A5088227032- Hemophilia Treatment and Research
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Venous Thromboembolism Diagnosis and Management
- Blood properties and coagulation
- Vitamin K Research Studies
- Liver Disease and Transplantation
- Heparin-Induced Thrombocytopenia and Thrombosis
- Atrial Fibrillation Management and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Clinical Laboratory Practices and Quality Control
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Liver Disease Diagnosis and Treatment
- Intramuscular injections and effects
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Chronic Myeloid Leukemia Treatments
- Hemostasis and retained surgical items
- Hemoglobinopathies and Related Disorders
- Blood transfusion and management
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- vaccines and immunoinformatics approaches
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood donation and transfusion practices
- Protein purification and stability
- Economic and Financial Impacts of Cancer
Centre Hospitalier Universitaire de Clermont-Ferrand
2016-2025
Université Clermont Auvergne
2012-2024
Centre de Recherche en Nutrition Humaine d'Auvergne
2016-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2016-2024
Unité de Nutrition Humaine
2016-2024
Laboratoire de Météorologie Physique
2020
Sorbonne Université
2019-2020
Hôpital Saint-Antoine
2019-2020
Assistance Publique – Hôpitaux de Paris
2019
Biologie Labor
2018
A rapid lateral flow immunoassay (LFIA) (STic Expert® HIT), recently developed for the diagnosis of heparin-induced thrombocytopenia (HIT), was evaluated in a prospective multicentre cohort 334 consecutive patients. The risk HIT estimated by 4Ts score as low, intermediate and high 28·7%, 61·7% 9·6% patients, respectively. Definite diagnosed 40 patients (12·0%) with positive results on both enzyme-linked immunosorbent assay (Asserachrom® HPIA IgG) serotonin release assay. inter-reader...
The different stages of hemostasis (i.e., primary hemostasis, coagulation and fibrinolysis) are involved in the early atherothrombosis steps. aim this study was to investigate effect epicatechin, a major flavonoid compound, on phenotype using clinically relevant vitro global assays that mimic complexity vivo systems. Plasma samples from 10 healthy volunteers were spiked with increasing concentrations epicatechin (1 100 μM). Epicatechin fibrinolysis assessed by measuring platelet aggregation...
Abstract Background and Aims Cirrhosis significantly changes all hemostasis steps. Recent studies suggest that cirrhosis is associated with a coagulopathy leading to hypercoagulable state. The underlying mechanisms are not fully understood, but protein C deficiency probably major determinant of this phenotype. aim study was compare the results thrombin generation assays performed addition thrombomodulin or activated assess effect by‐passing activation step in cirrhotic patients healthy...
Abstract Cardiovascular diseases (CVDs) are a major issue in aging patients with hemophilia (PWHs). Antithrombotic agents widely used the general population for CVD treatment, but this recommendation is not fully applicable to PWHs. To improve treatment strategies, prospective case–control study (COCHE) that analyzed management and follow-up (2 years/patient) PWHs was performed France from 2011 2018. In total, 68 (median age: 65 years [39–89]; 48 mild, 10 moderate, severe hemophilia) were...
Background The Hemophilia Functional Ability Scoring Tool (Hemo-FAST), consisting of a patient-reported outcome (PRO) part and clinician-reported (ClinRO) part, was developed as rapid effective tool to assess functional mobility in clinical practice. This study (NCT04731701) aimed validate the psychometric properties Hemo-FAST for assessment joint health people with haemophilia (PwH). Methods PwH A or B aged ≥18 years completed questionnaires including PRO short-form 36 survey (SF-36) during...
Available data on the potential use of thrombin generation (TG) assays in clinical practice is promising but larger studies involving several centers are needed to confirm this added-value for purposes. The objective evaluation was assess analytical performances ST Genesia using STG-ThromboScreen, STG-BleedScreen, and STG-DrugScreen reagents across three support its multicenter studies. Repeatability reproducibility have been evaluated commercial plasmas quality control (QC) samples....
ABSTRACT Background Haemophilia management aims to prevent bleeding and preserve joint function. Changes in patients’ health may influence physicians' decisions adjust treatment. The Joint Health Score (HJHS) Early Arthropathy Detection with Ultrasound (HEAD‐US) score assess but are not routinely used. Aim To evaluate whether systematic examination HJHS and/or HEAD‐US had an impact on treatment France, using final data from the A‐MOVE study. Methods (NCT04133883) was a 12‐month prospective,...
ABSTRACT Introduction There are few data on healthcare resource use and related costs of French haemophilia A (HA) B (HB) patients. Aims This study aimed to describe the profile HA HB patients, current disease management, clinical burden costs. Methods Data patients all ages alive 1/1/2022 were extracted from nationwide claims database (SNDS). Patients divided into four treatment groups: on‐demand or prophylaxis with without inhibitors. Haemophilia compared a control group (ratio 1:3)...
Centrifugation is a critical step in sample preparation and accounts for an important part of turnaround time. This further hemostasis, which requires low platelet count to produce reliable results. For automated laboratories, centrifugation can represent bottleneck thus shorter time would benefit tube flow We compared rapid protocol (4000 g 4 min) with the recommended (2200 15 at two different centers, after one or cycles. The effect each was assessed on every verify capacity yield...
Summary Antibodies (inhibitors and non-neutralising antibodies [NNA]) directed against factor VIII (FVIII) remain the main iatrogenic complication in haemophilia A (HA) patients. Inhibitors reduce FVIII procoagulant properties, whereas NNA are non-functional epitopes. poorly studied their prevalence, epitope specificity physiopathology inadequately defined. The aim of this study was first to evaluate prevalence a French retrospective multicentric series 210 patients without inhibitors, then...
Acquired haemophilia A (AHA) is a rare haemorrhagic disease characterised by new-onset symptoms associated with dramatic decrease in factor VIII levels and an anti-factor neutralising autoantibody concentration >0.6 Bethesda units. Elderly people are often affected, whereas children rarely affected; the paediatric incidence reported literature about 0.045 case/million/year. For some time, standard of care has been that for adults, but clinicians have poor outcomes. Here, we describe largest...
Bioinformatics methods are helpful to identify new molecules for diagnostic or therapeutic applications. For example, the use of peptides capable mimicking binding sites has several benefits in replacing a protein which is difficult produce, toxic. Using less expensive. Peptides easier manipulate, and can be used as drugs. Continuous epitopes predicted by bioinformatics tools commonly these sequential further experiments. Numerous discontinuous epitope predictors have been developed but only...