Background The histologic features of thrombus may differ according to the stroke subtypes. However, in acute reperfusion therapy, fibrin-specific thrombolytics are used based on assumption that all thrombi alike. Aims characteristics were compared between patients with different etiologies. Methods Between April 2010 and March 2012, we analyzed retrieved from during mechanical thrombectomy. All using component-specific stains such as Martius scarlet blue for fibrins immunostaining CD42b...

The acidic tumor environment has emerged as a crucial factor influencing the metastatic potential of cancer. We investigated effect an on acquisition properties in MCF7 breast cancer cells and explored inhibitory effects gallic acid. Prolonged exposure to culture conditions (over 12 weeks at pH 6.4) induced migratory invasive cells, accompanied by increased expression Matrix Metalloproteinase 2 9 (MMP2 MMP9, respectively), together with alterations E-cadherin, vimentin,...

To investigate the role of translocase outer mitochondrial membrane 40 (TOM40) in oral squamous cell carcinoma (OSCC) with aim identifying new biomarkers or potential therapeutic targets. TOM40 expression level OSCC was evaluated using datasets downloaded from The Cancer Genome Atlas (TCGA), as well clinical data. correlation between and clinicopathological parameters survival were analyzed TCGA. signaling pathways associated identified through gene set enrichment analysis. A network genes...

Despite advances in gastric cancer diagnosis and treatment, its prognosis remains poor owing to aggressive tumor progression metastasis. As understanding the relevant molecular mechanisms is essential effectively improve patient outcomes, we elucidated role of Kindlin-1 expression was analyzed 359 tissue samples provided by Kangnam Sacred Heart Hospital publicly available GSE datasets. showed significantly higher tissues than that normal tissues, high associated with prognosis. Further, mRNA...

Background The burden of valvular heart disease (VHD) is rising rapidly globally, accompanied by substantial geographical disparities. Although altitude may influence cardiovascular system, no community-based studies have yet explored altitudinal differences in VHD epidemiology. Objective This study aims to investigate the prevalence, spectrum and aetiology different areas. Methods We conducted two sequential echocardiography screening programmes Yunnan Province China included 5059 eligible...

It has been found that abnormal activation of the hedgehog (Hh) signaling pathway is involved in occurrence, invasion and metastasis malignant tumors. In addition, epithelial-mesenchymal transition (EMT) also performs an important function However, significance Hh EMT hepatocellular carcinoma (HCC) remains unknown. present study, expression Gli family zinc finger 1 (Gli-1) 2 (Gli-2), which are key transcriptional factors pathway, Twist E-cadherin, two EMT, was examined 42 patients with HCC...

Anaplastic thyroid cancer (ATC), a rare malignancy, accounts for only 5% of all cancers. However, it is the most aggressive form and has very poor prognosis. Increasing evidence suggests that ATC arises from papillary carcinoma (PTC). exact mechanism underlying this transformation remains unclear. In almost cases, originates within, but rarely outside, gland. Transformation metastatic PTC into within cervical lymph nodes extremely rare. report, we present case in 63-year-old male patient who...

Andrographolide, a natural compound isolated from Andrographis paniculata, has been reported to possess antitumor activity. In the present study, effect of andrographolide in human gastric cancer (GC) cells was investigated. Andrographolide induced cell death with apoptotic and non-apoptotic features. At low concentration, potentiated apoptosis reduction clonogenicity triggered by recombinant tumor necrosis factor-related apoptosis-inducing ligand (rhTRAIL). Exposure GC altered expression...

AIM: To evaluate the correlation bet�een level o��To o�� 18 F-fluoro-2-deoxyglucose ( F-FDG) uptake and glucose lucose transporter 1 (GLUT1) expression in colorectal adenocarcinoma (CRA)� . METHODS:Forty ��our patients �ith resected CRA preoperative F-FDG positron emission tomographycomputed tomography data �ere investigated this study.Comparison maximum standardized value (SUVmax) of lesion was made with GLUT1 by immunohistochemistry various clinicopathologic ��actors including tumor...

A glomus tumor is a benign vascular derived from the modified smooth muscle cells of body. The lesions develop as small blue-red nodules that are usually located in deep dermis or subcutis upper lower extremity. single most common site subungual region finger, but other sites include palm, wrist, forearm and foot. In present study, we report case 45-year‑old patient diagnosed with extradigital subcutaneous tissue elbow. Histopathological examination revealed was well-circumscribed nodule...

