A5067830168- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- ECG Monitoring and Analysis
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiomyopathy and Myosin Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Neurological disorders and treatments
- Transplantation: Methods and Outcomes
- Ion channel regulation and function
- Mechanical Circulatory Support Devices
- Pericarditis and Cardiac Tamponade
- Surgical Simulation and Training
- Infective Endocarditis Diagnosis and Management
- Radiation Dose and Imaging
- Viral Infections and Immunology Research
- Nosocomial Infections in ICU
- Sarcoidosis and Beryllium Toxicity Research
KU Leuven
2016-2025
Universitair Ziekenhuis Leuven
2017-2025
University of Rochester Medical Center
2017
Hospital Universitario Araba
2015
Pitié-Salpêtrière Hospital
2014
Assistance Publique – Hôpitaux de Paris
2014
Assaf Harofeh Medical Center
2014
Benha University
2014
Hacettepe University
2014
Centro Cardiologico Monzino
2014
Background Drug safety precautions recommend monitoring of the corrected QT interval. To determine which correction formula to use in an automated ‐monitoring algorithm our electronic medical record, we studied rate performance different formulae and their impact on risk assessment for mortality. Methods Results All electrocardiograms ( ECG s) patients >18 years with sinus rhythm, normal QRS duration <90 beats per minute (bpm) University Hospitals Leuven (Leuven, Belgium) during a...
Abstract Recent studies on spontaneous fluctuations in the functional MRI blood oxygen level‐dependent (BOLD) signal awake healthy subjects showed presence of coherent among functionally defined neuroanatomical networks. However, significance these BOLD remains poorly understood. By means 3 T MRI, we demonstrate absent cortico‐thalamic connectivity (i.e. between posterior cingulate/precuneal cortex and medial thalamus), but preserved cortico‐cortical within default network a case vegetative...
BackgroundEarly results of the Micra Investigational Device Exemption (IDE) study and Post-Approval Registry (PAR) demonstrated excellent safety efficacy performance; however, intermediate-term across a large patient population in real-world setting have not been evaluated.ObjectivesWe report updated performance transcatheter pacemaker from worldwide PAR compare it with IDE as well transvenous historical control.MethodsThe objective analysis was system- or procedure-related major...
BackgroundFirst-in-man studies of leadless pacemakers have demonstrated high rates implant success, and safety efficacy objectives were achieved. Outside the investigational setting, there are concerns, particularly over cardiac effusion perforation, device dislodgement, infection, telemetry, battery issues.ObjectiveThe acute performance Micra transcatheter pacemaker from a worldwide Post-Approval Registry is reported.MethodsThe registry an ongoing prospective single-arm observational study...
This study reports on the performance of a leadless ventricular pacemaker with automated, enhanced accelerometer-based algorithms that provide atrioventricular (AV) synchronous pacing. Despite many advantages, pacemakers are currently only capable single-chamber The prospective MARVEL 2 (Micra Atrial tRacking using Ventricular accELerometer 2) assessed an algorithm downloaded to Micra for up 5 h in patients AV block. primary efficacy objective was demonstrate superiority (VDD) pacing versus...
Abstract Background and Aims Prior reports have demonstrated a favourable safety efficacy profile of the Micra leadless pacemaker over mid-term follow-up; however, long-term outcomes in real-world clinical practice remain unknown. Updated performance VR through five years from worldwide post-approval registry (PAR) was assessed. Methods All PAR patients undergoing implant attempts were included. Endpoints included system- or procedure-related major complications system revision rate for any...
To test the usefulness of procalcitonin serum level for reduction antibiotic consumption in intensive care unit patients.Single-center, prospective, randomized controlled study.Five units from a tertiary teaching hospital.All consecutive adult patients hospitalized >48 hrs during 9-month period.Procalcitonin was obtained all suspected developing infection either on admission or stay. The use antibiotics more less strongly discouraged recommended according to Muller classification. Patients...
Deranged energy metabolism contributes to the pathophysiology of heart failure (HF). Recent studies showed diminished free fatty acid (FFA) oxidation in experimental HF models with a shift towards ketone bodies. However, conflicting clinical data on FFA and limited knowledge body human mandate additional metabolic profiling studies. We, therefore, investigated cardiac uptake FFAs bodies (β-hydroxybutyrate acetoacetate) patients reduced ejection fraction (HFrEF) or aortic stenosis...
