A5100627810- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Circadian rhythm and melatonin
- Neuroscience and Music Perception
- Sleep and related disorders
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Hearing Loss and Rehabilitation
- Diverse Music Education Insights
- Neuroscience of respiration and sleep
- Pharmacological Effects of Natural Compounds
- EEG and Brain-Computer Interfaces
- Hearing, Cochlea, Tinnitus, Genetics
- Visual perception and processing mechanisms
- Music and Audio Processing
- Cytokine Signaling Pathways and Interactions
- Multisensory perception and integration
- Olfactory and Sensory Function Studies
- Electromagnetic Fields and Biological Effects
- Sleep and Work-Related Fatigue
- Anesthesia and Neurotoxicity Research
- Neuroendocrine regulation and behavior
- Decision-Making and Behavioral Economics
- Blind Source Separation Techniques
Army Medical University
2014-2025
Shanghai University of Traditional Chinese Medicine
2022-2024
Harbin Medical University
2024
Second Affiliated Hospital of Zhejiang University
2020
Beijing Fengtai Hospital
2017
Daping Hospital
2015
Beijing Normal University
2012-2015
McMaster University
2007-2013
A close view of the paraventricular thalamus The is a relay station connecting brainstem and hypothalamic signals that represent internal states with limbic forebrain performs associative functions in emotional contexts. Zhu et al. found thalamic neurons multiple salient features sensory stimuli, including reward, aversiveness, novelty, surprise. nucleus thus provides context-dependent salience encoding. gates information contributes to sleep-wake cycle through its interactions cerebral...
Abstract We investigated the emergence of discriminative responses to pitch by recording 2-, 3-, and 4-month-old infants' electro-encephalogram infrequent changes in piano tones. In all age groups, deviant tones were significantly different from standard However, two types mismatch observed simultaneously difference waves. An increase left-lateralized positive slow wave was prominent 2-month-olds, present 3-month-olds, but insignificant 4-month-olds. A faster adultlike negativity (MMN),...
In congenitally blind individuals, many regions of the brain that are typically heavily involved in visual processing recruited for a variety nonvisual sensory and cognitive tasks ( Rauschecker 1995; Pascual-Leone et al. 2005). This phenomenon—cross-modal plasticity—has been widely documented, but principles determine where how cross-modal changes occur remain poorly understood Bavelier Neville 2002). Here, we evaluate hypothesis plasticity respects type computations performed by region,...
The ability of the brain to predict future events based on pattern recent sensory experience is critical for guiding animal's behavior. Neocortical circuits ongoing processing stimuli are extensively studied, but their contributions anticipation upcoming remain less understood. We, therefore, used in vivo cellular imaging and fiber photometry record mouse primary auditory cortex elucidate its role anticipated stimulation. We found neuronal ensembles layers 2/3, 4, 5 which were activated...
Classical animal visual deprivation studies and human neuroimaging have shown that experience plays a critical role in shaping the functionality connectivity of cortex. Interestingly, recent additionally reported circumscribed regions cortex which functional selectivity was remarkably similar individuals with without experience. Here, by directly comparing resting-state task-based fMRI data congenitally blind sighted subjects, we obtained large-scale continuous maps degree to connectional...
Sevoflurane has been the most widely used inhaled anesthetics with a favorable recovery profile; however, precise mechanisms underlying its anesthetic action are still not completely understood. Here authors show that sevoflurane activates cluster of urocortin 1 (UCN1
Abstract Enhancement of wakefulness is a prerequisite for adaptive behaviors to cope with acute stress, but hyperarousal associated impaired behavioral performance. Although the neural circuitries promoting in stress conditions have been extensively identified, less known about circuit mechanisms constraining prevent hyperarousal. Here, we found that chemogenetic or optogenetic activation GAD2-positive GABAergic neurons midbrain dorsal raphe nucleus (DRN GAD2 ) decreased wakefulness, while...
Pitch perception is critical for the of speech and music, object identification, auditory scene analysis, whereby representations are derived each sounding in environment from complex sound wave that reaches ears. The perceived pitch a corresponds to its fundamental frequency. However, removal energy at does not alter because adults use harmonics derive (Bendor Wang, 2005; Trainor, 2008). Although frequency represented subcortically, integration into representation occur until cortex 2005)....
Heightened wakefulness in response to stressors is essential for survival but can also lead sleep disorders like insomnia. The paraventricular thalamus (PVT) both a critical thalamic area and stress-sensitive brain region. However, whether the PVT its neural circuitries are involved controlling stress conditions remains unknown. Here, we find that neurons projecting central amygdala (CeA) activated by different stressors. These wakefulness-active increase their activities upon transitions....
In order to process speech and music, the auditory cortex must learn patterns of sounds. Our previous studies showed that with a stream consisting repeating (standard) sound, younger infants show an increase in amplitude positive slow wave response occasional changes (deviants) pitch or duration, whereas older faster negative resembles mismatch negativity (MMN) adults (Trainor et al., 2001, 2003; He 2007). MMN reflects automatic change-detection does not require attention, conscious...
We examined adults’ and 6‐month‐old infants’ event‐related potentials in response to occasional changes (deviants) a 4‐note melody presented at different pitch levels from trial trial. In both groups, responses standard deviant stimuli differed significantly; however, adults produced typical mismatch negativity (MMN), whereas infants exhibited slow positive wave. conclude that infants, like adults, encode melodic information terms of relative distances, but the underlying cortical activity...
The medial entorhinal cortex (MEC) plays a crucial role in spatial learning and memory. Whereas the MEC receives dense histaminergic innervation from tuberomamillary nucleus of hypothalamus, functions histamine this brain region remain unclear. Here, we show that acts via H1Rs to directly depolarize principal neurons superficial, but not deep, layers when recording at somata. Moreover, decreases spontaneous GABA, glutamate, release onto superficial by acting presynaptic H3Rs without effect...