A5062708421- Cardiovascular Function and Risk Factors
- Respiratory Support and Mechanisms
- Mechanical Circulatory Support Devices
- Hemodynamic Monitoring and Therapy
- Cardiac Arrest and Resuscitation
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Health and Disease Prevention
- Cardiac Imaging and Diagnostics
- Sepsis Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Intensive Care Unit Cognitive Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Structural Anomalies and Repair
- COVID-19 Clinical Research Studies
- Diabetes Management and Research
- Heart Rate Variability and Autonomic Control
- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Ultrasound in Clinical Applications
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac Valve Diseases and Treatments
- Acute Kidney Injury Research
- Blood Pressure and Hypertension Studies
- Nosocomial Infections in ICU
- Cardiac electrophysiology and arrhythmias
University of Liège
2012-2021
Centre Hospitalier Universitaire de Liège
2012-2021
Baxter (United States)
2017
University of Göttingen
2017
Imation (United States)
2010
Vrije Universiteit Amsterdam
2002
To test the usefulness of procalcitonin serum level for reduction antibiotic consumption in intensive care unit patients.Single-center, prospective, randomized controlled study.Five units from a tertiary teaching hospital.All consecutive adult patients hospitalized >48 hrs during 9-month period.Procalcitonin was obtained all suspected developing infection either on admission or stay. The use antibiotics more less strongly discouraged recommended according to Muller classification. Patients...
Ventilator-associated pneumonia diagnosis remains a debatable topic. New definitions of ventilator-associated conditions involving worsening oxygenation have been recently proposed to make surveillance events possibly linked as objective possible. The the study was confirm effect subglottic secretion suctioning on prevalence and assess its concomitant impact antibiotic use.Randomized controlled clinical trial conducted in five ICUs same hospital.Three hundred fifty-two adult patients...
The aim of this study was to test whether the simple ratio right ventricular (RV) end-systolic pressure (Pes) stroke volume (SV), known as effective arterial elastance (Ea), provides a valid assessment pulmonary load in case embolism- or endotoxin-induced hypertension. Ventricular pressure-volume (PV) data (obtained with conductance catheters) and invasive flow waveforms were simultaneously recorded two groups six pure Pietran pigs, submitted either embolism (group A) endotoxic shock B)....
Peak first derivative of femoral artery pressure (arterial dP/dtmax) derived from fluid-filled catheter remains questionable to assess left ventricular (LV) contractility during shock. The aim this study was test if arterial dP/dtmax is reliable for assessing LV various hemodynamic conditions such as endotoxin-induced shock and catecholamine infusion.Ventricular pressure-volume data obtained with a conductance invasive were continuously recorded in 6 anaesthetized mechanically ventilated...
Functional residual capacity (FRC) measurement is now available on new ventilators as an automated procedure. We compared FRC, static thoracopulmonary compliance (Crs) and PaO2 evolution in experimental model of acute respiratory distress syndrome (ARDS) during a reversed, sequential ramp procedure positive end-expiratory pressure (PEEP) changes to investigate the potential interest combined FRC Crs such pathologic state. ARDS was induced by oleic acid injection six anesthetised pigs. were...
Background Protective lung ventilation is recommended in patients with acute respiratory distress syndrome ( ARDS ) to minimize additional injuries the lung. However, hypercapnic acidosis resulting from at lower tidal volume enhances pulmonary hypertension and might induce right ventricular RV failure. We investigated if extracorporeal veno‐venous CO 2 removal therapy could have beneficial effects on circulation function. Methods This study was performed an experimental model of obtained...
Objective: To investigate the effects of endotoxin infusion on right ventricular (RV) systolic function and mechanical efficiency. Methods: Six anesthetized pigs (Endo group) received a 0.5 mg/kg over 30 min were compared with six other (Control receiving placebo for 5 h. RV pressure–volume (PV) loops obtained by conductance catheter technique pulmonary artery flow pressure measured high-fidelity transducers. Results: adaptation to increased afterload during early phase endotoxin-induced...
Pulse wave velocity measurements are an indicator of arterial stiffness and possible cardiovascular dysfunction. It is usually calculated by measuring the pulse transit time (PTT) over a known distance through arteries. In animal studies, reliable PTT measures can be obtained using two pressure catheters. However, such direct, invasive methods undesirable in clinical settings. A less alternative measure arrival (PAT), between Q-wave electrocardiogram (ECG) foot beats waveform at one...
