A5078573167- Hedgehog Signaling Pathway Studies
- Nonmelanoma Skin Cancer Studies
- Cancer and Skin Lesions
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Ischemia and Reperfusion
- Hemodynamic Monitoring and Therapy
- Anesthesia and Neurotoxicity Research
- Mitochondrial Function and Pathology
- Anesthesia and Sedative Agents
- Neuroscience and Neuropharmacology Research
- Enzyme Production and Characterization
- Plant Pathogens and Resistance
- Lipid metabolism and disorders
- ATP Synthase and ATPases Research
- Plant tissue culture and regeneration
- Biofuel production and bioconversion
- Fern and Epiphyte Biology
- Adipose Tissue and Metabolism
- Hematological disorders and diagnostics
- Berberine and alkaloids research
- Animal Virus Infections Studies
- Drug Solubulity and Delivery Systems
- Synthesis and Biological Activity
- Microbial bioremediation and biosurfactants
- Viral gastroenteritis research and epidemiology
Chongqing Medical University
2017-2024
Zunyi Medical University
2024
Xinqiao Hospital
2013-2023
Army Medical University
2013-2023
Shandong Agricultural University
2022
Second Affiliated Hospital of Chongqing Medical University
2021
Dalian Medical University
2021
Affiliated Hospital of North Sichuan Medical College
2020
Johnson & Johnson (Israel)
2017
Novartis (Switzerland)
2017
Abstract Background Patients with locally advanced basal cell carcinoma (laBCC) or metastatic BCC (mBCC), two difficult‐to‐treat populations, have had limited treatment options. Sonidegib, a hedgehog pathway inhibitor (HPI), was approved in laBCC based on results from the BOLT trial. Objective To evaluate long‐term efficacy and safety of sonidegib mBCC 18‐ 30‐month analyses. Methods (NCT01327053, ClinicalTrials.gov), double‐blind phase 2 study, enrolled patients July 2011 until January 2013....
The hedgehog pathway inhibitor sonidegib demonstrated meaningful tumor shrinkage in more than 90% of patients with locally advanced basal cell carcinoma (BCC) or metastatic BCC the Outcomes LDE225 Treatment study.This report provides long-term follow-up data collected up to 12 months after last patient was randomized.In this multicenter, randomized, double-blind phase II study, were randomized 1:2 200 800 mg. primary end point objective response rate assessed by central review.Objective...
Abstract Background Accumulating evidence has demonstrated that long non‐coding RNAs (lncRNAs) MIAT is significantly upregulated in many cancer types including gastric (GC). However, the potential clinical significance of serum exosomal GC unknown. Methods In this study, a total 109 patients, 48 adenoma and 50 healthy individuals were recruited. Serum levels detected all participants using quantitative real‐time reverse transcription‐polymerase chain reaction (qRT‐PCR). Results The exosomes...
Sevoflurane has been the most widely used inhaled anesthetics with a favorable recovery profile; however, precise mechanisms underlying its anesthetic action are still not completely understood. Here authors show that sevoflurane activates cluster of urocortin 1 (UCN1
Despite extensive studies on the antitumor properties of berberine, a small molecule derived from Coptidis rhizoma (Huanglian in Chinese) and many other plants, underlying mechanism remains poorly understood. Here, we found that berberine-induced cell apoptosis human gastric cancer cells with increase expression level cleaved poly ADP-ribose polymerase caspase-3, impairment mitochondrial membrane potential (Δψm) berberine-treated cells. In our further studies, results demonstrated...
9009a^ Background: Pts with advanced BCC have limited treatment options. Sonidegib blocks the hedgehog pathway (overexpressed in ≥ 95% of BCCs) by selective inhibition smoothened. Methods: In this ph 2 study (BOLT; NCT01327053), pts LaBCC, not amenable to curative surgery or radiation, mBCC were randomized 1:2 receive sonidegib 200 800 mg daily. The primary endpoint, objective response rate (ORR—histopathologically confirmed complete [CR] + partial [PR]—achieved if point estimate 30% and CI...
Abstract Alzheimer's disease (AD) is a chronic and progressive neurodegenerative condition that influenced by multiple factors along with neuroinflammation oxidative stress. Our previous study proved Lithocarpus polystachyus Rehd. aqueous extract (sweet tea extract, STAE) effectively inhibits hydrogen peroxide‐induced neuronal cell injury. However, it not clear whether STAE can protect against AD, its underlying mechanisms are still uncertain. Therefore, the present was designed to evaluate...
