A5038250535- Liver Disease Diagnosis and Treatment
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Liver Disease and Transplantation
- Cardiac electrophysiology and arrhythmias
- Hepatitis B Virus Studies
- Liver physiology and pathology
- Atrial Fibrillation Management and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis C virus research
- Angiogenesis and VEGF in Cancer
- Organ Transplantation Techniques and Outcomes
- Cardiovascular Function and Risk Factors
- Genomic variations and chromosomal abnormalities
- Advanced Glycation End Products research
- Genomics and Chromatin Dynamics
- Sepsis Diagnosis and Treatment
- Heart Failure Treatment and Management
- Macrophage Migration Inhibitory Factor
- Climate Change and Health Impacts
- Congenital heart defects research
- Immune Response and Inflammation
- Axon Guidance and Neuronal Signaling
- Cancer Genomics and Diagnostics
- Toxin Mechanisms and Immunotoxins
Zhejiang University
2015-2024
National Clinical Research Center for Digestive Diseases
2024
First Affiliated Hospital Zhejiang University
2013-2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2011-2024
Jinan University
2024
Dalian Medical University
2024
Dali University
2019-2024
First Affiliated Hospital of Dalian Medical University
2024
Yunnan Center for Disease Control And Prevention
2024
Sir Run Run Shaw Hospital
2014-2023
Hemoglobin is released from lysed RBCs in numerous clinical settings. High mobility group box 1 (HMGB1) a nuclear and cytosolic DNA-binding protein injured cells that has been shown to play an important role inducing inflammation. Because both of these endogenous molecules are frequently present sites necrosis inflammation, we studied their interaction on the activation macrophages. We report this article hemoglobin HMGB1 synergize activate mouse macrophages release significantly increased...
Patients with acute-on-chronic liver failure (ACLF) represent a heterogeneous population. The aim of the study is to identify distinct groups according etiologies precipitating events. A total 405 ACLF patients were identified from 1,361 cirrhosis acute decompensation and categorized types insults. Clinical characteristics prognosis between hepatic group extrahepatic compared, performance prognostic models was tested in different groups. Two (hepatic-ACLF extrahepatic-ACLF) among...
Abstract Mesenchymal stem cell (MSC) transplantation alone may be insufficient for treatment of liver fibrosis because complicated histopathological changes in the liver. Given that miR‐122 plays an essential role by negatively regulating proliferation and transactivation hepatic stellate cells (HSCs), this study investigated whether modification can improve therapeutic efficacy adipose tissue‐derived MSCs treating fibrosis. MiR‐122‐modified AMSCs (AMSC‐122) were constructed through...
Abstract A recently developed pneumonia caused by SARS-CoV-2 has quickly spread across the world. Unfortunately, a simplified risk score that could easily be used in primary care or general practice settings not been developed. The objective of this study is to identify triage severe COVID-19 patients. All and critical adult patients with laboratory-confirmed on West campus Union Hospital, Wuhan, China, from 28 January 2020 29 February were included study. Clinical data laboratory results...
MicroRNAs (miRNAs) have been shown to complicated implications in the pathogenesis of Parkinson's disease (PD). However, role miR-29c and underlying mechanism development PD remain not well understood. In this work, MPTP-treated mice or MPP+ -intoxicated SH-SY5Y cells were established as an vivo vitro model. Then specific agomir was employed examine its biological function on progress. We found that down-expressed but SP1 high-expressed substantia nigra pars compacta (SNpc) MPTP-induced...
Chronic HBV infection (CHB) can lead to acute-on-chronic liver failure (HBV-ACLF) characterized by high mortality.This study aimed reveal ACLF-related proteomic alterations, from which protein based diagnostic and prognostic scores for HBV-ACLF were developed.Methods: Ten healthy controls, 16 CHB, 19 according COSSH (Chinese group on the of severe hepatitis B) criteria enrolled obtain comprehensive portrait related initiation progression.Potential markers further selected organ specificity...
Hepatitis B virus (HBV) causes hepatitis, which progresses to fatal liver diseases and remains a global health problem. Current treatments for chronic hepatitis are unable cure hepatitis. Thus, new antiviral drugs must be developed. In this study, the viral inhibition effects of dandelion taraxasterol were assessed in HepG2.2.15 cell line. Taraxacum officinale F.H.Wigg. (compositae) with English name is used as traditional herb disorders common agent. Taraxasterol one active compounds...