Abstract Background The diagnostic ability of computer-based methods for cardiovascular system (CVS) monitoring offers significant clinical potential. This research tests the applicability a newly improved method proof concept case tracking changes in important hemodynamic indices due to influence acute pulmonary embolism (APE). Methods Hemodynamic measurements from porcine model APE were used validate method. Of these measurements, only those that are clinically available or inferable...
Precise assessment of left ventricular (LV) contractility during veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support is crucial. However, changes in loading conditions may mask LV function when assessed with load-dependent parameters. We compared end-systolic elastance (Ees, mm Hg/ml), the reference load-independent parameter contractility, ejection fraction (LVEF) two patients. The first patient was a 54-year-old supported femoro-femoral VA-ECMO for cardiogenic shock....
The aim of this study was to evaluate the effect BM-573 [<i>N</i>-terbutyl-<i>N</i>′-[2-(4′-methylphenylamino)-5-nitro-benzenesulfonyl]urea], a dual thromboxane A<sub>2</sub> synthase inhibitor and receptor antagonist, on hemodynamic response acute pulmonary embolism. Six anesthetized pigs were infused with placebo (placebo group) compared six other receiving continuous infusion (BM group). Pulmonary embolization 0.3 g/kg autologous blood clots carried out 30 min after start infusion. Right...
The pandemic of COVID-19 led to a dramatic situation in hospitals, where staff had deal with huge number patients respiratory distress. To alleviate the workload radiologists, we implemented an artificial intelligence (AI) - based analysis named CACOVID-CT, automatically assess disease severity on chest CT scans obtained from those patients. We retrospectively studied 476 admitted at University Hospital Liege disease. quantified percentage affected lung area (% AA) and score (total CT-SS)....
Fluid therapy is frequently used to manage acute circulatory failure. This aims restore cardiac output by fluid administration, which increases the quantity of in circulation. However, it has been shown be effective only certain cases, leading need for indices responsiveness. Total stressed blood volume recently such an index current methods determine this parameter require specific procedures. In work, a more straightforward method developed using data available intensive care unit. A...
Objective: It was investigated whether pharmacologically induced changes in right ventricular contractility can be detected by a so-called "single-beat" method that does not require preload reduction. Design: Prospective animal research. Setting: Laboratory at large university medical center. Subjects: Eight anesthetized pigs. Interventions: End-systolic elastance values obtained recently proposed single-beat (Eessb) were compared with those using the reference multiple-beat (Eesmb)....
Maximal left ventricular (LV) hydraulic power output (PWR max ), corrected for preload as PWR /(V ed ) β (where V is the end-diastolic volume and a constant coefficient), an index of LV contractility. Whereas preload-adjusted maximal (PAMP) usually calculated with = 2, there uncertainty about optimal value (β 1 normal 2 dilated LV). The aim this work to study determining factors β. data set consisted 245 recordings (steady state vena cava occlusion) in 10 animals ischemic heart pig model....
Glycaemic control has been shown to improve outcome in critically ill patients, but hard achieve a safe and effective manner. This paper presents the preliminary results of 8 patients controlled at University Hospital Liège under STAR-Liège, an insulin-only version model-based STAR glycaemic controller framework. Clinical data is compared with virtual trial simulations outcomes for STAR-Liège protocol, standard care protocol this intensive unit, assess safety, performance, compliance new...
Abstract Low flow extracorporeal veno‐venous CO 2 removal (ECCO R) therapy is used to remove while reducing ventilation intensity. However, the use of this technique limited because efficiency and potential beneficial effects on pulmonary hemodynamics are not precisely established. Moreover, requires anticoagulation that may induce severe complications in critically ill patients. Therefore, our study aimed at determining precise extraction its right ventricular (RV) afterload, comparing...
Abstract Background There are limited data on Coronavirus disease 2019 (COVID-19) in solid organ transplant patients, especially heart recipients, with only a few case reports and series described so far. Heart recipients may be at particular high risk due to their comorbidities immunosuppressed state. Case presentation This report describes the clinical course challenging management of early COVID-19 infection two who tested positive for SARS-CoV-2 virus perioperative period procedure. The...
We investigated the effects of a dual thromboxane (TX)A2 synthase inhibitor and TXA2 receptor antagonist (BM-573) on right ventricular-arterial coupling in porcine model endotoxic shock. Thirty minutes before onset 0.5 mg/kg endotoxin infusion, six pigs (Endo group) received an infusion with placebo solution, other (Anta BM-573. Right ventricular pressure–volume loops were obtained by conductance catheter technique. The slope (Ees) end-systolic relationship its volume intercept at 25 mmHg...