...

Abstract Background The Society for Obstetric Anesthesia and Perinatology recommends a multimodal analgesia regimen cesarean delivery analgesia. This study aimed to compare the analgesic effects of tramadol alone combined with butorphanol or flurbiprofen axetil after section. Methods We performed retrospective analysis based on electronic medical records teaching hospital in China from January 2018 2020. collected data demographic characteristics, anesthesia, strategy, pain intensity...

Ubiquinol-cytochrome c reductase core protein 1 (UQCRC1) is an indispensable component of mitochondrial complex III. It plays a key role in cardioprotection and maintaining mitochondrion function. However, the exact UQCRC1 cardiac function has not been reported by vivo models. Also, biological functions are far from fully understood. +/− mice had decreased both mRNA expression left ventricular myocardia, these reduced tolerance to acute exhaustive exercise including time distance with higher...

Abstract This study aimed to explore the effect of glucose-insulin-potassium (GIK) on postpartum uterine cramping pain(UCP) in mice and possible underlying mechanisms. Thirty full-term pregnancy C57BL/6 mice, within 6 h after spontaneous labor, were randomly assigned into following three groups: control group (group C), oxytocin O), GIK plus G). Group G O administered normal saline, respectively, 10 min later, was injected intraperitoneally; C received saline twice. The pain scores assessed...

Delayed neurocognitive recovery (DNR) is a cognitive change that affects patients after anesthesia and surgery, with high incidence, severely impairing their quality of life. We identified relevant metabolic pathways to determine predictive lipid markers understand the pathogenesis DNR.A non-targeted lipidomic strategy using Waters Acquity I Class UPLC-Xevo G2-S QTOF UPLC-MS was employed identify different lipids in 24 h postoperative plasma whose function assessed 7-14 days surgery....

Abstract Background In this study, we aimed to analyse survey data explore two different hypotheses; and for purpose, distributed an online Chinese anaesthesiologists. The hypothetical questions in include: (1) anaesthesiologists mainly use the depth of anaesthesia (DoA) monitors prevent intraoperative awareness (2) accuracy these is most crucial performance factor during clinical daily practice Methods We collected statistically analysed response a total 12,750 anesthesiologists who were...

Rationale, aims and objectives: To determine current practices, attitudes demands of Chinese anesthesiologists regarding depth anesthesia (DoA) monitoring. Method: An anonymous online survey was randomly distributed to 8,556 anesthesiologists. Results: The overall response rate 47% (4,037 respondents). Only 9.1% (95% confidence interval, 8.2%-10.0%) the respondents routinely use DoA monitors. main factors influencing utility monitors were poor anti-interference ability (56.0%, 54.5%-57.6%),...

Background: Our previous study found that a long-term diet incorporating spicy foods can reduce the human basal pain threshold. Capsaicin is pungent ingredient in chili peppers. Transient receptor potential vanilloid type1 capsaicin expressed oral cavity and primary sensory neuron of “pain” pathway. Few studies have examined association between chronic postsurgical (CPSP). Women who underwent elective cesarean section (eCS) consistent characteristics CPSP. This aimed to investigate...

Abstract Background: To our knowledge, the Society for Obstetric Anesthesia and Perinatology recommends a multimodal analgesic regimen caesarean delivery analgesia. Therefore, this study aimed to compare effects of tramadol alone in combination with butorphanol or flurbiprofen axetil after section. Methods : We retrospectively analysed 2323 women puerperas who had undergone section based on electronic medical records teaching hospital China from January 2018 2020. collected data demographic...