Recently a new risk marker for drug-induced arrhythmias called index of cardio-electrophysiological balance (iCEB), measured as QT interval divided by QRS duration, was evaluated in an animal model. It hypothesized that iCEB is equivalent to the cardiac wavelength λ (λ = effective refractory period (ERP) x conduction velocity) and increased or decreased value would potentially predict susceptibility TdP non-TdP mediated VT/VF, respectively.First, correlation between ERP invasively measuring...
Endurance sports activities have been associated with the development of atrial fibrillation (AF). Pulmonary vein isolation (PVI) by means radiofrequency catheter ablation has established as an effective treatment for AF. The aim present study was to analyse efficacy AF in athletes.We compared procedural outcome and median term follow-up 94 consecutive athletes (>3 h sports/week ≥ 10 years or 1500 lifetime) who underwent PVI (94% men, 51 ± 8 years, 87% paroxysmal AF, left (LA) diameter 40...
There is limited information on what clinical factors are associated with the development of pericardial effusion after leadless pacemaker implantation. We sought to determine predictors and develop a risk score for in patients undergoing Micra implantation attempt.Patients (n = 2817) implant attempt from global trials were analysed. Characteristics compared between without (including cardiac perforation tamponade). A was developed 18 pre-procedural variables using lasso logistic regression....
Abstract Background While prior Micra trials demonstrated a high implant success rate and favorable safety efficacy results, changes in populations over time is not well studied. The objective of this analysis was to report the performance European Middle Eastern patients compare Investigational Device Exemption (IDE) Post Approval Registry (PAR) studies. Methods prospective, single‐arm Acute Performance (MAP EMEA) registry designed further study from EMEA. primary endpoint characterize...
Abstract The second generation of transcatheter pacing systems, called Micra AV, can provide atrioventricular (AV) synchronous via a new algorithm relying on sensing mechanical atrial contraction. Several novel programming parameters were introduced to enable AV pacing, including an A3 window and A4 as well conduction mode switch activity switch. In addition several automated features, manual optimization some the is key improving synchrony. A solid knowledge features their essential for...
BackgroundThe MARVEL (Micra Atrial TRacking Using a Ventricular AccELerometer) 2 study assessed the efficacy of atrioventricular (AV) synchronous pacing with Micra leadless pacemaker. Average synchrony (AVS) was 89.2%. Previously, low amplitude Micra-sensed atrial signal (A4) observed to be factor AVS.ObjectiveThe purpose this identify predictors A4 and high AVS.MethodsWe analyzed 64 patients enrolled in who had visible P waves on electrocardiogram for assessing 40 third-degree AV block AVS...
Abstract Background With its steerable transcatheter delivery system, the Micra can be deployed in nonapical positions within right ventricle, potentially allowing reduction of paced QRS width. We sought to evaluate safety and long‐term performance ventricular outflow tract (RVOT) pacing using system (TPS). also compared between RVOT, mid‐septal, apical implant positions. Methods All patients who underwent a TPS implantation at University Hospitals Leuven were enrolled this observational...
Clinical guidelines on implantable cardioverter defibrillator (ICD) therapy changed significantly in the last decades with potential inherent effects efficacy. We aimed to study rates time and association between therapies mortality.All patients receiving an ICD, primary secondary prevention, were included a single-center retrospective registry. Information first appropriate inappropriate was documented. Dates of implant divided P1: 1996-2001, P2: 2002-2008, P3: 2009-2014.A total 727...
Combination antibiotic therapy for ventilator associated pneumonia (VAP) is often used to broaden the spectrum of activity empirical treatment. The relevance such synergy commonly supposed but poorly supported. aim present study was compare clinical outcome and course biological variables in patients treated a VAP, using monotherapy with beta-lactam versus combination therapy.Patients VAP were prospectively randomised receive either cefepime alone or association amikacin levofloxacin....
Abstract Introduction The MARVEL study demonstrated at a single time point that accelerometer (ACC)‐based atrial sensing improves atrioventricular (AV) synchrony (AVS) in patients with AV block and Micra pacemaker (Medtronic, Minneapolis, MN, USA). purpose of the Evolve substudy was to assess performance over time. Methods This prospective single‐center compared AVS ACC signals two visits ≥6 months apart. Custom software temporarily downloaded into each visit measured during 30 min rest....
Abstract Aims Left bundle branch pacing (LBBP) has been shown to better maintain electrical synchrony compared with right ventricular (RVP), but little is known about its impact on mechanical synchrony. This study investigates whether LBBP preserves left (LV) synchronicity and function RVP. Methods results Sixty patients indication for bradycardia were included: (n = 31) RVP 29). Echocardiography was performed before shortly after pacemaker implantation at 1-year follow-up. The lateral...