Background. Abnormal lipid metabolism contributes to the pathogenesis of diabetes, but it is uncertain whether plays a role in development diabetic nephropathy (DN). While rapamycin was shown prevent DN streptozotocin (STZ)-induced rats our previous studies, unknown if intervenes with metabolism.
Bioartificial liver provides a combination of three-dimensional support, matrix interactions, and extracellular cues to create bio-mimic microenvironment for maintaining hepatic-specific functions cells in vitro. However, its transformal metabolic are not yet satisfactory clinic application. In this study, hepatoma-derived C3A were co-cultured with human placental mesenchymal stem (hPMSC) microspheres placed fluidized bioreactor. The secretion albumin urea, the expression metabolizing...
Abstract Background and Aim Patients with acute‐on‐chronic liver failure ( ACLF ) represent a complex population differential prognosis. The aim of the study was to categorize according severity underlying chronic diseases. Methods A total 540 patients were recruited, including 127 prior decompensated cirrhosis 413 without decompensation PD 193 hepatitis 220 compensated cirrhosis. clinical characteristics prognosis subgroups compared. C ox proportional hazard model multinominal logistic...
Bortezomib is a frequently used chemotherapeutic drug for the treatment of multiple myeloma and other nonsolid malignancies. Accumulating evidence has demonstrated that bortezomib-induced persistent pain serves as most frequent reason discontinuation.The von Frey test was performed to evaluate neuropathic behavior, real-time quantitative reverse transcription polymerase chain reaction, chromatin immunoprecipitation, western blot, immunohistochemistry, small interfering RNA were explore...
Background/Aims: C1q and tumour necrosis factor-related protein 1 (CTRP1) possesses anti-atherogenic anti-inflammatory effects. This study investigated whether the CTRP1 levels in plasma epicardial adipose tissue (EAT) were associated with congestive heart failure (CHF) to disclose possible molecular mechanisms. Methods: Plasma samples obtained from subjects or without CHF. of measured by ELISA. The mRNA inflammatory cytokines detected RT-PCR. CTRP1, aldosterone synthase (CYP11B2)...
A considerable proportion of chronic hepatitis B (CHB) or virus (HBV)-related cirrhotic patients develop acute-on-chronic liver failure (ACLF) with high short-term mortality. It remains difficult to accurately predict prognosis in ACLF patients. The aim the study is a new prognostic model by assessing objective variables.A total 432 HBV-ACLF were recruited into retrospective observational cohort including one training and validation cohort. Cox proportional hazard analysis was performed...
Abstract Aims Left bundle branch pacing (LBBP) has been shown to better maintain electrical synchrony compared with right ventricular (RVP), but little is known about its impact on mechanical synchrony. This study investigates whether LBBP preserves left (LV) synchronicity and function RVP. Methods results Sixty patients indication for bradycardia were included: (n = 31) RVP 29). Echocardiography was performed before shortly after pacemaker implantation at 1-year follow-up. The lateral...
Objectives A lower relative handgrip strength (HGS) may disrupt metabolic homeostasis and then lead to syndrome (MetS). There is a paucity of longitudinal studies examine whether HGS at baseline linked incident MetS. Thus, the purpose present study was explore association between new-onset Design This an observational research. nationally representative sample population in China. Participants total 3350 subjects without MetS were selected for analysis study. Data are from China Health...
Summary Aim To investigate the effect of chronic H 1‐antihistamine treatment on seizure susceptibility after drug withdrawal in nonepileptic rats and to further study its relation glutamine synthetase ( GS ), which is key enzyme for glutamate metabolism gamma aminobutyric acid GABA ) synthesis. Methods After from a 2‐week with diphenhydramine or pyrilamine, was determined by amygdaloid kindling pentylenetetrazol model; meanwhile, expression activity analyzed. The glutamine, glutamate,...
Background: Lipocalin 2 (LCN2), a protein primarily produced by hepatocytes, is highly upregulated under various conditions that induce cellular stress, such as intoxication, infection or inflammation. However, the precise biological functions and underlying mechanisms of LCN2 in hepatocytes remains unknown. Methods: Hepatocyte stress was successfully induced treating Huh7 cells with interleukin-1β (IL-1β). Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF-α) levels were measured IL-1β...
During hepatitis B virus (HBV) infection, three viral envelope proteins of HBV are overexpressed in the endoplasmic reticulum (ER). The large S protein (LHBs) and truncated middle (MHBst) have been documented to play roles regulating host gene expression contribute hepatic disease development. As a predominant at ultrastructural level biopsy samples taken from viremic patients, role (MHBs) remains be understood despite its high immunogenicity. When we transfected hepatocytes with an enhanced...