Programmed cell death ligand 1 (PD-L1) is an essential immune checkpoint protein implicated in evasion by malignant tumors. Overexpression of programmed (PD-1) and its PD-L1 associated with poor prognosis various types cancer. Recently, multiple advances have occurred the area cancer immunotherapy. Inhibiting ligation PD-1 has been major focus anti-tumor In diagnostic pathology, it become crucial to detect PD-L1+ tumor cases using a validated immunohistochemistry (IHC) approach. Preliminary...

Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent, number of cancer cells demonstrate TRAIL resistance. To date, various molecular targets leading to resistance have been elucidated by many researchers, but the mechanisms involved are still not fully understood. In present study, we obtained TRAIL-resistant from human hepatocellular carcinoma cell line HepG2 exposing recombinant (rhTRAIL), and determined mechanism for The selected...

We describe an epidermoid cyst arising from accessory spleen of the pancreas. A 56‑year‑old female with iron deficiency anemia presented dizziness. During clinical workup, a 2x4 cm‑sized mass was incidentally detected in tail pancreas computed tomography (CT) scan. Under diagnosis pancreatic cystic malignant tumor, distal pancreatectomy carried out. Grossly, lesion composed solid and portion. Microscopic analysis revealed that portion intrapancreatic cyst. An is extremely rare hence...

p16 and Ki‑67 immunohistochemistry can be used as an ancillary method for the diagnosis of squamous intraepithelial lesion (SIL) versus atrophic change atypical metaplasia. The aim present study was to evaluate efficacy these two immunohistochemical markers in accurate interpretation cervical biopsies correlate this data with human papilloma virus (HPV) infection status. included 103 formalin‑fixed punch cone biopsy samples, corresponding HPV DNA test data. Histopathological staining...

Nodular hyperplasia (nodular or multinodular goiter) is the most common form of thyroid disease. These nodules may undergo secondary changes in hemorrhages, calcification and cystic degeneration. However, osseous metaplasia with mature bone formation rarely occurs. The present study reports cases three female patients diagnosed as nodular formation. underwent right lobectomy, near total thyroidectomy thyroidectomy, respectively. clinical course following resection were unremarkable.

Primary liver sarcomatoid carcinoma (SC) is a rare and aggressive tumor exhibiting rapid growth high recurrence rate following resection. To date, there have been no reports of primary SC occurring simultaneously with hepatocellular (HCC). This the case report 54-year-old man cirrhosis due to hepatitis B virus (HBV) infection alcoholic hepatitis. The abdominal computed tomography magnetic resonance imaging revealed two distinct hepatic masses in background esophageal varices. Following...

Nasopharyngeal carcinoma (NPC) is a prevalent cancer in Southern China, North Africa, and Southeast Asia. The translocase of the outer membrane (TOM) 40 transporter mitochondrial proteins, involved ovarian cell growth. However, its role progression NPC still unclear. We found that TOM40 levels were upregulated tissues multiple lines. In addition, high expression tumor was associated with poor overall survival disease specific survival. knockdown lines inhibited their proliferation vitro...

A granular cell tumor (GCT) is a benign neoplasm of unclear histogenesis that generally believed to be nerve sheath origin. GCT not common and most often affects the tongue, skin soft tissue, although it may occur anywhere in body. We experienced case arose cecum 55-year-old man. The was removed by laparoscopic resection. In addition tumor, endoscopic examination revealed presence 5-mm-polyp descending colon multiple tiny polyps sigmoid rectum. Histological demonstrated cecal 1.5 cm x 1.0...

Ewing's sarcoma is a neoplasm of the undifferenciated small round cells, which generally affects bone and deep soft tissues children adolescents.We present case gastric sarcoma; 35-year-old female who had no symptoms.While she was at routine medical checkup, protruding mass in her antrum incidentally found on esophagogastroduodenoscopy.Endoscopic ultrasonogram showed submucosal same lesion laparosopic wedge resection done.Pathologic gross findings granular grape appearance tissue histoloigc...

Persistent hyperinsulinemic hypoglycemia is caused most commonly by an insulinoma in adults or nesidioblastosis neonates.In adults, a rare disorder characterized diffuse disseminated proliferation of islet cells.We recently encountered case adult.A 71-year-old m n wa s d i tt e u t o r g ra l weakness, abdominal pain, and mild dyspnea.The patient underwent subtotal gastrectomy for gastric adenocarcinoma two years ago.After 5 admission, the showed symptoms cold sweating, chilling, hypotension...