A5041424887- Inflammatory mediators and NSAID effects
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Coagulation and Thrombosis Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- COVID-19 Clinical Research Studies
- Platelet Disorders and Treatments
- SARS-CoV-2 detection and testing
- Synthesis and biological activity
- Estrogen and related hormone effects
- Enzyme function and inhibition
- Blood properties and coagulation
- Synthesis and Catalytic Reactions
- Analytical Methods in Pharmaceuticals
- Eicosanoids and Hypertension Pharmacology
- Receptor Mechanisms and Signaling
- Nanoparticles: synthesis and applications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cardiac Imaging and Diagnostics
- Chronic Myeloid Leukemia Treatments
- Cardiac electrophysiology and arrhythmias
- Phenothiazines and Benzothiazines Synthesis and Activities
- Extracellular vesicles in disease
University of Namur
2015-2024
Namur Research Institute for Life Sciences
2014-2023
Access
2010-2021
Access to Wholistic and Productive Living Institute
2010-2021
Clinique Saint Pierre
2021
Clinique Saint-Joseph
2021
Directorate-General for Health and Food Safety
2018
Pharmac
2004-2017
CHU Dinant Godinne UCL Namur
2012
University of Florence
2008
Summary Due to low bioavailability and high inter-individual variability, monitoring of dabigatran may be required in specific situations prevent the risk bleedings or thrombosis. The aim study was determine which coagulation assay(s) could used assess impact dabig-atran on secondary haemostasis. Dabigatran spiked at concentrations ranging from 4.7 ng/ml 943.0 pooled citrated human platelet-poor plasma. following clotting assays were performed: prothrombin time (PT); activated partial...
A phase 3 trial with ponatinib in patients chronic myeloid leukemia (CML) was interrupted due to an important increase of vascular occlusive events. similar risk also suspected nilotinib, another BCR-ABL tyrosine kinase inhibitor (TKI) used CML.To assess the events CML treated by new generations TKIs and provide overall assessment clinical benefit.Two independent reviewers selected studies from PubMed, Scopus, Cochrane library database their inception October 21, 2014. Abstracts published...
Several studies reported on the humoral response in subjects having received BNT162b2 mRNA COVID-19 vaccine. However, data kinetics of antibodies 3 months post-vaccination are currently lacking and important to drive future vaccination strategy. The CRO-VAX HCP study is an ongoing multicentre, prospective interventional designed assess antibody a population healthcare professionals who had two doses Two hundred individuals underwent blood drawn within 2 days before first vaccine dose....
Apixaban does not require monitoring nor frequent dose adjustment. However, searching for the optimal individual patient may be useful in some situations. Moreover, there is a need clinicians to know whether coagulation assays are influenced by apixaban use. The aim of this study was determine which assay could used assess impact on haemostasis and provide good laboratory recommendations accurate interpretation assays. spiked at concentrations ranging from 5 500 ng/mlin platelet-poor plasma....
Summary Possibilities to monitor rivaroxaban therapy could be useful in certain circumstances. Prothrombin time (PT) or chromogenic anti-Xa assays such as the Biophen Direct Factor Xa Inhibitor® (DiXaI) have been proposed estimate concentrations but are mainly based on vitro studies. The study aim was compare PT and DiXaI® measurements with liquid chromatography-tandem mass spectrometry (LC-MS/MS) plasma samples from patients treated Xarelto®. Fifty-two were included. performed using...
The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serological tests is massive. external validation their performance needed before use in clinical routine practice. Our study aims at assessing the analytical and two enzyme-linked immunosorbent assay detecting antibodies directed against virus nucleocapsid protein: NovaLisa SARS-CoV-2 immunoglobulin G (IgG), A (IgA), M (IgM) test (NovaTec) allowing a separate detection each antibody Platelia Total Ab (Bio-Rad)...
The evaluation of the neutralizing capacity anti-SARS-CoV-2 antibodies is important because they represent real protective immunity. In this study we aimed to measure and compare (NAbs) in COVID-19 patients vaccinated individuals. One-hundred fifty long-term samples from 75 were analyzed with a surrogate virus neutralization test (sVNT) compared six different SARS-CoV-2 serology assays. agreement between sVNT pseudovirus VNT (pVNT) results was found be excellent (i.e., 97.2%). NAb response...
(1) Background: The detection of SARS-CoV-2 RNA in nasopharyngeal samples through real-time reverse transcription-polymerase chain reaction (RT-PCR) is considered the standard gold method for diagnosis infection. Antigen (AD) tests are more rapid, less laborious, and expensive alternatives but still require clinical validation. (2) Methods: This study compared performance five AD tests, including four rapid (RAD) (biotical, Panbio, Healgen, Roche) one automated test (VITROS). For that...
Abstract Objectives Faced with the COVID-19 pandemic and its impact on availability quality of both therapeutic diagnostic methods, Belgian authorities have decided to launch a procedure for additional evaluation performance serological tests offered sale national territory. This has been proposed double aim: (1) an in-depth verification analytical clinical performances presented by manufacturer (2) economy scale in terms centralized validation all laboratories using subject evaluation....
Several studies have described the long-term kinetics of anti-SARS-CoV-2 antibodies but follow-up data, i.e., >6 months, are still sparse. Additionally, literature is inconsistent regarding waning effect serological response. The aim this study was to explore temporal dynamic changes immune response after SARS-CoV-2 infection in hospitalized and non-hospitalized symptomatic patients over a period 10 months. Six different analytical kits for antibody detection were used. Positivity rates,...
Rapid antigen detection (RAD) tests are commonly used for the diagnosis of SARS-CoV-2 infections. However, with continuous emergence new variants concern (VOC), presenting various mutations potentially affecting nucleocapsid protein, analytical performances these assays should be frequently reevaluated. One hundred and twenty samples were selected tested both RT-qPCR six commercial RAD that sold in Belgian pharmacies. Of these, direct whole-genome sequencing identified strains present 116...
IntroductionAn increase evasion of the SARS-CoV-2 virus towards vaccination strategies and natural immunity has been rapidly described notably due to mutations in spike receptor binding domain N-terminal domain.Material methodsParticipants CRO-VAX HCP study who received bivalent booster were followed at 6 months. A pseudovirus‐neutralization test was used assess neutralization potency antibodies against D614G, Delta, BA.1, BA.5, XBB.1.5, BA.2.86, FL.1.5.1, JN-1.ResultsThe neutralizing...
Blood coagulation starts immediately after damage to the vascular endothelium. This system is essential for minimizing blood loss from an injured vessel but also contributes thrombosis. Although it has long been thought that intrinsic pathway not important clotting in vivo, recent data obtained with genetically altered mice indicate contact phase proteins seem be thrombus formation. We show recombinant Ixodes ricinus inhibitor (Ir-CPI), a Kunitz-type protein expressed by salivary glands of...
Silver nanoparticles (Ag NPs) are increasingly used in biomedical applications because of their large antimicrobial spectrum. Data the literature on ability Ag NPs to perform desired function without eliciting undesirable effects blood elements very limited and contradictory. We studied impact erythrocyte integrity, platelet coagulation. Erythrocyte integrity was assessed by spectrophotometric measurement haemoglobin release. Platelet adhesion aggregation determined light transmission...