In several recent studies, proteomics analyses suggest that increase of ubiquinol-cytochrome c reductase core protein 1 (UQCRC1) is cardio-protective. However, direct evidence for this effect has not yet been obtained. Thus, the current study aimed to determine and mechanism underlying effect. The results showed overexpression UQCRC1 protected H9c2 cardiac cells against in vitro simulated ischemia-reperfusion by maintaining mitochondrial membrane potential suppressing expression caspase-3....
Ubiquinol-cytochrome c reductase core protein 1 (UQCRC1) plays a key role in influencing mitochondrial function. Increasing evidence supports that UQCRC1 overexpression takes part cardioprotection. However, it remains unclear about the signaling pathway mediating protective of overexpression. Thus, current study aimed to investigate pathway. Inhibition PI3K completely abolished effects on cell viability and membrane potential after OGD or hydrogen peroxide injury H9c2 cardiac cells, while...
This study aimed to use long-term diazoxide treatment establish a loss-of-cardioprotection model and then perform proteomics analysis explore which proteins of mitochondrial inner membrane (MIM) are potentially involved in delayed cardioprotection. Rats received 1 8 weeks treatments (20 mg•kg-1•d-1) different groups. Detection serum cTnI levels cell apoptosis assays heart tissue were performed. Then, rats MIM after 0, 4 6 was isolated An invitro H9C2 cells performed the effects targeted...
Ubiquinol-cytochrome c reductase core protein 1 (UQCRC1) is an indispensable component of mitochondrial complex III. It plays a key role in cardioprotection and maintaining mitochondrion function. However, the exact UQCRC1 cardiac function has not been reported by vivo models. Also, biological functions are far from fully understood. +/− mice had decreased both mRNA expression left ventricular myocardia, these reduced tolerance to acute exhaustive exercise including time distance with higher...
<title>Abstract</title> Background To propose the novel scene reappearance-based learning method (SRBL) for education in medical humanities and to investigate whether this can be used curb negative humanistic behavior of anesthesia residents effectively context assessment block levels during spinal-epidural anesthesia. Methods Based on video recordings, we retrospectively found that employed nipping patients' skin with their fingers assess We further investigated incidence such among...
Background Recurrent illnesses and poor adherence to medical procedures render infants young children vulnerable procedural sedation, while repeated or prolonged exposure anesthetic medications sedative drugs may potentially exert adverse effects on the developing brain. Objective To investigate distribution of cumulative frequency use general in pediatric sedation for aged 0 3 years. Methods The records all treated Sedation Clinic Children's Medical Center our university November 2021 were...
9538 Background: Sonidegib 200 mg was approved for use in pts with advanced BCC (aBCC; laBCC + mBCC) or not amenable to surgery/radiotherapy based on results from BOLT (NCT01327053). Updated data the 30-month analysis (July 10, 2015 cutoff; 38.2-mo median follow-up) are reported. Methods: Pts mBCC received sonidegib 800 daily. Objective response rate (ORR; complete [CR] partial [PR]), duration of (DOR), and progression-free survival (PFS) were assessed (all pts; aggressive [eg, micronodular,...
e20055 Background: In the pivotal BOLT phase 2 study (NCT01327053), durable responses were observed in pts with advanced BCC treated sonidegib, a hedgehog pathway inhibitor (HPI). Treatment assessed using novel composite evaluation, which was more stringent than that used prior studies of HPIs BCC. this analysis, treatment evaluated sets criteria: BCC-mRECIST (A; BOLT) and BCC-mRECIST-like (B; similar to criteria other HPI less requirements for complete response [CR]). Methods: Assessments...
Abstract Background In this study, we aimed to analyse survey data explore two different hypotheses; and for purpose, distributed an online Chinese anaesthesiologists. The hypothetical questions in include: (1) anaesthesiologists mainly use the depth of anaesthesia (DoA) monitors prevent intraoperative awareness (2) accuracy these is most crucial performance factor during clinical daily practice Methods We collected statistically analysed response a total 12,750 anesthesiologists who were...
ABSTRACT: The purpose of the study was to prepare orally disintegrating tablets (ODTs) mosapride citrate for dogs with fast disintegration and low cost. ODTs were developed by varying components ratio excipients. A direct compression method used. properties ODTs, including hardness, friability, active ingredient content, in vitro time, investigated, an economic analysis formulations performed. For all formulations, friability less than 1%, hardness varied from 37.69±4.08 48.73±5.62 N, which...