A5000132519- Sleep and Wakefulness Research
- Sleep and related disorders
- Circadian rhythm and melatonin
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Attention Deficit Hyperactivity Disorder
- Neuroendocrine regulation and behavior
- Neuroscience of respiration and sleep
- Hearing, Cochlea, Tinnitus, Genetics
- Stress Responses and Cortisol
- Child Abuse and Trauma
- Educational and Psychological Assessments
- Transcranial Magnetic Stimulation Studies
- Sirtuins and Resveratrol in Medicine
- Child and Adolescent Psychosocial and Emotional Development
- PARP inhibition in cancer therapy
- Neural dynamics and brain function
- Vestibular and auditory disorders
- Autophagy in Disease and Therapy
- Tracheal and airway disorders
- Obstructive Sleep Apnea Research
Army Medical University
2013-2024
Chongqing Medical University
2024
People's Hospital of Bishan District
2024
Daping Hospital
2016-2018
A close view of the paraventricular thalamus The is a relay station connecting brainstem and hypothalamic signals that represent internal states with limbic forebrain performs associative functions in emotional contexts. Zhu et al. found thalamic neurons multiple salient features sensory stimuli, including reward, aversiveness, novelty, surprise. nucleus thus provides context-dependent salience encoding. gates information contributes to sleep-wake cycle through its interactions cerebral...
Abstract Enhancement of wakefulness is a prerequisite for adaptive behaviors to cope with acute stress, but hyperarousal associated impaired behavioral performance. Although the neural circuitries promoting in stress conditions have been extensively identified, less known about circuit mechanisms constraining prevent hyperarousal. Here, we found that chemogenetic or optogenetic activation GAD2-positive GABAergic neurons midbrain dorsal raphe nucleus (DRN GAD2 ) decreased wakefulness, while...
High-frequency oscillatory activity in cognition-related neural circuits during wakefulness consistently induces the growth of dendritic spines and axonal terminals. Although these structural changes are essential for cognitive functions, it is hypothesized that if newly expanded structures fail to establish functional connections, they may become superfluous. Sleep believed facilitate reduction such redundant maintain homeostasis. However, mechanisms underlying this pruning process sleep...
Chronic primary insomnia (CPI) is the most prevalent sleep disorder worldwide. CPI manifests as difficulties in onset, maintaining sleep, prolonged latency, and daytime impairment often accompanied by cognitive problems such poor academic performance, attention, decreased memory. The popular explanation of hyperarousal or increased activities neurons. Rapid eye movement (REM) detected polysomnography (PSG) exhibits a positive relationship with brain homeostasis can be helpful for optimally...
Background: Response inhibition is a hallmark of executive function, which was detected impaired in various psychiatric disorders. However, whether insomnia disorder (ID) impairs response has caused great controversy. Methods: Using the auditory stop-signal paradigm coupled with event-related potentials (ERPs), we carried out this study to examine individuals ID presented deficits and further investigated neural mechanism correlated these deficits. Twelve 13 matched good sleepers (GSs) had...
Encoding of spatial information in the superficial layers medial entorhinal cortex (sMEC) involves theta-modulated spiking and gamma oscillations, as well spatially tuned grid cells border cells. Little is known about role arousal-promoting histaminergic system modification encoded sMEC vivo, how such histamine-regulated correlates with behavioral functions. Here, we show that histamine upregulates neural excitability a significant proportion neurons (16.32%, 39.18%, 52.94% at 30 μM, 300 3...
Objective: To evaluate the efficacy of Bailemian capsule combined with self-help cognitive behavioral therapy (CBTI-SH) in treatment chronic insomnia. Methods: Approved by Ethics Committee hospital, 60 patients insomnia were randomly divided into two groups, test group (Bailemian CBTI-SH) and control (CBTI-SH alone). Each contained 30 cases. After 4 weeks for therapy, sleep quality, mood adverse reactions evaluated diary, severity index scale (ISI), self-rating anxiety (SAS), depression...
Objective:To investigate the difference of therapeutic effect tinnitus patients with different types hearing curve.Method:Patients inclusion and exclusion criteria for treatment were studied retrospectively.Use SPSS 20.0 Chinese version software to collect data analysis.The was statistically significant when P<0.05.Result:A total 164 collected, most curve high frequency loss; according TEQ scoring grading method, in middle severity; The chi-square test showed that there no among first...